Quantification of inhaled aerosol particles composed of toxic household disinfectant using radioanalytical method

Shim, Hyung Jin; Lee, Jae Young; Lee, Chang Heon; Mushtaq, Sajid; Song, Ha Yeon; Song, Longfei; Choi, Seong‐Jin; Lee, Kyuhong; Jeon, Jongho

doi:10.1016/j.chemosphere.2018.05.132

Cited by 33 publications

(21 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to respiratory and skin-related health effects directly related to HD exposure, there have been concerns about the possible health effects in other organs, such as liver. 41) When rats were made to inhale PHMG labeled with indium-111 ( 111 In) for 7 days, 74% of PHMG was distributed to the lungs and 5.3% to the liver after 168 hours. 41) Although it is unclear whether HD exposure affects liver health in humans, it is suggested that exposure to HD can cause toxic hepatitis.…”

Section: Association Between Inhalational Exposure To Hds and Other Hmentioning

confidence: 99%

“…41) When rats were made to inhale PHMG labeled with indium-111 ( 111 In) for 7 days, 74% of PHMG was distributed to the lungs and 5.3% to the liver after 168 hours. 41) Although it is unclear whether HD exposure affects liver health in humans, it is suggested that exposure to HD can cause toxic hepatitis. Studies on the investigation of diverse health effects, which have not been considered, in exposure to toxic chemicals in HDs are underway.…”

Section: Association Between Inhalational Exposure To Hds and Other Hmentioning

confidence: 99%

See 1 more Smart Citation

The past, present, and future of humidifier disinfectant-associated interstitial lung diseases in children

Lee

Hong

2020

Clin Exp Pediatr

View full text Add to dashboard Cite

Exposure to environmental factors can cause interstitial lung diseases (ILDs); however, such types of ILDs are rare. From 2007 to 2011, an ILD epidemic occurred in South Korea owing to inhalational exposure to toxic chemicals in humidifier disinfectants (HDs). HD-associated ILDs (HD-ILDs) are characterized by rapidly progressing respiratory failure with pulmonary fibrosis and a high mortality rate of 43.8%−58.0%. Although 18.1%−31.1% of the general population used HDs, only a small proportion of HD users were diagnosed with HD-ILDs. This finding suggests that investigation of the pathophysiologies underlying HD-ILDs is needed in addition to the identification of susceptibility to HD-ILDs. Further, there have been several concerns regarding the diverse health effects of exposure to toxic chemicals in HDs, including those that have not been identified, and long-term prognoses in terms of pulmonary function and residual pulmonary lesions observed on follow-up chest images. In this review, we summarize the clinical features, pathologic findings, and changes in radiologic findings over time in patients with HD-ILDs and the results of previous experimental research on the mechanisms underlying the effects of toxic chemicals in HDs. Studies are currently underway to identify the pathophysiologies of HD-ILDs and possible health effects of exposure to HDs along with the development of targeted therapeutic strategies. The experience of identification of HD-ILDs has encouraged stricter control of safe chemicals in everyday life.

show abstract

Section: Association Between Inhalational Exposure To Hds and Other Hmentioning

confidence: 99%

Section: Association Between Inhalational Exposure To Hds and Other Hmentioning

confidence: 99%

The past, present, and future of humidifier disinfectant-associated interstitial lung diseases in children

Lee

Hong

2020

Clin Exp Pediatr

View full text Add to dashboard Cite

show abstract

“…Considering the movement of HD in the lungs, which spreads from the lungs to the whole body [26], the toxic effects of PHMG on pulmonary epithelial cells through ROS and the NOTCH signaling pathways, and mitochondrial dysfunction have also been found in blood vessels, liver, kidneys, bone marrow, nerves, and muscles. Bone marrow damage can be associated with idiopathic pulmonary fibrosis by abnormal immune modulation of immune cells [27].…”

Section: New Hypothesis About Mitochondrial Diseasesmentioning

confidence: 99%

Mitochondria disease due to humidifier disinfectants: diagnostic criteria and its evidences

Leem

Kim

2020

Environ Anal Health Toxicol

View full text Add to dashboard Cite

Introduction: Humidifier disinfectants (HDs) study results so far achieved From 2002 through 2020, about 1,600 people were reported to die of fatal injuries associated with the use of humidifier disinfectants (HDs) in South Korea. Several chemical disinfectants used for household humidifiers were later clinically confirmed to cause HD-associated lung injury (HDLI). Polyhexamethylene guanidine phosphate (PHMG-P) is the main ingredient of the HDs associated with lung disease. Epidemiological studies, animal studies, and dose-response analysis demonstrated a strong association between HDs use and lung injuries. The diagnostic criteria for HDLI was defined on the basis of the clinical, pathological, and radiological attributes of the patients [1]. Because of the fatal lung injuries in South Korea, investigations into the adverse health effects of HDs have focused on the lung toxicity of PHMG-P [2]. Therefore, the following toxicologic studies focused on the association between HDs and pulmonary fibrosis. PHMG-P aerosol particles induce pulmonary inflammatory and fibrotic responses [3]. As PHMG-P-induced lung fibrosis is different from that induced by known fibrogenic agents, such as bleomycin, it is important to understand the molecular mechanisms underlying this effect. Guanidine-based disinfectants, PHMG-P, polyhexamethylene biguanide (PHMB), and oligo (2-(2-ethoxy) ethoxyethyl guanidinium chloride (PGH) induce epithelial-mesenchymal transition in A549 alveolar epithelial cells [4]. PHMG-P promotes reactive oxygen species (ROS) generation and consequently increases the expression of DNA damage markers, such as ATM and H2AX phosphorylation [5]. NOTCH1 transcripts significantly increased in lung tissues from HDLI cases compared to unexposed controls (p=0.05), so NOTCH1 may play an important role in the pulmonary fibrosis of HDLI [6]. PHMG-P induced epithelial-mesenchymal transition (EMT) through Akt/NOTCH signaling pathways and ZEB2 played an important role in PHMG-P-induced lung toxicity [7]. Age-period-cohort (APC) analysis using health insurance data showed that many diseases, such as asthma, bronchiec

show abstract

“…However, it is difficult to quantify its distribution in biological tissues using typical analytical instrumentation. In 2018, our research group reported using a novel radioanalytical technique to determine the biodistribution of PHMG aerosols [ 44 ]. We first labeled polymeric PHMG with 111 In.…”

Section: In Vivo Assessment Of Hazardous Substances Using Radioanamentioning

confidence: 99%

Radioanalytical Techniques to Quantitatively Assess the Biological Uptake and In Vivo Behavior of Hazardous Substances

et al. 2020

Self Cite

View full text Add to dashboard Cite

Concern about environmental exposure to hazardous substances has grown over the past several decades, because these substances have adverse effects on human health. Methods used to monitor the biological uptake of hazardous substances and their spatiotemporal behavior in vivo must be accurate and reliable. Recent advances in radiolabeling chemistry and radioanalytical methodologies have facilitated the quantitative analysis of toxic substances, and whole-body imaging can be achieved using nuclear imaging instruments. Herein, we review recent literature on the radioanalytical methods used to study the biological distribution, changes in the uptake and accumulation of hazardous substances, including industrial chemicals, nanomaterials, and microorganisms. We begin with an overview of the radioisotopes used to prepare radiotracers for in vivo experiments. We then summarize the results of molecular imaging studies involving radiolabeled toxins and their quantitative assessment. We conclude the review with perspectives on the use of radioanalytical methods for future environmental research.

show abstract

Quantification of inhaled aerosol particles composed of toxic household disinfectant using radioanalytical method

Cited by 33 publications

References 30 publications

The past, present, and future of humidifier disinfectant-associated interstitial lung diseases in children

The past, present, and future of humidifier disinfectant-associated interstitial lung diseases in children

Mitochondria disease due to humidifier disinfectants: diagnostic criteria and its evidences

Radioanalytical Techniques to Quantitatively Assess the Biological Uptake and In Vivo Behavior of Hazardous Substances

Contact Info

Product

Resources

About