Quantification of Inter-Erythrocyte Forces with Ultra-High Frequency (410 MHz) Single Beam Acoustic Tweezer

Lim, Haegyun; Shung, K. K.

doi:10.1007/s10439-017-1863-z

Cited by 31 publications

(26 citation statements)

References 27 publications

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“…10log 10 R = −2.00 dB (4) 10log 10 T = −4.34 dB (5) RT loss = 5.33 dB. The experimental conversion loss is higher (worse) than that of theoretical prediction because the sound axis between the silica glass buffer rod and reflection plate was deviated.…”

Section: A Transducer Performance In Water Mediummentioning

confidence: 94%

“…One is to thin down single crystal plates and the other is to grow thick piezoelectric films. Lim and Shung [5] reported the 7.1-μm-thick polished LiNbO 3 single crystal focused transducer operating at 410 MHz for the evaluation of interactive forces of red blood cells. Chen et al [6] reported the mechanically polished LiNbO 3 single crystal focused transducer operating at 526 MHz for microparticle manipulation applications.…”

Section: Introductionmentioning

confidence: 99%

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ScAlN Thick-Film Ultrasonic Transducer in 40–80 MHz

Sano

Karasawa

Yanagitani

2018

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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A medical ultrasound diagnostic system and an ultrasonic microscope are generally used in the frequency range of 1-20 MHz and 100 MHz-2 GHz, respectively. Ultrasonic transducers in the frequency range of 20-100 MHz are, therefore, not well developed because of less application into ultrasonic imaging or suitable piezoelectric materials with this frequency range. Polyvinylidene difluoride (PVDF) is usually used for ultrasonic transducers in the 10-50-MHz ranges. However, their electromechanical coupling coefficient k 2 t of 4% is not enough for the practical uses. In order to excite the ultrasonic wave in the 20-100 MHz range, a 125-25-µm-thick piezoelectric film is required when the longitudinal velocity of the material is assumed to be 5000 m/s. However, it is difficult to grow such a thick piezoelectric film without a crack being caused by the internal stress during the dry deposition technique. We achieved a stress-free film growth by employing the unique hot target sputtering technique without heating the substrate. High-efficient 81-(k 2 t = 18.5%) and 43-MHz (k 2 t = 15.2%) ultrasonic generation by using the 43-and 90-µm extremely thick ScAlN (Sc: 39%) films were demonstrated, respectively. We discussed the advantage of ScAlN thick-film transducers by comparing them with the conventional PVDF transducer for the water medium.

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Section: A Transducer Performance In Water Mediummentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

ScAlN Thick-Film Ultrasonic Transducer in 40–80 MHz

Sano

Karasawa

Yanagitani

2018

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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“…The internal construction of the BTB transducer is shown in Figure 1 b. The transducers were fabricated through the following procedure for creating a high-frequency transducer [ 34 , 35 , 36 , 37 , 38 ]. The optimized aperture size and thickness of the piezoelectrical material and the matching layer thickness for the individual imaging and therapeutic transducers were simulated with the Krimholtz, Leedom, and Matthaei models (PiezoCAD, Sonic Concepts, Bothell, WA, USA).…”

Section: Methodsmentioning

confidence: 99%

Thermal Ablation and High-Resolution Imaging Using a Back-to-Back (BTB) Dual-Mode Ultrasonic Transducer: In Vivo Results

Lim

Kim

et al. 2021

Sensors

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We present a back-to-back (BTB) structured, dual-mode ultrasonic device that incorporates a single-element 5.3 MHz transducer for high-intensity focused ultrasound (HIFU) treatment and a single-element 20.0 MHz transducer for high-resolution ultrasound imaging. Ultrasound image-guided surgical systems have been developed for lesion monitoring to ensure that ultrasonic treatment is correctly administered at the right locations. In this study, we developed a dual-element transducer composed of two elements that share the same housing but work independently with a BTB structure, enabling a mode change between therapy and imaging via 180-degree mechanical rotation. The optic fibers were embedded in the HIFU focal region of ex vivo chicken breasts and the temperature change was measured. Images were obtained in vivo mice before and after treatment and compared to identify the treated region. We successfully acquired B-mode and C-scan images that display the hyperechoic region indicating coagulation necrosis in the HIFU-treated volume up to a depth of 10 mm. The compact BTB dual-mode ultrasonic transducer may be used for subcutaneous thermal ablation and monitoring, minimally invasive surgery, and other clinical applications, all with ultrasound only.

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“…Recently, acoustic tweezers have garnered increased interest from the biomedical research community, as they can perform noncontact, label-free, and precise manipulation of bioparticles (1,(8)(9)(10)(11). With these merits, acoustic tweezers have been used in a wide range of biomedical applications, including patterning and printing cells (12)(13)(14)(15), separating and sorting cells (16)(17)(18)(19), controlling cell-cell interactions (20,21), single-cell analysis (22)(23)(24), concentrating bioparticles (25)(26)(27)(28)(29)(30)(31), acousto-mechanical phenotyping (32,33), constructing tissues (34)(35)(36)(37)(38), generating and translating droplets (39)(40)(41), rotating multicellular organisms (42,43), and isolating extracellular vesicles (44,45).…”

Section: Introductionmentioning

confidence: 99%

Generating multifunctional acoustic tweezers in Petri dishes for contactless, precise manipulation of bioparticles

et al. 2020

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Acoustic tweezers are a promising technology for the biocompatible, precise manipulation of delicate bioparticles ranging from nanometer-sized exosomes to millimeter-sized zebrafish larva. However, their widespread usage is hindered by their low compatibility with the workflows in biological laboratories. Here, we present multifunctional acoustic tweezers that can manipulate bioparticles in a disposable Petri dish. Various functionalities including cell patterning, tissue engineering, concentrating particles, translating cells, stimulating cells, and cell lysis are demonstrated. Moreover, leaky surface acoustic wave–based holography is achieved by encoding required phases in electrode profiles of interdigitated transducers. This overcomes the frequency and resolution limits of previous holographic techniques to control three-dimensional acoustic beams in microscale. This study presents a favorable technique for noncontact and label-free manipulation of bioparticles in commonly used Petri dishes. It can be readily adopted by the biological and medical communities for cell studies, tissue generation, and regenerative medicine.

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Quantification of Inter-Erythrocyte Forces with Ultra-High Frequency (410 MHz) Single Beam Acoustic Tweezer

Cited by 31 publications

References 27 publications

ScAlN Thick-Film Ultrasonic Transducer in 40–80 MHz

ScAlN Thick-Film Ultrasonic Transducer in 40–80 MHz

Thermal Ablation and High-Resolution Imaging Using a Back-to-Back (BTB) Dual-Mode Ultrasonic Transducer: In Vivo Results

Generating multifunctional acoustic tweezers in Petri dishes for contactless, precise manipulation of bioparticles

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