Quantification of urinary mutagens in nurses during potential antineoplastic agent exposure

Policies and Practices Used for the Safe Handling of Antineoplastic Drugs

“…The lack of consistent use of self protective measures by personnel is troubling in light of the seemingly abundant literature on the dangers of cytotoxic drugs. While there are no specific data on the exact health risks workers face when exposed to these drugs in the workplace, there is mounting evidence that exposure does result at times in measurable, definitive consequences (Anderson, 1982;Caudell, 1988;Falck, 1979;Harrison, 1981;Hirst, 1984;Rogers, 1986;Sorsa, 1985;Stolar, 1984;Venitt, 1984;Waksvik, 1981).…”

Adverse Reproductive Outcomes and Occupational Exposures among Nurses

“…The study of chemotherapeutic agents and adverse pregnancy outcomes is somewhat more advanced than studies of other occupational hazards. Although studies of chemotherapeutic agents have produced conflicting results, adequate evidence from three epidemiologic studies (Hemrninki, 1985;Rogers, 1987;Selevan, 1985) and nine in vitro studies (Barale, 1985;Benhamou, 1986;Bos, 1982;Caudell, 1988;Chrysostomou, 1984;Cloak, 1985;Norppa, 1980;Stucker, 1986;Waksvik, 1981) suggests an association between exposure to these agents and adverse pregnancy outcomes.…”