Quantification of Prostate and Seminal Vesicle Interfraction Variation During IMRT

Frank, Steven J.; Dong, Lei; Kudchadker, Rajat J.; Crevoisier, R. de; Lee, Andrew K.; Cheung, R.; Choi, Seungtaek; O’Daniel, J; Tucker, Susan L.; He, Wei; Kuban, Deborah A.

doi:10.1016/j.ijrobp.2007.10.028

Cited by 76 publications

(82 citation statements)

References 33 publications

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“…This was also seen in two previous studies, one using MV CT (tomotherapy) (20) and a second using CT on rails (21). As noted in the present study, this AP systematic shift is caused mostly by bony misalignment and not internal prostate motion.…”

Section: Comparison With Other Techniquessupporting

confidence: 90%

Analysis of Interfraction Prostate Motion Using Megavoltage Cone Beam Computed Tomography

Bylund¹,

Bayouth²,

Smith³

et al. 2008

International Journal of Radiation Oncology*Biology*Physics

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Section: Comparison With Other Techniquessupporting

confidence: 90%

Analysis of Interfraction Prostate Motion Using Megavoltage Cone Beam Computed Tomography

Bylund¹,

Bayouth²,

Smith³

et al. 2008

International Journal of Radiation Oncology*Biology*Physics

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“…Changes in bladder volume allows for an increase in interfraction motion, hence affecting CTV coverage. This is a concern, particularly when studies such as Frank et al (12) have shown that 90% of time the bladder volume is found to be smaller than the planned volume.…”

Section: Discussionmentioning

confidence: 99%

Dosimetric and volumetric changes in the rectum and bladder in patients receiving CBCT‐guided prostate IMRT: analysis based on daily CBCT dose calculation

Pearson

Gill

Campbell

et al. 2016

J Applied Clin Med Phys

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Delivered dose can be calculated by transferring the planned treatment beams onto the daily CBCT. Bladder and rectum volumetric doses were calculated and correlated to the daily bladder and rectum fullness. Patients for this study underwent hypofractionated prostate IMRT to 70 Gy in 28 fractions. Daily CBCT was utilized for image guidance. A clinically acceptable plan was created using a CTV‐to‐PTV uniform margin of 5 mm. Image fusion was performed to transfer the bladder and rectum contours onto each CBCT. Contours were then edited to match the anatomy of each CBCT. Using the daily treatment isocenter, the planned beams were transferred onto the CBCT and daily and cumulative DVHs calculated. For the results a total of 168 daily CBCTs were evaluated. The bladder was found to be smaller for 74.7% of the 168 daily CBCTs accessed in this study. This reduction in volume correlated to an increase in the cumulative bladder V70 Gy from 9.47% on the planning CT to 10.99% during treatment. V70Gy for the rectum was 7.27% on the planning CT, when all six patients were averaged, and increased to 11.56% on the average of all daily treatment CBCTs. Increases in volumetric rectum dose correlated with increases in rectal volume. For one patient, the rectum and bladder absolute V70 Gy, averaged over the course of treatment, increased by 295% and 61%, respectively. Larger variations in the daily bladder and rectal volume were observed and these correlated to large deviations from the volumetric dose received by these structures. In summary, bladder and rectum volume changes during treatment have an effect on the cumulative dose received by these organs. It was observed that the volumetric dose received by the bladder decreases as the volume of the bladder increases. The inverse was true for the rectum.PACS number(s): 87.55.dk‐, 87.57.Q‐

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“…By applying intensity-modulated RT in combination with offline or online image-guided setup correction protocols, toxicity can be reduced (2). Presently, prostate setup correction protocols focus mainly on reducing the error caused by interfraction prostate motion (3)(4)(5)(6), although more institutes these days are starting to study the effect of intrafraction prostate motion (7,8). Many different imaging techniques can be used, for example, ultrasound, portal imaging, megavolt computed tomography (CT), in-room CT, cone beam CT (CBCT), in-room magnetic resonance imaging, and four-dimensional (4D) marker-based localization systems like Calypso (1).…”

Section: Introductionmentioning

confidence: 99%

Residual Seminal Vesicle Displacement in Marker-Based Image-Guided Radiotherapy for Prostate Cancer and the Impact on Margin Design

Smitsmans

Bois

Sonke

et al. 2011

International Journal of Radiation Oncology*Biology*Physics

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Quantification of Prostate and Seminal Vesicle Interfraction Variation During IMRT

Cited by 76 publications

References 33 publications

Analysis of Interfraction Prostate Motion Using Megavoltage Cone Beam Computed Tomography

Analysis of Interfraction Prostate Motion Using Megavoltage Cone Beam Computed Tomography

Dosimetric and volumetric changes in the rectum and bladder in patients receiving CBCT‐guided prostate IMRT: analysis based on daily CBCT dose calculation

Residual Seminal Vesicle Displacement in Marker-Based Image-Guided Radiotherapy for Prostate Cancer and the Impact on Margin Design

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