Quantification of Retinoid Compounds by Supercritical Fluid Chromatography Coupled to Ultraviolet Diode Array Detection

Méjean, Marie; Vollmer, Martin; Brunelle, Alain; Touboul, David

doi:10.1007/s10337-013-2508-5

Cited by 26 publications

(11 citation statements)

References 31 publications

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“…In such manner, they concluded on the adequacy of the SFC for the quality control of marketed drugs. Méjean et al also reported the validation of the quantification of retinoid compounds [114]. However in this case, the reproducibility was considered to be satisfying by the authors, in spite of quite high RSD values.…”

Section: Validated Sfc Methodsmentioning

confidence: 96%

Overview of the Analytical Lifecycle of Supercritical Fluid Chromatography Methods

Andri

Dispas

Marini

et al. 2016

AJAC

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In recent times, the overall interest over Supercritical Fluid Chromatography (SFC) is truly growing within various domains but especially for pharmaceutical analysis. However, in the best of our knowledge modern SFC is not yet applied for drug quality control in the daily routine framework. Among the numerous reported SFC methods, none of them could be found to fully satisfy to all steps of the analytical method lifecycle. Thereby, the present contribution aims to provide an overview of the current and past achievements related to SFC techniques, with a targeted attention to this lifecycle and its successive steps. The included discussions were therefore structured accordingly and emphasizing the analytical method lifecycle in accord with the International Conference on Harmonisation (ICH). Recent and important scientific outputs in the field of analytical SFC, as well as instrumental evolution, qualification strategies, method development methodologies and discussions on the topic of method validation are reviewed.

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Section: Validated Sfc Methodsmentioning

confidence: 96%

Overview of the Analytical Lifecycle of Supercritical Fluid Chromatography Methods

Andri

Dispas

Marini

et al. 2016

AJAC

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“…Acidic additives, less cited than bases, prove efficient for the analysis of acidic compounds (e.g. TFA , acetic acid, formic acid , ethanesulfonic acid , or citric acid ). While some works reported the use of both acid and base , the current trend is rather to use volatile salts.…”

Section: Chromatographic Conditions For Sfc Analysis Of Drug Moleculesmentioning

confidence: 99%

Use and practice of achiral and chiral supercritical fluid chromatography in pharmaceutical analysis and purification

Lemasson

Bertin

West

2016

J of Separation Science

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The interest of pharmaceutical companies for complementary high-performance chromatographic tools to assess a product's purity or enhance this purity is on the rise. The high-throughput capability and economic benefits of supercritical fluid chromatography, but also the "green" aspect of CO2 as the principal solvent, render supercritical fluid chromatography very attractive for a wide range of pharmaceutical applications. The recent reintroduction of new robust instruments dedicated to supercritical fluid chromatography and the progress in stationary phase technology have also greatly benefited supercritical fluid chromatography. Additionally, it was shown several times that supercritical fluid chromatography could be orthogonal to reversed-phase high-performance liquid chromatography and could efficiently compete with it. Supercritical fluid chromatography is an adequate tool for small molecules of pharmaceutical interest: synthetic intermediates, active pharmaceutical ingredients, impurities, or degradation products. In this review, we first discuss about general chromatographic conditions for supercritical fluid chromatography analysis to better suit compounds of pharmaceutical interest. We also discuss about the use of achiral and chiral supercritical fluid chromatography for analytical purposes and the recent applications in these areas. The use of preparative supercritical fluid chromatography by pharmaceutical companies is also covered.

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“…Other isoprenoids have been separated and detected using SFC-based approaches. Among the numerous examples, retinoids have been analyzed by SFC-UV for quantitative detection ( Figure 7 ) [ 61 ]. Coenzyme Q10 has been successfully resolved after supercritical extraction by SFE-SFC-MS [ 62 ].…”

Section: Applications To Lipid Analysismentioning

confidence: 99%

“…1. Retinyl acetate, 2. retinal, 3. retinyl propionate, 4. retinol, 5. retinoic acid, 6. retinylpalmitate [ 61 ], with permission.…”

Section: Applications To Lipid Analysismentioning

confidence: 99%

Lipidomics by Supercritical Fluid Chromatography

Laboureur

Ollero

Touboul

2015

IJMS

100

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This review enlightens the role of supercritical fluid chromatography (SFC) in the field of lipid analysis. SFC has been popular in the late 1980s and 1990s before almost disappearing due to the commercial success of liquid chromatography (LC). It is only 20 years later that a regain of interest appeared when new commercial instruments were introduced. As SFC is fully compatible with the injection of extracts in pure organic solvent, this technique is perfectly suitable for lipid analysis and can be coupled with either highly universal (UV or evaporative light scattering) or highly specific (mass spectrometry) detection methods. A short history of the use of supercritical fluids as mobile phase for the separation oflipids will be introduced first. Then, the advantages and drawbacks of SFC are discussed for each class of lipids (fatty acyls, glycerolipids, glycerophospholipids, sphingolipids, sterols, prenols, polyketides) defined by the LIPID MAPS consortium.

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Quantification of Retinoid Compounds by Supercritical Fluid Chromatography Coupled to Ultraviolet Diode Array Detection

Abstract: International audienc

Cited by 26 publications

References 31 publications

Overview of the Analytical Lifecycle of Supercritical Fluid Chromatography Methods

Overview of the Analytical Lifecycle of Supercritical Fluid Chromatography Methods

Use and practice of achiral and chiral supercritical fluid chromatography in pharmaceutical analysis and purification

Lipidomics by Supercritical Fluid Chromatography

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