Quantitative 3<scp>D</scp> evaluation of step ascent and descent in individuals with <scp>D</scp>own syndrome – analysis of a daily challenging task

Galli, Manuela; Cimolin, Verônica; Ferrario, D.; Patti, Paul J.; Heaney, G.; Freedland, Robert L.; Albertini, G.; Brown, W. Ted

doi:10.1111/j.1365-2788.2012.01627.x

Cited by 8 publications

(11 citation statements)

References 40 publications

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“…The gait and movements of persons with TRS21 are characterized by impaired motor efficiency or clumsiness (Galli et al 2013 ;Jover et al 2010 ;Palisano et al 2001 ;Rigoldi et al 2009 ;Vicari 2006 ), and to such an extent that it has been included in the Jackson signs for the TRS21 phenotype. More interestingly, motor exercise interacts with cognitive function in Ts65Dn mice (Kida et al 2013 ).…”

Section: Heterogeneity Of Cognitive and Motor Abilities And Of Brain mentioning

confidence: 99%

Differential Brain, Cognitive and Motor Profiles Associated with Partial Trisomy. Modeling Down Syndrome in Mice

et al. 2017

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Section: Heterogeneity Of Cognitive and Motor Abilities And Of Brain mentioning

confidence: 99%

Differential Brain, Cognitive and Motor Profiles Associated with Partial Trisomy. Modeling Down Syndrome in Mice

et al. 2017

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“…10 in Lemieux et al 2016b). Consequently, DSCAM overexpression in DS may produce the opposite effect, reducing the number of spinal commissural interneurons and/or their synaptic connections, thus leading to the poor limb coordination reported in mouse models of DS (Roubertoux et al 2017;Uyanik et al 2003) as well as in patients with DS (Galli et al 2013;Galli et al 2014;Jover et al 2010;Palisano et al 2001). In this context, studying the repertoire of gaits of mouse models of DS could help to better understand the role of DSCAM in this disease.…”

Section: Dscam Overexpression In Down Syndrome: Motor Defectsmentioning

confidence: 99%

Age- and speed-dependent modulation of gaits in DSCAM^2Jmutant mice

Thiry

Lemieux

Bretzner

2018

Journal of Neurophysiology

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Gaits depend on the interplay between distributed spinal neural networks, termed central pattern generators, generating rhythmic and coordinated movements, primary afferents, and descending supraspinal inputs. Recent studies demonstrated that the mouse displays a rich repertoire of gaits. Changes in gaits occur in mutant mice lacking particular neurons or molecular signaling pathways implicated in the normal establishment of these neural networks. Given the role of the Down syndrome cell adherence molecule (DSCAM) to the formation and maintenance of spinal interneuronal circuits and sensorimotor integration, we have investigated its functional contribution to gaits over a wide range of locomotor speeds using freely walking mice. We show in this study that the DSCAM mutation, while not precluding any gait, impairs the age- and speed-dependent modulation of gaits. It impairs the ability of mice to maintain their locomotion at high treadmill speeds. DSCAM mutation induces the dominance of lateral walk over trot and the emergence of aberrant gaits for mice, such as pace and diagonal walk. Gaits were also more labile in DSCAM mutant mice, i.e., less stable, less attractive, and less predictable than in their wild-type littermates. Our results suggest that the DSCAM mutation affects the behavioral repertoire of gaits in an age- and speed-dependent manner. NEW & NOTEWORTHY Gaits evolve throughout development, up to adulthood, and according to the genetic background. Using mutant mice lacking DSCAM (a cell adherence molecule associated with Down syndrome), we show that the DSCAM mutation alters the repertoire of gaits according to the mouse's age and speed, and prevents fast gaits. Such an incapacity suggests a reorganization of spinal, propriospinal, and supraspinal neuronal circuits underlying locomotor control in DSCAM mutant mice.

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“…Step ascent and descent is one of the most common daily tasks. Although it is generally considered a rather simple movement, it may not be so easy for participants characterised by functional limitations and motor disabilities, for example, Down syndrome (DS) (Galli et al 2013;Liang et al 2018). Clinical evidence and literature studies show that the execution of this gesture is particularly difficult also in individuals with cognitive disorders.…”

Section: Introductionmentioning

confidence: 99%

“…Regarding the motion analysis, reference is made to events reported in literature studies on step ascent and descent (Riener et al 2002;Galli et al 2013). The test involves the participant standing and, at the start signal, climbing up the step (moving his preferred limb first) and stopping once both feet are resting on the step.…”

Section: Introductionmentioning

confidence: 99%

Anticipatory postural adjustments and kinematic analysis of step ascent and descent in adults with Down syndrome

Ferrario

Claes

Tarabini

et al. 2023

J intellect Disabil Res

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Background Step ascent and descent is one of the most common daily tasks. Although it is generally considered a rather simple movement, it may not be so easy for participants with Down syndrome. Methods A kinematic analysis of step ascent and descent was conducted, and a comparison between 11 adult participants with Down syndrome and 23 healthy participants was carried out. This analysis was accompanied by a posturographic analysis with the aim of evaluating aspects relating to balance. The principal aim of postural control was to investigate the trajectory of the centre of pressure, while the kinematic analysis of movement included the following: (1) the analysis of anticipatory postural adjustments, (2) the calculation of spatiotemporal parameters and (3) the evaluation of articular range of motion. Results A general instability for participants with Down syndrome, highlighted in the postural control by an increased anteroposterior and mediolateral excursion, when the test was conducted with both open and closed eyes, was found out. Regarding anticipatory postural adjustments, this deficit in balance control was revealed by the execution of small steps before completing the movement and by a much longer preparation time anticipating the movement. In addition, the kinematic analysis reported a longer ascent and descent time and a lower velocity, accompanied by a greater rising of both limbs in ascent, which indicates an increased perception of the obstacle. Finally, a wider trunk range of motion in both the sagittal and frontal planes was revealed. Conclusions All the data confirm a compromised balance control that could be associated with damage to the sensorimotor centre.

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Quantitative 3D evaluation of step ascent and descent in individuals with Down syndrome – analysis of a daily challenging task

Abstract: These findings help to elucidate the complex biomechanical strategy of people with DS during a step ascent and descent movement task and may have a major role in the multidimensional evaluation and tailored management for them.

Cited by 8 publications

References 40 publications

Differential Brain, Cognitive and Motor Profiles Associated with Partial Trisomy. Modeling Down Syndrome in Mice

Differential Brain, Cognitive and Motor Profiles Associated with Partial Trisomy. Modeling Down Syndrome in Mice

Age- and speed-dependent modulation of gaits in DSCAM^2Jmutant mice

Anticipatory postural adjustments and kinematic analysis of step ascent and descent in adults with Down syndrome

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Quantitative 3D evaluation of step ascent and descent in individuals with Down syndrome – analysis of a daily challenging task

Abstract: These findings help to elucidate the complex biomechanical strategy of people with DS during a step ascent and descent movement task and may have a major role in the multidimensional evaluation and tailored management for them.

Cited by 8 publications

References 40 publications

Differential Brain, Cognitive and Motor Profiles Associated with Partial Trisomy. Modeling Down Syndrome in Mice

Differential Brain, Cognitive and Motor Profiles Associated with Partial Trisomy. Modeling Down Syndrome in Mice

Age- and speed-dependent modulation of gaits in DSCAM2Jmutant mice

Anticipatory postural adjustments and kinematic analysis of step ascent and descent in adults with Down syndrome

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Product

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Age- and speed-dependent modulation of gaits in DSCAM^2Jmutant mice