Quantification of Serum 25-Hydroxyvitamin D<sub>2</sub>and 25-Hydroxyvitamin D<sub>3</sub>Using High-Performance Liquid Chromatography, Tandem Mass Spectrometry (LC-MS/MS): Correlation with PTH and Other Assay Methods.

Salameh, WA; Holmquist, BX; Lee, G; Caston-Balderama, A; Huang, Xin; Clarke, NJ; K, Zhang; Reitz, E.; Holick, M. F.

doi:10.1210/endo-meetings.2010.part1.p4.p1-181

Cited by 4 publications

(3 citation statements)

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“…In a report of 33,055 women and 77,118 men available in an abstract form, it was observed that sex and age influenced the level at which 25OHD caused the PTH levels to plateau. In men aged 21–30 years, PTH levels plateaued when 25OHD was 35–39 ng/mL whereas in females of the same age range, the plateau was reached when 25(OH)D was 30–34 ng/mL This difference was more dramatic in men aged 41–50 years in whom the PTH levels plateaued when the 25(OH)D reached 30–34 ng/mL whereas in females of the same age range, the PTH levels plateaued at 20–24 ng/mL [65,66]. Our analysis did not statistically examine the maximal suppression of PTH by 25OHD levels, although we observed a strong negative correlation between changes in PTH levels with increasing 25OHD concentrations.…”

Section: Discussionmentioning

confidence: 99%

Serum Parathyroid Hormone Responses to Vitamin D Supplementation in Overweight/Obese Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

et al. 2017

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Obesity is often associated with vitamin D deficiency and secondary hyperparathyroidism. Vitamin D supplementation typically leads to the reductions in serum parathyroid hormone (PTH) levels, as shown in normal weight individuals. Meanwhile, the dose of vitamin D supplementation for the suppression of PTH may differ in overweight and obese adults. We conducted a systematic review and meta-analysis of randomized controlled trials to determine the dose of vitamin D supplementation required to suppress PTH levels in overweight/obese individuals. We identified 18 studies that examined overweight or obese healthy adults who were supplemented with varying doses of vitamin D3. The primary outcomes examined were changes in PTH and serum 25-hydroxyvitamin D (25OHD) levels from baseline to post-treatment. The results of the meta-analysis showed that there was a significant treatment effect of vitamin D supplementation on PTH, total standardized mean difference (SMD) (random effects) = −0.38 (95% CI = −0.56 to −0.20), t = −4.08, p < 0.001. A significant treatment effect of vitamin D supplementation was also found on 25OHD, total SMD (random effects) = 2.27 (95% CI = 1.48 to 3.06) t = 5.62, p < 0.001. Data from available clinical trials that supplemented adults with D3 ranging from 400 IU to 5714 IU, showed that 1000 IU of vitamin D supplementation best suppressed serum PTH levels, total SMD = −0.58, while vitamin D supplementation with 4000 IU showed the greatest increase in serum 25OH levels. Vitamin D and calcium supplementation of 700 IU and 500 mg, respectively, also showed a significant treatment effect on the suppression of PTH with a total SMD = −5.30 (95% CI = −9.72 to −0.88). In conclusion, the meta analysis of available clinical trials indicates that 1000 IU vitamin D supplementation can suppress serum PTH levels, while 4000 IU of vitamin D was associated with the largest increase in serum 25OHD levels in the overweight and obese population.

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Section: Discussionmentioning

confidence: 99%

Serum Parathyroid Hormone Responses to Vitamin D Supplementation in Overweight/Obese Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

et al. 2017

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“…2). Salameh et al [17 ] reported on the relationship between PTH and 25(OH)D in 33 055 women and 77 118 men as related to age and sex. It is known that PTH levels can vary significantly by time of day, kidney function, age, sex, and dietary calcium and phosphorus.…”

Section: Evidence For Subclinical Deficiency Of Vitamin D: Skeletal Dmentioning

confidence: 99%

Vitamin D supplementation

Pramyothin

Holick

2012

Current Opinion in Gastroenterology

130

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“…However, from the point of view of a clinician working on a possible case of NcPHPT, a more relevant target level for 25(OH)D would be that at which the influence on PTH levels is minimized. In this regard, the results of a study by Salameh et al 90 (quoted by Holick 91 ), summarized in Table 2, can provide useful practical guidance regarding a target level of 25(OH)D.…”

Section: Normocalcemic Phptmentioning

confidence: 99%

Primary hyperparathyroidism: Disease of diverse genetic, symptomatic, and biochemical phenotypes

et al. 2021

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Genetic, symptomatic, and biochemical heterogeneity of patients with primary hyperparathyroidism (PHPT) has become apparent in recent years. An indepth, evidence-based review of the phenotypes of PHPT was conducted. This review was intended to provide the resulting information to surgeons who operate on patients with hyperparathyroidism. This review revealed that the once relatively clear distinction between familial and sporadic PHPT has This article was written by members and invitees of the International Head and Neck Scientific Group (www.IHNSG.com).

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Quantification of Serum 25-Hydroxyvitamin D₂and 25-Hydroxyvitamin D₃Using High-Performance Liquid Chromatography, Tandem Mass Spectrometry (LC-MS/MS): Correlation with PTH and Other Assay Methods.

Cited by 4 publications

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Serum Parathyroid Hormone Responses to Vitamin D Supplementation in Overweight/Obese Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Serum Parathyroid Hormone Responses to Vitamin D Supplementation in Overweight/Obese Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Vitamin D supplementation

Primary hyperparathyroidism: Disease of diverse genetic, symptomatic, and biochemical phenotypes

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Quantification of Serum 25-Hydroxyvitamin D2and 25-Hydroxyvitamin D3Using High-Performance Liquid Chromatography, Tandem Mass Spectrometry (LC-MS/MS): Correlation with PTH and Other Assay Methods.

Cited by 4 publications

References 0 publications

Serum Parathyroid Hormone Responses to Vitamin D Supplementation in Overweight/Obese Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Serum Parathyroid Hormone Responses to Vitamin D Supplementation in Overweight/Obese Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Vitamin D supplementation

Primary hyperparathyroidism: Disease of diverse genetic, symptomatic, and biochemical phenotypes

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Product

Resources

About

Quantification of Serum 25-Hydroxyvitamin D₂and 25-Hydroxyvitamin D₃Using High-Performance Liquid Chromatography, Tandem Mass Spectrometry (LC-MS/MS): Correlation with PTH and Other Assay Methods.