Quantification of ketoprofen enantiomers in human plasma based on solid-phase extraction and enantioselective column chromatography

Development and Validation of a Bioanalytical Method for Direct Extraction of Diclofenac Potassium from Spiked Plasma

“…General tests performed were: recovery, accuracy, precision, reproducibility, linearity, specificity, limit of detection and quantification and ruggedness [12][13][14].…”

Supramolecular Chiro-Biomedical Assays and Enantioselective HPLC Analyses for Evaluation of Profens as Non-Steroidal Anti-Inflammatory Drugs, Potential Anticancer Agents and Common Xenobiotics

“…Asami and Nakamura [104] also used Pirkle-type CSP as the Sumipax OA 4000 column for the chiral separation of amide derivative of ibuprofen and carbamate-alkylester derivatives of loxoprofen with n-hexane-ethanol (99:1,%,v/v) and nhexane-dichloroethane-ethanol (90:10:1,%,v/v/v) as mobile phases, respectively. Boisvert et al [105] used Chirex 3005 column for direct chiral quantification of ketoprofen with mobile phase of 0.02 M ammonium acetate in methanol. Uray et al [63] applied Whelk-O1 for the enantiomeric separation of flobufen and its metabolites.…”

Resolution of enantiomers of ketoprofen by HPLC: a review

“…In the second indirect approach, derivatization was carried out with an enantiomerically pure reagent leading to the formation of diastereomers, which then were separated either on an achiral octa decyl silica column (Foster and Jamali, 1987;Bjorkman, 1987;Palylk and Jamali, 1991;Iwakawa et al, 1991;Wright and Jamali, 1993;Pehourcq et al, 1995;Landoni and Lees, 1995;Sallusito et al, 1986;Panus et al, 1998;Lagrange et al, 2001) or by using normal silica column (Hayball et al, 1991). There have been reports where enantiomers of the underivatized ketoprofen have also been separated using the proteinbased column (Soglowek et al, 1990;Oda et al, 1991), (R)-N-(3,5-dinitrobenzoyl)-phenylglycine based silica (Yagi et al, 1990;Oi et al, 1995;Boisvert et al, 1997), cellulose-based stationary phase (Mauleon et al, 1994;Carr et al, 1995;Overbeke et al, 1995;Lovlin et al, 1996;Tang, 1996;Jamali et al, 1997;Hoke et al, 2000), chiral stationary phase (CSP) consisting of benzamido group attached to silica (Grubb et al, 1996;Al-Katheeri et al, 2000) or glycopeptide-type CSP and micra non-porus octadecyl silica column (Ameyibor and Stewart, 1998).…”