RAB27B‐activated secretion of stem‐like tumor exosomes delivers the biomarker microRNA‐146a‐5p, which promotes tumorigenesis and associates with an immunosuppressive tumor microenvironment in colorectal cancer

Cheng, Wei‐Chung; Liao, Tsai Tsen; Lin, Chun Chi; Yuan, Lan; Lan, Hsin Yi; Lin, Hung Hsin; Teng, Hao Wei; Chang, Hsin Chuan; Lin, Chi; Yang, Chung‐May; Huang, Shih Ching; Jiang, Jeng Kai; Yang, Shung Haur; Yang, Muh Hwa; Hwang, Wei Lun

doi:10.1002/ijc.32338

Cited by 92 publications

(85 citation statements)

References 63 publications

(71 reference statements)

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“…Recently, colorectal cancer stem cells have been shown to secrete EVs by a ␤-catenin/Tcf-4-activated RAB27B-dependent mechanism, exhibiting a switch of exosome RNAs from retrotransposons to microRNAs (miRNAs) (31). In particular, miR-146a may promote stem-like properties and tumorigenesis in colon cancer cells by targeting Numb.…”

Section: Cancer Stem Cell-derived Extracellular Vesiclesmentioning

confidence: 99%

Role of extracellular vesicles in stem cell biology

Bruno

Chiabotto

Favaro

et al. 2019

American Journal of Physiology-Cell Physiology

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The extracellular vesicles (EVs) are membrane vesicles carrying proteins, nucleic acids, and bioactive lipids of the cell of origin. These vesicles released within the extracellular space and entering into the circulation may transfer their cargo to neighboring or distant cells and induce phenotypical and functional changes that may be relevant in several physiopathological conditions. In an attempt to define the biological properties of EVs, several investigations have focused on their cargo and on the effects elicited in recipient cells. EVs have been involved in modulation of tumor microenvironment and behavior, as well as in the immune and inflammatory response. In the present review, we address the paracrine action of EVs released by stem cells and their potential involvement in the activation of regenerative programs in injured cells.

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Section: Cancer Stem Cell-derived Extracellular Vesiclesmentioning

confidence: 99%

Role of extracellular vesicles in stem cell biology

Bruno

Chiabotto

Favaro

et al. 2019

American Journal of Physiology-Cell Physiology

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“…Among the biologically active substances, tumor-derived exosomal miRNAs can induce TME heterogeneity while changes in TME promote tumor progression. This paradigm, similar to a positive feedback loop, makes the uncontrollable growth of the tumor [38][39][40][41][42][43]. In this article we updated the interaction of exosomal miRNAs and TME.…”

Section: Introductionmentioning

confidence: 99%

Exosomal miRNAs in tumor microenvironment

Tan

Xia

et al. 2020

J Exp Clin Cancer Res

118

102

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Tumor microenvironment (TME) is the internal environment in which tumor cells survive, consisting of tumor cells, fibroblasts, endothelial cells, and immune cells, as well as non-cellular components, such as exosomes and cytokines. Exosomes are tiny extracellular vesicles (40-160nm) containing active substances, such as proteins, lipids and nucleic acids. Exosomes carry biologically active miRNAs to shuttle between tumor cells and TME, thereby affecting tumor development. Tumor-derived exosomal miRNAs induce matrix reprogramming in TME, creating a microenvironment that is conducive to tumor growth, metastasis, immune escape and chemotherapy resistance. In this review, we updated the role of exosomal miRNAs in the process of TME reshaping.

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“…Furthermore, Cheng et al [95] studied sphere-derived colorectal cancer stem cells (CRCSC) from HCT15, HT29, and murine CT26 cells. miR-146a was found to be overly expressed in these cell lines.…”

Section: Prognostic Biomarkersmentioning

confidence: 99%

Exosomal Non Coding RNA in LIQUID Biopsies as a Promising Biomarker for Colorectal Cancer

Baassiri

Nassar

Mukherji

et al. 2020

IJMS

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Colorectal cancer (CRC) is one of the most common cancers worldwide, with a high mortality rate, especially in those that are diagnosed in late stages of the disease. The current screening blood-based markers, such as carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9), have low sensitivity and specificity. Meanwhile, other modalities are either expensive or invasive. Therefore, recent research has shifted towards a minimally invasive test, namely, liquid biopsy. Exosomes are favorable molecules sought in blood samples, since they are abundant, stable in circulation, and harbor genetic information and other biomolecules that could serve as biomarkers or even therapeutic targets. Furthermore, exosomal noncoding RNAs, such as miRNAs, lncRNAs, and circRNAs, have demonstrated the diagnostic potential to detect CRC at an early stage with a higher sensitivity and specificity than CEA and CA19-9 alone. Moreover, they have prognostic potential that is TNM stage specific and could serve as predictive biomarkers for the most common chemotherapeutic drug and combination regimen in CRC, which are 5-FU and FOLFOX, respectively. Therefore, in this review, we focus on the role of these exosomal noncoding RNAs as diagnostic, prognostic, and predictive biomarkers. In addition, we discuss the advantages and challenges of exosomes as a liquid biopsy target.

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RAB27B‐activated secretion of stem‐like tumor exosomes delivers the biomarker microRNA‐146a‐5p, which promotes tumorigenesis and associates with an immunosuppressive tumor microenvironment in colorectal cancer

Cited by 92 publications

References 63 publications

Role of extracellular vesicles in stem cell biology

Role of extracellular vesicles in stem cell biology

Exosomal miRNAs in tumor microenvironment

Exosomal Non Coding RNA in LIQUID Biopsies as a Promising Biomarker for Colorectal Cancer

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