Quantification of Incensole in Three Boswellia Species by NIR Spectroscopy Coupled with PLSR and Cross‐Validation by HPLC

Abstract

The findings are in total agreement with the HPLC analysis suggesting that NIR spectroscopy coupled with PLSR is a robust, rapid and non-destructive alternate method for the quantification of incensole in B. papyrifera. Copyright © 2018 John Wiley & Sons, Ltd.

Analysis of incensole acetate in Boswellia species by near infrared spectroscopy coupled with partial least squares regression and cross-validation by high-performance liquid chromatography

“…High-performance liquid chromatographic quantification and NIR spectroscopy coupled with PLS regression analysis of IA in the methanol extract of resin and stem bark of B. papyrifera, respectively, are reported. 15,16 In the continuation of previous work, 5,17,18 the quantification of IA employing NIR spectroscopy coupled with PLS regression in different fractions of B. papyrifera is reported and the results are crosschecked by HPLC analysis.…”

“…2 Pharmacological and medicinal uses of the frankincense are well documented. [3][4][5][6][7][8] A wide range of biological applications of Boswellia resins including anti-proliferative, neuroprotective, anti-plasmodial, anti-inflammatory and anti-depression [6][7][8][9] are also reported. The psychoactive nature of frankincense is likely due to the existence of incensole and incensole acetate in varying amounts depending on the species of Boswellia.…”

“…(gum-producing, multipurpose perennial tree) is native to Sudan and Ethiopia and is recognized to be of high medicinal as well as economic importance. 5 B. papyrifera resin differs from other types of frankincense due to the presence of two unusual and unique chemical markers: incensole and incensole acetate (IA, a macrocyclic cembrenoid diterpenoid). Incensole acetate, found in significant amount in B. papyrifera, has psychoactive, anxiolytic, 10 anti-inflammatory 11 and antidepressive [12][13][14] activities.…”

Triterpenic Acids as Non-Competitive α-Glucosidase Inhibitors from Boswellia elongata with Structure-Activity Relationship: In Vitro and In Silico Studies

“…Comparing boswellic acids, compound 4 (9.9 ± 0.48 μM) showed potent inhibition followed by 11 (14.9 ± 1. 14, epi-α-amyrin (15), α-amyrin (16) [43] tricosanoic acid (17) [44], incensole (18) [32,45], viridiflorol (19) [46], iso-serratol (20) [47,48] and lupenone (21) [49,50] were determined on the basis of spectroscopic techniques and by comparison with the published data (Figure 1).…”

Cembrane-type diterpenoids from the gum resin of Boswellia carterii and their biological activities

“…4. Incensole obtained as the main cembrane-type diterpenoid from the gum resin of B. carterii, 14,[18][19][20] is proposed as the precursor for the other cembranes, which gradually acetylized, oxidized, and isomerized to their derivatives. Isolated compounds (1-10) were examined for the antiproliferative activity against HCT-116 human colon cancer cell, anti-inammatory activity against nitric oxide (NO) production, and hepatoprotective activity, with cisplatin (5.6 mM), dexamethasone (2.2 mM), and bicyclol being used as the positive controls, respectively.…”