Quantifying the risk of coronary artery disease in a community: The Bambuí Project

Barreto, Sandhi Maria; Passos, Valéria Maria Azeredo; Cardoso, Alisson Renê Aquino; Lima‐Costa, Maria Fernanda

doi:10.1590/s0066-782x2003001400002

Cited by 26 publications

(21 citation statements)

References 18 publications

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“…These findings agree with those observed among all residents over 60 in Bambuí, a community in Minas Gerais State (28). Another epidemiological investigation conducted in the Northeast and Southeast regions of Brazil also showed a higher prevalence of obesity and hypertension among women over 50 years (29).…”

Section: Discussionsupporting

confidence: 88%

Frequency of Werner helicase 1367 polymorphism and age-related morbidity in an elderly Brazilian population

Smith

Silva

Araújo

et al. 2005

Braz J Med Biol Res

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Werner syndrome (WS) is a premature aging disease caused by a mutation in the WRN gene. The gene was identified in 1996 and its product acts as a DNA helicase and exonuclease. Some specific WRN polymorphic variants were associated with increased risk for cardiovascular diseases. The identification of genetic polymorphisms as risk factors for complex diseases affecting older people can improve their prevention, diagnosis and prognosis. We investigated WRN codon 1367 polymorphism in 383 residents in a district of the city of São Paulo, who were enrolled in an Elderly Brazilian Longitudinal Study. Their mean age was 79.70 ± 5.32 years, ranging from 67 to 97. This population was composed of 262 females (68.4%) and 121 males (31.6%) of European (89.2%), Japanese (3.3%), Middle Eastern (1.81%), and mixed and/or other origins (5.7%). There are no studies concerning this polymorphism in Brazilian population. These subjects were evaluated clinically every two years. The major health problems and morbidities affecting this cohort were cardiovascular diseases (21.7%), hypertension (83.7%), diabetes (63.3%), obesity (41.23%), dementia (8.0%), depression (20.0%), and neoplasia (10.8%). Their prevalence is similar to some urban elderly Brazilian samples. DNA was isolated from blood cells, amplified by PCR and digested with PmaCI. Allele frequencies were 0.788 for the cysteine and 0.211 for the arginine. Genotype distributions were within that expected for the Hardy-Weinberg equilibrium. Female gender was associated with hypertension and obesity. Logistic regression analysis did not detect significant association between the polymorphism and morbidity. These findings confirm those from Europeans and differ from Japanese population.

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Section: Discussionsupporting

confidence: 88%

Frequency of Werner helicase 1367 polymorphism and age-related morbidity in an elderly Brazilian population

Smith

Silva

Araújo

et al. 2005

Braz J Med Biol Res

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“…Em Salvador (Bahia), cidade com elevada frequência de baixa escolaridade e renda, foi crítico o perfil de risco cardiovascular da população adulta 15 . Em Bambuí (Minas Gerais), foi encontrada associação entre escolaridade menor que 4 anos e maior risco para doenças cardiovasculares em adultos 16 . A presença simultânea de dois ou mais fatores de risco para doenças cerebrovasculares também foi verificada em pessoas com menor escolaridade 15,16 e da raça negra 15 .…”

Section: Discussionunclassified

Mortalidade por doenças cerebrovasculares por residência e local de ocorrência do óbito: Paraná, Brasil, 2007

2011

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“…Almost half of the population between 60 and 75 years old will have a 20% chance of developing coronary heart disease over the next ten years, on the basis of the Framingham Heart Study scoring for predicting heart disease. 5 Another important matter is the increase risk of end-stage renal failure, considering the levels of serum creatinine directly associated with age. 6 The reasons for the excessive hospitalization among the elderly were determined in the Bambuí Health and Aging Study.…”

Section: Brazil Is Getting Older: Some Lessons From the Bambuí Healthmentioning

confidence: 99%

Brazil is getting older: some lessons from the Bambuí Health and Aging Study

Lotufo¹

2004

Sao Paulo Med. J.

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Quantifying the risk of coronary artery disease in a community: The Bambuí Project

Abstract: Based on these results, in the community studied, the risk of coronary artery disease may be reduced up to 44% in men and 38% in women.

Cited by 26 publications

References 18 publications

Frequency of Werner helicase 1367 polymorphism and age-related morbidity in an elderly Brazilian population

Frequency of Werner helicase 1367 polymorphism and age-related morbidity in an elderly Brazilian population

Mortalidade por doenças cerebrovasculares por residência e local de ocorrência do óbito: Paraná, Brasil, 2007

Brazil is getting older: some lessons from the Bambuí Health and Aging Study

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