Quantifying Effects of Pharmacological Blockers of Cardiac Autonomous Control Using Variability Parameters

Miyabara, Renata; Berg, Karsten; Kraemer, Jan F.; Baltatu, Ovidiu Constantin; Wessel, Niels; Campos, Luciana Aparecida

doi:10.3389/fphys.2017.00010

Cited by 15 publications

(29 citation statements)

References 38 publications

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“…Heart rate variability (HRV) analysis with search for new algorithms is commonly employed to measure alterations in autonomic tone with predictive value in diseases ( Campos et al, 2013 ). We have identified the CV of the heart rate as a sensitive measure of autonomic dysfunction ( Miyabara et al, 2017 ) and independently associated with vascular atherosclerosis ( Pereira et al, 2017 ). In this study, we found that CV of intrapartum cardiotocography FHR is an independent predictor of neonatal acidemia and Apgar scores.…”

Section: Discussionmentioning

confidence: 99%

Intrapartum Fetal Heart Rate: A Possible Predictor of Neonatal Acidemia and APGAR Score

et al. 2018

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Background: Predicting perinatal outcomes based on patterns of fetal heart rate (FHR) remains a challenge. The aim of this study was to evaluate intrapartum FHR variability as predictor for neonatal acidemia and APGAR score.Methods: This was a retrospective observational study of 552 childbirths. Multivariable linear regression models were used to assess the association between FHR variability and each of the following outcomes: arterial cord blood pH and base deficit, Apgar 1, and 5 scores. Variables used for adjustment were maternal age, comorbidities (gestational diabetes, preeclampsia, maternal fever, and hypertension), parity, gravidity, uterine contractions, and newborn gestational age, and weight at birth.Results: The following factors were associated with an increased risk of metabolic acidosis and low Apgar scores at birth: increased mean and coefficient of variation (CV) of the FHR, type of delivery and decreased parity. Each 10-beat/min increase in the FHR was associated with an increase of 0.43 mEq/L in the base deficit, and a decrease of 0.01 in the pH, 0.2 in the Apgar 1, and 0.14 in the Apgar 5 scores. Each 10% increase in the CV of the FHR was associated with an increase of 4.05 mEq/L in the base deficit and a decrease of 0.13 in the pH, 1.31 in the Apgar 1, and 0.86 in the Apgar 5 scores.Conclusion: These data suggest the intrapartum FHR variability is physiologically relevant and can be used for predicting the acidemia and Apgar scores at birth of the newborn infants without severe cases of morbidity and from uncomplicated pregnancies.

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Section: Discussionmentioning

confidence: 99%

Intrapartum Fetal Heart Rate: A Possible Predictor of Neonatal Acidemia and APGAR Score

et al. 2018

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“…PUFAs occur esterified or as free fatty acids cleaved from the plasma membrane by phospholipases (PL: A 1, A 2, C, and D). Once released, PUFAs can be further metabolized [8], act as second messengers [9], interact with membrane proteins [10], and/or alter the mechanical properties of the bilayer [11-15]. Yet distinguishing between some of these modalities has been quite challenging.…”

Section: Introductionmentioning

confidence: 99%

“…Importantly, recent structure-function studies have demonstrated that lipids could also contribute to channel gating via direct lipid-protein interaction. As the direct effect of PUFAs on voltage-gated Na + , K + , and Ca 2+ channels has been reviewed elsewhere [10], we will focus on other cation channels (Table 1) that do not necessarily share a common topology or PUFA-binding signature sequence, such as: glutamate receptors (N-methyl-D-aspartate receptor, NMDA), transient receptor potential (TRP) channels, mechanotransduction channel complexes, pentameric ligand-gated ion channels (pLGICs), and Ca 2+ -activated large-conductance K + (BK) channels.…”

Section: Introductionmentioning

confidence: 99%

How lipids contribute to ion channel function, a fat perspective on direct and indirect interactions

Cordero-Morales

Vásquez

2018

Current Opinion in Structural Biology

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Membrane lipid composition and remodeling influence the function of ion channels. Polyunsaturated fatty acids (PUFAs) and their derivatives modulate ion channel function; whether this effect occurs directly by binding to the protein or indirectly through alteration of membranes' mechanical properties has been difficult to distinguish. There are a large number of studies addressing the effect of fatty acids; recent structural and functional analyses have identified binding sites and provided further evidence for the role of the plasma membrane in ion channel function. Here, we review cation channels that do not share a common topology or lipid-binding signature sequence, but for which there are recent compelling data that support both direct and indirect modulation by PUFAs or their derivatives.

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“…Finally, when comparing concentric and eccentric contractions, it is worth noting that the overwhelming majority of research is carried out on lower limb tendons (patellar and Achilles). This apparent bias may be due to their specific role within energy retention and power amplification during movement [ 31 , 32 ]. Thus, both the patellar and Achilles tendon have high functional significance and, hence, high research interest.…”

Section: Are Eccentric Contractions More Effective Than Concentricmentioning

confidence: 99%

Tendon Adaptations to Eccentric Exercise and the Implications for Older Adults

Quinlan

Narici

Reeves

et al. 2019

JFMK

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The purpose of this short review is to discuss the effects of eccentric exercise in modifying the properties of tendon tissue in healthy individuals. The tendon provides a mechanical link between muscle and bone, allowing force transmission to the skeleton, and thus, its properties have significant functional implications. Chronic resistance training has long been shown to increase the stiffness and Young’s modulus of the tendon and even tendon cross-sectional area. However, as the tendon responds to the amount and/or frequency of strain, it has been previously suggested that eccentric training may result in greater adaptations due to the potential for greater training loads. Thus, this review discusses the effects of eccentric training upon healthy tendon tissue and compares these to other training modalities. Furthermore, it has been reported that the tendon may undergo adverse age-related changes. Thus, this review also discusses the potential application of eccentric resistance training as a preferential modality for counteracting these age-related changes. We conclude that while there may be no difference between contraction types for overall tendon adaptation, the lower demands of eccentric contractions may make it more appealing for the elderly population.

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Quantifying Effects of Pharmacological Blockers of Cardiac Autonomous Control Using Variability Parameters

Cited by 15 publications

References 38 publications

Intrapartum Fetal Heart Rate: A Possible Predictor of Neonatal Acidemia and APGAR Score

Intrapartum Fetal Heart Rate: A Possible Predictor of Neonatal Acidemia and APGAR Score

How lipids contribute to ion channel function, a fat perspective on direct and indirect interactions

Tendon Adaptations to Eccentric Exercise and the Implications for Older Adults

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