Quantification of veterinary antibiotics (sulfonamides and trimethoprim) in animal manure by liquid chromatography–mass spectrometry

Haller, Michel; Müller, S.; McArdell, Christa S.; Alder, Alfredo C.; Suter, Marc J.‐F.

doi:10.1016/s0021-9673(02)00083-3

Cited by 341 publications

(184 citation statements)

References 16 publications

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“…Antibiotics are designed to be easily excreted by the acceptors after administration (Halling-Sørensen et al 2002;Thiele-Bruhn et al 2004), which results in high antibiotic residues in animal manure. Some reported antibiotic concentrations in manures reach the level of microgram per kilogram (Haller et al 2002;Hamscher et al 2002;Martínez-Carballo et al 2007;Zhao et al 2010). Thus, application of manures containing antibiotics is the primary route for antibiotics to enter into terrestrial environments (Diaz-Cruz et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Changes in functional diversity of soil microbial community with addition of antibiotics sulfamethoxazole and chlortetracycline

Liu

Ying

et al. 2011

Appl Microbiol Biotechnol

105

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Section: Introductionmentioning

confidence: 99%

Changes in functional diversity of soil microbial community with addition of antibiotics sulfamethoxazole and chlortetracycline

Liu

Ying

et al. 2011

Appl Microbiol Biotechnol

105

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“…In the manure samples (i.e., M1, M2 and M3), considerably higher TC concentrations were detected in a range of 0.58-166.7 mg kg −1 , indicating that TCs were commonly used in this feedlot for disease prevention and growth promotion. The highest TC concentrations occurred in the piglet manure (M1) while the lowest occurred in the sow manure (M2), which could be attributed to different dose levels and digestive abilities of various pig types (Haller et al, 2002;Pan et al, 2011a). The detected SA concentrations were much lower (from bLOQ to 64.5 μg kg ).…”

Section: Antibiotic Concentrations Along Manure and Wastewater Treatmmentioning

confidence: 94%

Dissemination of veterinary antibiotics and corresponding resistance genes from a concentrated swine feedlot along the waste treatment paths

Wang

Ben

Yang

et al. 2016

Environment International

108

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Swine feedlots are an important pollution source of antibiotics and antibiotic resistance genes (ARGs) to the environment. This study investigated the dissemination of two classes of commonly-used veterinary antibiotics, namely, tetracyclines (TCs) and sulfonamides (SAs), and their corresponding ARGs along the waste treatment paths from a concentrated swine feedlot located in Beijing, China. The highest total TC and total SA concentrations detected were 166.7 mg kg −1 and 64.5 μg kg −1 in swine manure as well as 388.7 and 7.56 μg L −1 in swine wastewater, respectively. Fourteen tetracycline resistance genes (TRGs) encoding ribosomal protection proteins (RPP), efflux proteins (EFP) and enzymatic inactivation proteins, three sulfonamide resistance genes (SRGs), and two integrase genes were detected along the waste treatment paths with detection frequencies of 33.3-75.0%. The relative abundances of target ARGs ranged from 2.74 × 10 -6 to 1.19. The antibiotics and ARGs generally declined along both waste treatment paths, but their degree of reduction was more significant along the manure treatment path. The RPP TRGs dominated in the upstream samples and then decreased continuously along both waste treatment paths, whilst the EFP TRGs and SRGs maintained relatively stable. Strong correlations between antibiotic concentrations and ARGs were observed among both manure and wastewater samples. In addition, seasonal temperature, and integrase genes, moisture content and nutrient level of tested samples could all impact the relative abundances of ARGs along the swine waste treatment paths. This study helps understand the evolution and spread of ARGs from swine feedlots to the environment as well as assess the environmental risk arising from swine waste treatment.

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“…The milk matrix is complex and it requires different steps during the treatment of the sample, some of which are precipitation of proteins by decreasing the pH value or adding organic solvents (methanol or acetonitrile), filtration, and centrifugation. Additionally, preconcentration of analytes may be necessary, a liquid-liquid extraction [11,12] or solid-phase extraction (SPE) [13,14] is required. SPE is the sample preparation technique most usually used for the analysis of antibiotic residues in foods; it is based on the passage of the sample through a solid extractant contained in a cartridge where the analytes are retained and subsequently eluted with a suitable solvent.…”

Section: Introductionmentioning

confidence: 99%

Dispersive solid-phase extraction based on butylamide silica for the determination of sulfamethoxazole in milk samples by capillary electrophoresis

Islas

Rodríguez

Páez-Hernández

et al. 2016

Journal of Liquid Chromatography & Related Technologies

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A new method based on the combination of dispersive solid-phase extraction and capillary electrophoresis is proposed for the determination of sulfamethoxazole in milk samples. Butylamide silica was synthesized and used as extractant. Factors involved in sample treatment method such as: butylamide silica amount, NaOH concentration in methanol, sample volume, and dispersion time were evaluated using a Taguchi parameter design. Under optimal conditions, average recoveries ranged from 73 to 85% with a limit of detection of 0.05 mg L À 1 were achieved. The proposed method is a useful technique for cleanup milk samples. GRAPHICAL ABSTRACT

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Quantification of veterinary antibiotics (sulfonamides and trimethoprim) in animal manure by liquid chromatography–mass spectrometry

Cited by 341 publications

References 16 publications

Changes in functional diversity of soil microbial community with addition of antibiotics sulfamethoxazole and chlortetracycline

Changes in functional diversity of soil microbial community with addition of antibiotics sulfamethoxazole and chlortetracycline

Dissemination of veterinary antibiotics and corresponding resistance genes from a concentrated swine feedlot along the waste treatment paths

Dispersive solid-phase extraction based on butylamide silica for the determination of sulfamethoxazole in milk samples by capillary electrophoresis

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