Quantifying the effect of coccidiosis on broiler performance and infection outcomes in the presence and absence of control methods

Taylor, James; Walk, C. L.; Misiura, M.; Sorbara, J. O. B.; Giannenas, Ιlias; Kyriazakis, Ι.

doi:10.1016/j.psj.2022.101746

Cited by 22 publications

(11 citation statements)

References 53 publications

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“…However, the BW of broilers can be influenced by several other factors ( Baracho et al, 2019 ) and the number of birds in our study was not sufficient to evaluate performance. Moreover, the inoculation dose, type of strain and the duration of the study has an impact on the performance of the broilers as well ( Taylor et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Iohexol is an intestinal permeability marker in broilers under coccidiosis challenge

Rysman¹,

Eeckhaut²,

Croubels³

et al. 2023

Poultry Science

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Section: Discussionmentioning

confidence: 99%

Iohexol is an intestinal permeability marker in broilers under coccidiosis challenge

Rysman¹,

Eeckhaut²,

Croubels³

et al. 2023

Poultry Science

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“…All seven Eimeria species evolving in the chick's digestive tract in a specific site can induce a wide range of symptoms from mild subclinical enteric infection to subacute high mortality. The clinical conclusion of coccidial infection can be affected by Eimeria species, strains, stress, environmental factors, host genetics, simultaneous infections, infective dose and flock size (Nahed et al., 2022 ; Taylor et al., 2022 ). It is believed that weight gain is the more sensitive variable to coccidiosis and anti‐coccidial treatments (Gerhold et al., 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of therapeutic effects of an herbal mixture (Echinacea purpurea and Glycyrrhiza glabra) for treatment of clinical coccidiosis in broilers

Ghafouri

Ghaniei

Tamannaei

et al. 2022

Veterinary Medicine & Sci

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Background Avian coccidiosis is thought to be one of the most expensive infectious diseases in the poultry industry. Objectives Safe and alternative anti‐coccidial drugs are herbal extracts because they do not result in tissue residue and drug resistance. The objective of the present study was to evaluate the anti‐coccidial effect of the herbal mixture, a complex of two plants (Echinacea purpurea, Glycyrrhiza glabra) in broiler chickens in comparison with toltrazuril. Methods One hundred twenty broiler chickens were used in this experiment and divided into 4 equally numbered groups. All the groups, except Group D, were experimentally infected with mixed Eimeria spp. (E. Tenella, E. maxima, E. necatrix and E. brunetti) on day 14. Group A treated with an herbal mixture [Glycyrrhiza glabra Extract 5% (standardised to 5.4% glycyrrhizic acid) and Echinacea purpurea Extract 2% (standardised to 4% total phenolic content based on chlorogenic acid); Coxinin‐EC®; Shamim Teb Sepid Giti]. Group B treated with toltrazuril. Group C was experimentally infected with mixed Eimeria spp. but they did not have any treatment, this group was our positive control. Performance indices, faecal oocyst excretion, and intestinal lesion score were determined during the experiment. Results Positive control group had the poorest results and more mortality than other groups. Group D was not infected and was healthy all the experiment period. Treatment with herbal complex significantly reduced the negative performance and pathogenic effects associated with Eimeria spp. at a level that was comparable with toltrazuril. Conclusions In summary, the anti‐coccidial activity of the studied herbal complex suggests its use as an alternative anti‐coccidial agent to chemotherapeutic drugs for controlling coccidiosis in poultry. Highlights ‐Coccidiosis is an important infectious disease that causes serious financial loss to the poultry industry. ‐Chemical anti‐coccidial drugs and vaccines are the main control strategies to combat the disease. However, these tools have some constraints. ‐Herbal remedies are suitable alternatives to chemical compounds for control of losses associated with coccidiosis in poultry. ‐An herbal mixture (Echinacea purpurea, Glycyrrhiza glabra) has promising effects for controlling of coccidiosis in broiler chickens.

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“…Chicken coccidiosis, an intestinal disease caused by Eimeria parasites, seriously compromises the feed utilization and growth of chickens and is responsible for major economic losses of the poultry industry (Blake et al., 2020 ; Blake & Tomley, 2014 ; Shirley et al., 2005 ). Up to now, anti‐coccidial drugs and live or attenuated parasite vaccines are available to control the occurrence and outbreaks of coccidiosis (Taylor et al., 2022 ). However, alternative strategies for disease control have attracted widespread attention due to the emergence of drug resistance, tighter regulations on antibiotic use in poultry and concerns about the pathogenicity of live or attenuated vaccines (Soutter et al., 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Recombinant production of SAG1 fused with xylanase in Pichia pastoris induced higher protective immunity against Eimeria tenella infection in chicken

Liu,

Wei,

Liang

et al. 2024

Microbial Biotechnology

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Chicken coccidiosis is an intestinal disease caused by the parasite Eimeria, which severely damages the growth of chickens and causes significant economic losses in the poultry industry. Improvement of the immune protective effect of antigens to develop high efficiency subunit vaccines is one of the hotspots in coccidiosis research. Sporozoite‐specific surface antigen 1 (SAG1) of Eimeria tenella (E. tenella) is a well‐known protective antigen and is one of the main target antigens for the development of subunit, DNA and vector vaccines. However, the production and immunoprotective effects of SAG1 need to be further improved. Here, we report that both SAG1 from E. tenella and its fusion protein with the xylanase XynCDBFV‐SAG1 are recombinant expressed and produced in Pichia pastoris (P. pastoris). The substantial expression quantity of fusion protein XynCDBFV‐SAG1 is achieved through fermentation in a 15‐L bioreactor, reaching up to about 2 g/L. Moreover, chickens immunized with the fusion protein induced higher protective immunity as evidenced by a significant reduction in the shedding of oocysts after E. tenella challenge infection compared with immunized with recombinant SAG1. Our results indicate that the xylanase enhances the immunogenicity of subunit antigens and has the potential for developing novel molecular adjuvants. The high expression level of fusion protein XynCDBFV‐SAG1 in P. pastoris holds promise for the development of effective recombinant anti‐coccidial subunit vaccine.

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Quantifying the effect of coccidiosis on broiler performance and infection outcomes in the presence and absence of control methods

Cited by 22 publications

References 53 publications

Iohexol is an intestinal permeability marker in broilers under coccidiosis challenge

Iohexol is an intestinal permeability marker in broilers under coccidiosis challenge

Evaluation of therapeutic effects of an herbal mixture (Echinacea purpurea and Glycyrrhiza glabra) for treatment of clinical coccidiosis in broilers

Recombinant production of SAG1 fused with xylanase in Pichia pastoris induced higher protective immunity against Eimeria tenella infection in chicken

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