Quantification of historical exposures in occupational cohort studies

Stewart, Patricia A.; Lees, Peter S.J.; Francis, Marcie

doi:10.5271/sjweh.161

Cited by 59 publications

(34 citation statements)

References 36 publications

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“…Quantitative exposure estimation was therefore not performed and should probably not be attempted without measurement data. 12 We have previously presented a semiquantitative job exposure matrix for exposure to amorphous silica fume in these plants. 8 This matrix was not applied in this study as adjustments for other relevant exposures-for example, asbestos-could not be performed.…”

Section: Study Populationmentioning

confidence: 99%

Study of cancer incidence among 8530 male workers in eight Norwegian plants producing ferrosilicon and silicon metal.

1999

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Objectives-To examine the association between cancer incidence, in particular incidence of lung cancer, and duration of work among employees in eight Norwegian plants producing ferrosilicon and silicon metal. Results-A total of 832 cases of cancer were observed against 786 expected (standardised incidence ratio (SIR) 1.06). Among the furnace workers an increased incidence of lung cancer (SIR 1.57) and testicular cancer (SIR 2.30) was found. Internal comparisons of rates by Poisson regression analysis among the rural furnace workers showed a positive trend between incidence of lung cancer and duration of work of 1.05 (95% confidence interval (95% CI) 1.00 to 1.10)/work-year. Excess cases of prostate and kidney cancer were found among blue collar nonfurnace workers, in particular among the mechanics. Conclusion-The results suggest associations between furnace work and lung and testicular cancer, and between nonfurnace work and prostate cancer. (Occup Environ Med 1999;56:625-631)

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Section: Study Populationmentioning

confidence: 99%

Study of cancer incidence among 8530 male workers in eight Norwegian plants producing ferrosilicon and silicon metal.

1999

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“…Some researchers have developed approaches that combine some of these methods (Stewart et al, 1996), allowing for more specific questions to be targeted at subjects likely to have been exposed to the exposures of interest. A more recent approach uses expert systems, jobspecific modules, and computer-assisted personal interviews (CAPI) called OccIDEAS (Fritschi et al, 2012).…”

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confidence: 99%

Assessing Occupational Exposure to Chemicals in an International Epidemiological Study of Brain Tumours

Tongeren

Kincl

Richardson

et al. 2013

The Annals of Occupational Hygiene

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(1960-1974 and 1975-1984). Benzene exposure estimates in early periods were modified upwards. The internal consistency of hydrocarbon exposures and exposures to engine exhaust fumes was improved. Finally, exposure to polycyclic aromatic hydrocarbon and benzo(a)pyrene was modified to include the contribution from second-hand smoke. The crosswalk ensured that the FInJEM exposure estimates could be applied to the InTErOCC study subjects. The modifications generally resulted in an increased prevalence of exposure to chemical agents. This increased prevalence of exposure was not restricted to the lowest categories of cumulative exposure, but was seen across all levels for some agents. Although this work has produced a JEM with important improvements compared to FInJEM, further improvements are possible with the expansion of agents and additional external data.

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“…Several authors have shown that an assessment performed by experienced hygienists helped by local specialists is reliable, 24 25 albeit not very sensitive. 26 Some misclassification of exposure may occur due to the lack of detail in some work histories. This will tend to bias any true associations between exposure and disease risk towards the null value.…”

Section: Discussionmentioning

confidence: 99%

Cancer mortality in a synthetic spinning plant in Besançon, France

Hours¹,

Févotte

Lafont

et al. 2007

Occup Environ Med

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Objectives: To assess the mortality of a cohort of workers in a synthetic textile spinning plant and to evaluate the relationship between mortality from lung, liver and bladder cancer and the processes or the products used. Methods: The study population consisted of male workers present for at least 6 months in the plant from 1968 to 1984. The cohort was followed until 1999. Vital status and the causes of death were determined by consulting national registries. The population of the Franche-Comté region was used for comparison. In total, 17 groups of exposure were assessed by the industrial hygienist, based on the consensus of an expert group that determined the exposure levels of each job to selected occupational hazards. Each worker was assigned to one or several groups, according to his occupational history. Confounding factors could not be assessed. Standardised mortality ratios (SMR) and 95% bilateral confidence intervals were calculated based on an assumed Poisson distribution of the number of cases to compare the plant mortality and the population mortality. Internal analyses were performed with Cox models in order to assess the risks of death related to the various exposures.

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Quantification of historical exposures in occupational cohort studies

Cited by 59 publications

References 36 publications

Study of cancer incidence among 8530 male workers in eight Norwegian plants producing ferrosilicon and silicon metal.

Study of cancer incidence among 8530 male workers in eight Norwegian plants producing ferrosilicon and silicon metal.

Assessing Occupational Exposure to Chemicals in an International Epidemiological Study of Brain Tumours

Cancer mortality in a synthetic spinning plant in Besançon, France

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