Quantification of phenolic contents and antioxidant capacity of Atlantic sea cucumber, Cucumaria frondosa

Mamelona, Jean; Pelletier, Émilien; Girard-Lalancette, Karl; Legault, Jean; Karboune, Salwa; Kermasha, Sélim

doi:10.1016/j.foodchem.2007.01.016

Cited by 133 publications

(132 citation statements)

References 26 publications

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“…Estos resultados se encuentran entre los valores normales registrados para extractos de organismos marinos, los cuales varían de 2,0 a 9,7 mg EAG/g (Althunibat et al 2009, Mamelona et al 2007. En lo que respecta al extracto acuoso, se observó un valor más alto que los usualmente informados para organismos marinos.…”

Section: Resultsunclassified

Actividad antioxidante del erizo de mar Mellita quinquiesperforata (Leske) e identificación de sus compuestos lipídicos mayoritarios

2016

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Section: Resultsunclassified

Actividad antioxidante del erizo de mar Mellita quinquiesperforata (Leske) e identificación de sus compuestos lipídicos mayoritarios

2016

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“…Until now, 1,400 species of sea cucumbers have been identified and reported worldwide (10). Sea cucumbers are benthic animals with diverse and useful medicinal properties (11). Therefore, the isolation, structure elucidation, and screening of their bioactive compounds has received increasing attention.…”

Section: Introductionmentioning

confidence: 99%

Identification and Quantification of Phthalate Pollution in Holothuria atra, a Sea Cucumber from the Persian Gulf (Iran)

Sharifi

Yegdaneh

Sajjadi

et al. 2017

Jundishapur J Nat Pharm Prod

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In recent years, microplastics have accumulated in oceans and sediments worldwide. Due to their small size, microplastics may be ingested by low trophic fauna, with uncertain consequences for the health of the organism. Sea cucumbers are one of the major echinoderms from the class Holothuroidea that ingest plasticizers in their mouth and filter the water. Regarding the recent interests on probable pollution of medicinal plants and other natural medicines, like marine organisms to phthalates, in this study a phthalate ester was isolated from Holothuria atra of Persian coasts for the first time. The structure of the compound was elucidated using spectroscopic data (IR, NMR and MS) and the compound was used as a standard for quantification of microplastic in H. atra, a marker of pollutant in the Persian Gulf. Quantification was done by high performance thin layer chromatography and the amount of bis (2-ethylhexyl) phthalate (BEHP) was 0.15 ± 0.08 mg/g.

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“…This methodology can be divided in 2 steps: a first non-polar extraction with dichloromethane, in which similar compounds as lipids and non-polar metabolites are extracted; and a second hydrophilic extraction using methanol as solvent in order to obtain more polar compounds. This approximation allowed the enrichment of the extracts into highly hydroxylated metabolites, which would correspond to the phenolic compounds described by Mamelona et al (2007), who described greater yields in the presence of aqueous solvents, especially from muscle and gonads in sea cucumbers from the Atlantic Sea.…”

Section: Resultsmentioning

confidence: 99%

Characterization of bioactive molecules isolated from sea cucumber Athyonidium chilensis

Sottorff¹,

Aballay²,

Hernández³

et al. 2013

Rev. biol. mar. oceanogr.

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4Agri-Food Laboratories-Concepción, SGS Chile Ltda. Américo Vespucio 820, Parque Industrial Las Arucas, Talcahuano, ChileResumen.-En la última década se ha incrementado el interés por la búsqueda de moléculas con potencial biomédico y amigable para el ambiente. Desde esta perspectiva, la búsqueda de principios bioactivos de origen marino ha permitido valorar la diversidad biológica presente en los ecosistemas acuáticos. En el Phylum Equinodermata, se destaca la familia Holothuridae, por su capacidad de sintetizar moléculas como saponinas y otros metabolitos secundarios de alto interés farmacológico debido a su capacidad hemolítica, antitumoral, anti-inflamatoria, antimicrobiana, citostática y antineoplásica. El interés del presente trabajo se centró en la caracterización de un extracto purificado obtenido desde Athyonidium chilensis (Holothuria) mediante técnicas cromatográficas y de espectrometría de masas, con la posterior evaluación de su potencial bioactivo sobre modelos in vitro. Como resultado de estos análisis, se identificaron 2 saponinas. La primera con un peso molecular de 1522 Da y altamente conjugada con monosacáridos. La segunda con un peso molecular de 764 Da fue identificada como holoturinósido D. Respecto a los resultados de la actividad biológica del extracto purificado, éste mostró actividad antibacteriana, antifúngica y citotóxica frente a una línea celular de neuroblastoma. Los resultados de este estudio se convierten en la primera caracterización de moléculas con actividad biológica desde Athyonidium chilensis. Palabras clave: Holothuria, holoturinósido D, saponinaAbstract.-In the last decade, the interest for searching molecules with biomedical potential as well as innocuous for the environment has been increased. Under this perspective, the search for bioactive principles of marine origin has allowed to value the biological diversity present in aquatic systems. In phylum Echinodermata, the family Holothuridae is distinguished by its capacity of synthesizing molecules such as saponins and other secondary metabolites of high pharmacological interest because of their interesting haemolytic, antitumor, anti-inflammatory, antimicrobial, cytostatic and antineoplastic capacity. The aim of the present study was focused on the characterization of a purified extract obtained from Athyonidium chilensis (Holothuria) by chromatographic and mass spectrometric techniques and the later assessment of its bioactive potential on in vitro models. As a result of these analyses 2 saponins were identified. The first with a molecular weight of 1522 Da and highly conjugated with monosaccharides. The second with a molecular weight of 764 Da was identified as holothurinoside D. The biological activity of the purified extract showed antibacterial, antifungal and cytotoxic activity on a neuroblastoma cell line. Outcomes of this study correspond to the first characterization of molecules with biological activity from Athyonidium chilensis.

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Quantification of phenolic contents and antioxidant capacity of Atlantic sea cucumber, Cucumaria frondosa

Cited by 133 publications

References 26 publications

Actividad antioxidante del erizo de mar Mellita quinquiesperforata (Leske) e identificación de sus compuestos lipídicos mayoritarios

Actividad antioxidante del erizo de mar Mellita quinquiesperforata (Leske) e identificación de sus compuestos lipídicos mayoritarios

Identification and Quantification of Phthalate Pollution in Holothuria atra, a Sea Cucumber from the Persian Gulf (Iran)

Characterization of bioactive molecules isolated from sea cucumber Athyonidium chilensis

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