Frederik Johannes Verweij, Maarten P. Bebelman, Connie R. Jimenez, Juan J. Garcia-Vallejo, Hans Janssen, Jacques Neefjes, Jaco C. Knol, Richard de Goeij-de Haas, Sander R. Piersma, S. Rubina Baglio, Matthijs Verhage, Jaap M. Middeldorp, Anoek Zomer, Jacco van Rheenen et al.
Abstract:All mammalian cells release small endosome-derived exosomes that function in intercellular communication, but the secretion process is poorly understood. Verweij et al. developed a live-imaging approach and demonstrate that external cues can trigger exosome release from a subpopulation of multivesicular bodies by phosphorylating the target membrane SNARE SNAP23 at serine residue 110.
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