Quantification of tannins and related polyphenols in commercial products of tormentil (<i>Potentilla tormentilla</i>)

Fecka, Izabela; Kucharska, Alicja Z.; Kowalczyk, Adam

doi:10.1002/pca.2570

Cited by 25 publications

(17 citation statements)

References 39 publications

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“…Among the flavan-3-ols, we identified six compounds: (+)-catechin ( 6 ) and five oligomeric procyanidins type B—two PC dimers ( 2 , 11 ), two PC trimers ( 5 , 20 ), and a PC tetramer ( 22 ), which had characteristic pseudomolecular (compound 6 ), or fragment (compounds 2 , 5 , 11 , 20 , 22 ) ions at m / z 289.0723 and others [ 32 ]. Oszmiański et al [ 3 ], in addition to these compounds, also identified (–)-epicatechin.…”

Section: Resultsmentioning

confidence: 99%

Iridoids, Phenolic Compounds and Antioxidant Activity of Edible Honeysuckle Berries (Lonicera caerulea var. kamtschatica Sevast.)

et al. 2017

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Iridoid and polyphenol profiles of 30 different honeysuckle berry cultivars and genotypes were studied. Compounds were identified by ultra-performance liquid chromatography coupled with electrospray ionization mass spectrometry (UPLC-ESI-qTOF-MS/MS) in positive and negative ion modes and quantified by HPLC-PDA. The 50 identified compounds included 15 iridoids, 6 anthocyanins, 9 flavonols, 2 flavanonols (dihydroflavonols), 5 flavones, 6 flavan-3-ols, and 7 phenolic acids. 8-epi-Loganic acid, pentosyl-loganic acid, taxifolin 7-O-dihexoside, and taxifolin 7-O-hexoside were identified in honeysuckle berries for the first time. Iridoids and anthocyanins were the major groups of bioactive compounds of honeysuckle constituents. The total content of quantified iridoids and anthocyanins was between 128.42 mg/100 g fresh weight (fw) (‘Dlinnoplodnaya’) and 372 mg/100 g fw (‘Kuvshinovidnaya’) and between 150.04 mg/100 g fw (‘Karina’) and 653.95 mg/100 g fw (‘Amur’), respectively. Among iridoids, loganic acid was the dominant compound, and it represented between 22% and 73% of the total amount of quantified iridoids in honeysuckle berry. A very strong correlation was observed between the antioxidant potential and the quantity of anthocyanins. High content of iridoids in honeysuckle berries can complement antioxidant properties of phenolic compounds.

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Section: Resultsmentioning

confidence: 99%

Iridoids, Phenolic Compounds and Antioxidant Activity of Edible Honeysuckle Berries (Lonicera caerulea var. kamtschatica Sevast.)

et al. 2017

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“…The minor phytoconstituents of the analyzed extract were glycoside derivatives of ellagic acid. Fecka et al (2015) reported that the main components of the tormentil tinctures were oligomeric tannins with an average content of 5.26 mg/g, procyanidin C2 (3.36 mg/g) and agrimoniin (2.05 mg/g). Table 1 contains detailed UV-VIS and MS data for all the detected compounds together with their preliminary or full identification.…”

Section: Resultsmentioning

confidence: 99%

Antithrombotic Potential of Tormentil Extract in Animal Models

et al. 2017

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Potentilla species that have been investigated so far display pharmacological activity mainly due to the presence of polyphenols. Recently, it was shown that polyphenol-rich extract from rhizome of Potentilla erecta (tormentil extract) affects the metabolism of arachidonic acid and exerts both anti-inflammatory and anti-oxidant activities, suggesting a possible effect on thrombosis. Accordingly, the aim of the study was to evaluate the effect of tormentil extract on haemostasis in a rat model of thrombosis. Lyophilized water-methanol extract from P. erecta rhizome was administrated per os for 14 days in doses of 100, 200, and 400 mg/kg in a volume of 2 mL/kg in a 5% water solution of gummi arabici (VEH). In the in vivo experiment an electrically induced carotid artery thrombosis model with blood flow monitoring was used in Wistar rats. Collected blood samples were analyzed ex vivo functionally and biochemically for changes in haemostasis. Tormentil extract (400 mg/kg) significantly decreased thrombus weight and prolonged the time to carotid artery occlusion and bleeding time without changes in the blood pressure. In the ex vivo experiment tormentil extract (400 mg/kg) reduced thromboxane production and decreased t-PA activity, while total t-PA concentration, as well as total PAI-1 concentration and PAI-1 activity remained unchanged. Furthermore, tormentil extract (400 mg/kg) decreased bradykinin concentration and shortened the time to reach maximal optical density during fibrin generation. Prothrombin time, activated partial thromboplastin time, QUICK index, fibrinogen level, and collagen-induced aggregation remained unchanged. To investigate the involvement of platelets in the antithrombotic effect of tormentil, the extract was administrated per os for 2 days to mice and irreversible platelets activation after ferric chloride induced thrombosis was evaluated under intravital conditions using confocal microscopy system. In this model tormentil extract (400 mg/kg) significantly reduced platelet activation at the same extent as acetylsalicylic acid. Taken together, we have shown for the first time that tormentil extract inhibits arterial thrombosis in platelet- and endothelial-dependent mechanisms without hemodynamic changes. Further studies on the detailed mechanism of action of tormentil extract toward fibrinolysis and the kinin system should be carried out.

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“…The extraction procedures applied for agrimoniin determination in plants and commercial products (Table ) are generally solid–liquid extraction (SLE) using acetone, 70% acetone solution, 60% acetone solution, 50% aqueous methanol solution, pure methanol, pure water, or hot water . It has been reported that ellagitannins may be unstable if treated with higher temperatures, resulting in their decomposition to ellagic acid .…”

Section: Analytical Approaches For Agrimoniin Determinationmentioning

confidence: 99%

A comprehensive review of agrimoniin

Grochowski

Skalicka-Woźniak

Orhan

et al. 2017

Annals of the New York Academy of Sciences

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Plant tannins are a unique class of polyphenols with relatively high molecular weights. Within the ellagitannins group, agrimoniin--dimeric ellagitannin--is one of the most representative compounds found in many plant materials belonging to the Rosaceae family. Agrimoniin was first isolated in 1982 from roots of Agrimonia pilosa Ledeb. (Rosaceae), a plant traditionally used in Japan and China as an antidiarrheal, hemostatic, and antiparasitic agent. Agrimoniin is a constituent of medicinal plants, which are often applied orally in the form of infusions, decoctions, or tinctures. It is also present in commonly consumed food products, such as strawberries and raspberries. It is metabolized by human gut microbiota into a series of low-molecular-weight urolithins with proven anti-inflammatory and anticancer in vivo and in vitro bioactivities. The compound has received widespread interest owing to some interesting biological effects and therapeutic activities, which we elaborate in the present review. Additionally, we present an overview of the techniques used for the analysis, isolation, and separation of agrimoniin from the practical perspective.

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Quantification of tannins and related polyphenols in commercial products of tormentil (Potentilla tormentilla)

Cited by 25 publications

References 39 publications

Iridoids, Phenolic Compounds and Antioxidant Activity of Edible Honeysuckle Berries (Lonicera caerulea var. kamtschatica Sevast.)

Iridoids, Phenolic Compounds and Antioxidant Activity of Edible Honeysuckle Berries (Lonicera caerulea var. kamtschatica Sevast.)

Antithrombotic Potential of Tormentil Extract in Animal Models

A comprehensive review of agrimoniin

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