Quantifying established clinical assessment measures using 3D-movement analysis in individuals with Down syndrome

Galli, Manuela; Cimolin, Verônica; Patti, Paul J.; Ferrario, D.; Heaney, G.; Albertini, G.; Freedland, Robert L.

doi:10.3109/09638281003734367

Cited by 19 publications

(18 citation statements)

References 17 publications

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“…The instability in trunk control may be linked to atypical finger grasping patterns (Jover et al, 2010). In a quantitative movement protocol measuring functional mobility, individuals with DS appeared to show longer durations of execution across all of the standardized tasks (Galli et al, 2010). As a consequence of hypotonia, individuals with DS have inherent joint laxity resulting in reduced gait stability and increased energetic costs for physical exertion (Agiovlasitis et al, 2009).…”

Section: Hypotoniamentioning

confidence: 99%

Neurological phenotypes for Down syndrome across the life span

Lott

2012

Progress in Brain Research

198

158

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This chapter reviews the neurological phenotype of Down syndrome (DS) in early development, childhood, and aging. Neuroanatomic abnormalities in DS are manifested as aberrations in gross brain structure as well as characteristic microdysgenetic changes. As the result of these morphological abnormalities, brain circuitry is impaired. While an intellectual disability is ubiquitous in DS, there is a wide range of variation in cognitive performance and a growing understanding between aberrant brain circuitry and the cognitive phenotype. Hypotonia is most marked at birth, affecting gait and ligamentous laxity. Seizures are bimodal in presentation with infantile spasms common in infancy and generalized seizures associated with cognitive decline observed in later years. While all individuals have the characteristic neuropathology of Alzheimer's disease (AD) by age 40years, the prevalence of dementia is not universal. The tendency to develop AD is related, in part, to several genes on chromosome 21 that are overexpressed in DS. Intraneuronal accumulation of β-amyloid appears to trigger a cascade of neurodegeneration resulting in the neuropathological and clinical manifestations of dementia. Functional brain imaging has elucidated the temporal sequence of amyloid deposition and glucose metabolic rate in the development of dementia in DS. Mitochondrial abnormalities contribute to oxidative stress which is part of AD pathogenesis in DS as well as AD in the general population. A variety of medical comorbidities threaten cognitive performance including sleep apnea, abnormalities in thyroid metabolism, and behavioral disturbances. Mouse models for DS are providing a platform for the formulation of clinical trials with intervention targeted to synaptic plasticity, brain biochemistry, and morphological brain alterations.

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Section: Hypotoniamentioning

confidence: 99%

Neurological phenotypes for Down syndrome across the life span

Lott

2012

Progress in Brain Research

198

158

View full text Add to dashboard Cite

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“…In addition, seven extra markers were positioned on landmarks of the upper body: one on each elbow (on olecranon), one on each wrist (on ulnar styloid) and three on the subject's head (bilaterally on the temporal lobes and above the nose) (after Galli et al . ).…”

Section: Methodsmentioning

confidence: 97%

“…For upper limbs and head movements, similar angle computations were made, following published protocols (Galli et al . ). The limb rotation algorithm was based on the determination of Euler angles with a Y‐X‐Z axis rotation sequence, according to Davis et al .…”

Section: Methodsmentioning

confidence: 97%

Quantitative 3D evaluation of step ascent and descent in individuals with Down syndrome – analysis of a daily challenging task

Galli

Cimolin

Ferrario

et al. 2012

J intellect Disabil Res

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“…Let us consider a pair of 3 3 ] T resolving in the body frame B and in the reference frame G, respectively, which are related by the quaternion rotation q as…”

Section: A Quaternion Rotation Operator and Representationmentioning

confidence: 99%

Quaternion-Based Kalman Filter With Vector Selection for Accurate Orientation Tracking

Zhang

Meng

2012

IEEE Trans. Instrum. Meas.

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Human body orientation estimation from microinertial/magnetic sensor units is highly important for synthetic environments, robotics, and other human-computer interaction applications. In practice, the main challenge is how to deal with linear acceleration interference and magnetic disturbance which always cause significant attitude-estimation errors. In this paper, we present a novel quaternion-based Kalman filter with vector selection scheme for accurate human body orientation estimation using an inertial/magnetic sensor unit. In the proposed algorithm, the gyroscope measurement is used as an input to construct the linear process equation, and the accelerometer and magnetometer measurements are manipulated to establish the linear pseudomeasurement equation. A linear Kalman filter is then deployed to estimate the body orientation. In the Kalman filter framework, a vector selection scheme is designed to protect the algorithm against undesirable conditions such as temporary intensive movement and magnetic disturbance and enable it to acquire more accurate orientation estimation. The experimental results have shown that the proposed algorithm can provide accurate attitude estimations with regard to the ground truth.

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Quantifying established clinical assessment measures using 3D-movement analysis in individuals with Down syndrome

Abstract: The combined quantitative/qualitative protocol is an important advancement in evaluating individuals with DS and should be integrated into a more comprehensive evaluation of dynamic gait and lower limb analysis.

Cited by 19 publications

References 17 publications

Neurological phenotypes for Down syndrome across the life span

Neurological phenotypes for Down syndrome across the life span

Quantitative 3D evaluation of step ascent and descent in individuals with Down syndrome – analysis of a daily challenging task

Quaternion-Based Kalman Filter With Vector Selection for Accurate Orientation Tracking

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