Abstract:Tamsulosin appears to demonstrate melanin binding affinity which approaches chloroquine and exceeds doxazosin for both iridal and CRPE-derived bovine melanin.
“…Gaynes et al also speculated that the affinity of tamsulosin to melanin may result in the deposition of the drug in the pigmented tissues of the eye. 2 We propose that affinity of tamsulosin to melanin leads to sequestration in the vascular-rich choroid tissue and as stated by Sari et al, its α 1A adrenoreceptor-blocking activity may lead to increase in choroidal thickness. Gaynes et al think that this may explain the occurrence of floppy iris syndrome long after the discontinuation of tamsulosin.…”
Section: The Effect Of Systemic Tamsulosin Hydrochloride On Choroidalmentioning
confidence: 60%
“…Gaynes et al think that this may explain the occurrence of floppy iris syndrome long after the discontinuation of tamsulosin. 2 We think that this finding may also be applicable to choroidal tissue, and an increase in choroidal thickness may not reverse to normal levels after discontinuation of tamsulosin for a period. This effect should be kept in mind when evaluating the choroidal thickness in patients with a history of tamsulosin treatment.…”
Section: The Effect Of Systemic Tamsulosin Hydrochloride On Choroidalmentioning
confidence: 83%
“…In a study, Gaynes et al investigated in vitro α 1 adrenergic receptor binding capacity of tamsulosin to the biologic melanin. 2 Their results showed that tamsulosin has a high binding affinity to the iris and choroid/retinal pigment epithelial-derived melanin. Gaynes et al also speculated that the affinity of tamsulosin to melanin may result in the deposition of the drug in the pigmented tissues of the eye.…”
Section: The Effect Of Systemic Tamsulosin Hydrochloride On Choroidalmentioning
“…Gaynes et al also speculated that the affinity of tamsulosin to melanin may result in the deposition of the drug in the pigmented tissues of the eye. 2 We propose that affinity of tamsulosin to melanin leads to sequestration in the vascular-rich choroid tissue and as stated by Sari et al, its α 1A adrenoreceptor-blocking activity may lead to increase in choroidal thickness. Gaynes et al think that this may explain the occurrence of floppy iris syndrome long after the discontinuation of tamsulosin.…”
Section: The Effect Of Systemic Tamsulosin Hydrochloride On Choroidalmentioning
confidence: 60%
“…Gaynes et al think that this may explain the occurrence of floppy iris syndrome long after the discontinuation of tamsulosin. 2 We think that this finding may also be applicable to choroidal tissue, and an increase in choroidal thickness may not reverse to normal levels after discontinuation of tamsulosin for a period. This effect should be kept in mind when evaluating the choroidal thickness in patients with a history of tamsulosin treatment.…”
Section: The Effect Of Systemic Tamsulosin Hydrochloride On Choroidalmentioning
confidence: 83%
“…In a study, Gaynes et al investigated in vitro α 1 adrenergic receptor binding capacity of tamsulosin to the biologic melanin. 2 Their results showed that tamsulosin has a high binding affinity to the iris and choroid/retinal pigment epithelial-derived melanin. Gaynes et al also speculated that the affinity of tamsulosin to melanin may result in the deposition of the drug in the pigmented tissues of the eye.…”
Section: The Effect Of Systemic Tamsulosin Hydrochloride On Choroidalmentioning
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