A comprehensive review of agrimoniin

Abstract

Plant tannins are a unique class of polyphenols with relatively high molecular weights. Within the ellagitannins group, agrimoniin--dimeric ellagitannin--is one of the most representative compounds found in many plant materials belonging to the Rosaceae family. Agrimoniin was first isolated in 1982 from roots of Agrimonia pilosa Ledeb. (Rosaceae), a plant traditionally used in Japan and China as an antidiarrheal, hemostatic, and antiparasitic agent. Agrimoniin is a constituent of medicinal plants, which are often applied orally in the form of infusions, decoctions, or tinctures. It is also present in commonly consumed food products, such as strawberries and raspberries. It is metabolized by human gut microbiota into a series of low-molecular-weight urolithins with proven anti-inflammatory and anticancer in vivo and in vitro bioactivities. The compound has received widespread interest owing to some interesting biological effects and therapeutic activities, which we elaborate in the present review. Additionally, we present an overview of the techniques used for the analysis, isolation, and separation of agrimoniin from the practical perspective.

Agrimonia procera exerts antimicrobial effects, modulates the expression of defensins and cytokines in colonocytes and increases the immune response in lipopolysaccharide-challenged piglets

“…In contrast, AP had a positive effect on nitrogen retention and food conversion ratio [ 18 ]. Antioxidant effects were also found in other studies [ 67 ]. The inconsistent results could be explained by variation in the composition of phytobiotics.…”

Phenolome of Asian Agrimony Tea (Agrimonia asiatica Juz., Rosaceae): LC-MS Profile, α-Glucosidase Inhibitory Potential and Stability

“…Gallotannins are turned into to ellagitannins through oxidative binding of the galloyl groups. Several ellagitannin derivatives form dimers after intermolecular binding with other hydrolyzable tannin molecules [ 78 ]. The content of galloylglucoses ( 2 , 3 , 5 ) was higher in May samples than in the samples collected in July during the mass flowering period.…”

Tormentillae rhizoma – Review for an Underestimated European Herbal Drug

“…Agrimoniin (C 82 H 54 O 52 ) is a dimeric ellagitannin with a molecular weight of 1871.282, having 2D-glucopyranose cores with α-glucosidic linkages in both units. The absolute configuration of all 4 atropoisomeric biaryl hexahydroxydiphenoyl (HHDP) groups is S-configuration [15]. Yields of about 2 % (w/w) can be found in the underground parts of P. erecta [16].…”

“…Local effects seem to be directly connected with its tannin-character. Much evidence is provided that the systemic effects are based on the microbiotic metabolites, the urolithins, as they are found in micromolar concentrations in body fluids and tissues after ingestion of products containing ellagitannin [15]. Urolithin A significantly enhances the gut barrier function and inhibits unwarranted inflammation via the activation of aryl hydrocarbon receptor-nuclear factor erythroid 2-related factor 2 (Nrf2)-dependent pathways that upregulate epithelial tight junction proteins.…”