2014
DOI: 10.1155/2014/868652
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CD8+DR+ T-Cells and C3 Complement Serum Concentration as Potential Biomarkers in Thrombotic Antiphospholipid Syndrome

Abstract: Purpose. To assess complement factors and T lymphocyte activation subset abnormalities in patients with thrombotic antiphospholipid syndrome (APS) as potential biomarkers for development of clinical complications. Methods. We assessed C3, C4, factor B concentrations (nephelometry), complement haemolytic functional activity (CH100, radial immune diffusion), and the activation status of CD4+ and CD8+ T-cells (three-colour flow cytometry) in patients with thrombotic APS. Antiphospholipid (aPL) positive patients w… Show more

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Cited by 5 publications
(2 citation statements)
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“…However the presence of split products of BF, such as Bb, in early pregnancy of non-SLE patients with adverse fetal outcomes 31 is suggestive that the alternative pathway may be implicated in obstetric APS. Data from previous studies [26][27][28]30,31 indicate that evaluation of variants of BF in obstetrical APS may constitute an interesting approach; the present study, detecting an inverse relationship between BF SF phenotype and BF*F allotype and the presence antiphospholipid antibodies in SLE patients, corroborates this position.…”
Section: Discussionsupporting
confidence: 86%
See 1 more Smart Citation
“…However the presence of split products of BF, such as Bb, in early pregnancy of non-SLE patients with adverse fetal outcomes 31 is suggestive that the alternative pathway may be implicated in obstetric APS. Data from previous studies [26][27][28]30,31 indicate that evaluation of variants of BF in obstetrical APS may constitute an interesting approach; the present study, detecting an inverse relationship between BF SF phenotype and BF*F allotype and the presence antiphospholipid antibodies in SLE patients, corroborates this position.…”
Section: Discussionsupporting
confidence: 86%
“…Hypocomplementemia has been found in half of patients with primary APS, 24 and it is considered a prognostic factor for pregnancy outcome in lupus patients with obstetrical APS. 25 In humans and animal models with obstetrical APS, the lack and/or blockage of components of the complement common pathway, such as C3, 26 C5 27 and C6 28 avoid fetal wastage. Heparine is considered effective in APS treatment, not only because of its anticoagulant properties, but also because of its activity as a complement inhibitor.…”
Section: Discussionmentioning
confidence: 99%