Quantitative Abnormalities of Peripheral Blood Distinct T, B, and Natural Killer Cell Subsets and Clinical Findings in Obstetric Antiphospholipid Syndrome

Carbone, J.; Gallego, A.; Lanio, N.; Navarro, J.; Orera, María; Aguarón, Ángel; Fernández‐Cruz, Eduardo; Sarmiento, E.

doi:10.3899/jrheum.081079

Cited by 30 publications

(38 citation statements)

References 33 publications

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“…We previously described increased levels of activated T-cell subsets in women with obstetric APS [13]. We also reported that higher levels of activated T-cells were associated with thrombosis in patients with HIV disease [15].…”

Section: Discussionmentioning

confidence: 99%

“…This substudy was not included in routine analyses. We previously investigated the association between levels of CD4 and CD8 subsets and obstetric APS [13], unexplained recurrent miscarriage [14], and chronic infectious diseases in patients who develop thrombosis [15]. In addition to the exclusion criteria set out above, the patients were not immunized and did not have active infections during the 6 months before the immunological study.…”

Section: Methodsmentioning

confidence: 99%

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CD8+DR+ T-Cells and C3 Complement Serum Concentration as Potential Biomarkers in Thrombotic Antiphospholipid Syndrome

Sarmiento

Dale

Arraya

et al. 2014

Autoimmune Diseases

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Purpose. To assess complement factors and T lymphocyte activation subset abnormalities in patients with thrombotic antiphospholipid syndrome (APS) as potential biomarkers for development of clinical complications. Methods. We assessed C3, C4, factor B concentrations (nephelometry), complement haemolytic functional activity (CH100, radial immune diffusion), and the activation status of CD4+ and CD8+ T-cells (three-colour flow cytometry) in patients with thrombotic APS. Antiphospholipid (aPL) positive patients without APS-related clinical criteria, systemic lupus erythematosus (SLE) patients, and healthy individuals were evaluated as controls. A clinical followup was performed to assess the potential relationship between the immunological parameters and development of APS-related complications. Results. Lower concentrations of C3 and higher levels of CD8+DR+ cells were risk factors for development of APS-related complications during followup, including rethrombosis and neuropsychiatric symptoms. Patients with diagnosed thrombotic APS had significantly lower levels of C3, C4, and CH100 as well as higher percentages of activated CD4+DR+ and of CD8+DR+ T-cells than healthy controls but similar to that observed in autoimmune disease controls. Conclusion. Lower C3 and C4 complement levels and higher percentages of CD8+DR+ T-cells were observed in thrombotic APS patients. The potential role of these abnormalities as biomarkers of clinical outcome warrants further evaluation in a multicenter study.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

CD8+DR+ T-Cells and C3 Complement Serum Concentration as Potential Biomarkers in Thrombotic Antiphospholipid Syndrome

Sarmiento

Dale

Arraya

et al. 2014

Autoimmune Diseases

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“…In women with RPL, 37.3% had mild to moderate increase in CD56 + pNK cells and 14.7% had marked increase (>18%). 67 Furthermore, the number of pNK cells is significantly higher in patient with APA, 20,75 which is autoimmune inflammatory condition. 76 Clinically, increased numbers of pNK cells were correlated with reduced gestational age at abortion in RPL patients with anti-phospholipid antibody syndrome (APS), 77 and down-regulation of NK cells in women with RPL was associated with a favorable pregnancy outcome.…”

Section: Pro-inflammatory Cytokines Induce Coagulationmentioning

confidence: 99%

REVIEW ARTICLE: Immunological Modes of Pregnancy Loss

Kwak‐Kim

Park

Ahn

et al. 2010

American J Rep Immunol

106

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Citation Kwak‐Kim J, Park JC, Ahn HK, Kim JW, Gilman‐Sachs A. Immunological modes of pregnancy loss. Am J Reprod Immunol 2010During the implantation period, a significant portion of embryos are lost and eventually less than half of clinically established pregnancies end as full‐term pregnancies without obstetrical complications. A significant portion of these pregnancy losses is associated with immune etiologies, including autoimmune and cellular immune abnormalities. Although an autoimmune etiology such as anti‐phospholipid antibodies (APAs) has been reported to induce placental infarct and thrombosis at maternal–fetal interface, APAs induce inflammatory immune responses as well. Inflammatory immune responses, such as increased proportions of NK cells and Th1/Th2 cell ratios in peripheral blood are related to recurrent pregnancy losses and multiple implantation failures. Systemic and local inflammatory immune responses seem to be induced by activation of Toll‐like receptors with infectious agents, fetal cell debris, or gonadotropin‐releasing hormone agonist, etc. Cellular activation of T and NK cells leads to pro‐inflammatory cytokine storm and consequently, placental infarction and thrombosis. Potential application of anti‐inflammatory therapeutic agents for the prevention of pregnancy losses should be explored further.

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“…Women with AS without thrombosis had considerably higher percentages of CD4+ cells than the control ones, higher percentages of activated CD4+, T cells, and lower percentages and absolute amounts of CD4+ cells (12). Those with thrombosis had lower CD3-cells, more highly activated CD4+ T cells.…”

Section: Figure 3 Results Of Lymphocytic Subpopulations Of the Mothementioning

confidence: 83%

Lymphocytic abnormalities in a mother suggesting transient antiphospholipid antibodies during a previous unsuccesful pregnancy

Tsompos¹

2013

Medicinski casopis

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Quantitative Abnormalities of Peripheral Blood Distinct T, B, and Natural Killer Cell Subsets and Clinical Findings in Obstetric Antiphospholipid Syndrome

Abstract: In obstetric patients with APS we documented significant changes in T, B, and NK cell homeostasis. Increased levels of CD8+DR+ and CD19+CD27-IgD+ cells might identify obstetric patients with APS at risk of having thrombosis.

Cited by 30 publications

References 33 publications

CD8+DR+ T-Cells and C3 Complement Serum Concentration as Potential Biomarkers in Thrombotic Antiphospholipid Syndrome

CD8+DR+ T-Cells and C3 Complement Serum Concentration as Potential Biomarkers in Thrombotic Antiphospholipid Syndrome

REVIEW ARTICLE: Immunological Modes of Pregnancy Loss

Lymphocytic abnormalities in a mother suggesting transient antiphospholipid antibodies during a previous unsuccesful pregnancy

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