Abstract. The dynamics of innovative development greatly depend on the efficiency of the processes employed in creating and organizing active small innovative businesses. In this area, universities, with their innovative infrastructure and collaborative arrangements with businesses that provide a synergistic effect, play an important role. The goal is to substantiate the recommendations for commercializing the results of intellectual activities using networking mechanisms of interaction between universities and high-tech enterprises. The methods employed include process modeling and ABC-analysis, as well as a systematic approach to the networking of universities and enterprises producing high-tech products. The model for the processes of commercializing innovations with the participation of universities was based on the business design methodology. The article contains an analysis of the development state of small innovative enterprises, as well as prospects for the development of interactive network mechanisms between universities and high-tech enterprises. The article defines the special role played by universities in the process of commercializing innovations; proposes models of classification, and reveals the methods of approach to an organizational and economic model of collaboration between universities and enterprises producing high-tech products. The results of the study are intended for use by heads of universities, small enterprises in the field of innovation, as well as hightech enterprises.