Quantification of Face Brown Spots and Freckles with Image Analysis Method.

Masuda, Yuji; Takei, Kiyoko; Mizugaki, Megumi

doi:10.5107/sccj.28.147

Cited by 6 publications

(3 citation statements)

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“…Hence, clinical trials performed in human volunteers are critical to determine the efficacy profile of these topical products. The objective assessment of the extent and severity of skin pigmentation disorders benefits from a series of methods, but only a few of them are well suited for spotty changes [6,9,[14][15][16][17][18]. In this study, we used a narrow-band reflectance spectrophotometer equipped with a small-diameter probe.…”

Section: Discussionmentioning

confidence: 99%

“…In youth, the various physiological stimulations of melanogenesis increase evenly the eumelanin pigmentation or induce phaeomelanin-enriched freckles without any prominent change in the melanocyte density. By contrast, intense and chronic ultraviolet light exposures result in a mottled appearance typical of photo-ageing and PUVA-induced changes [1][2][3][4][5][6]. Indeed, the number, distribution and synthetic activity of melanocytes become uneven in such conditions, as well as the capacity to transfer melanosomes to keratino- Hermanns/Petit/Piérard-Franchimont/ Paquet/Piérard cytes.…”

Section: Introductionmentioning

confidence: 99%

“…Control of these hyperpigmentations is becoming ever more important as the aged population continues to grow. In particular, Asian-type skin is reputed to be particularly prone to such skin changes [6,7].…”

Section: Introductionmentioning

confidence: 99%

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Assessment of Topical Hypopigmenting Agents on Solar Lentigines of Asian Women

et al. 2002

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Background: So-called darkened age spots encompass distinct pathological processes. The efficacy of topical depigmenting agents is difficult to objectivate. Objective: To assess the hypopigmenting effect of three cosmetic formulations using objective biometrological methods. Methods: 50 women of South-East Asian ancestry were enrolled in this pilot study. They had solar lentigines according to dermoscopic criteria. The lesions were treated by topical hypopigmenting formulations. Products were applied twice daily for 2 or 3 months. Assessments at 1-month intervals were made using narrow-band reflectance spectrophotometry, image analysis of video-recorded ultraviolet light reflection and photodensitometry- and image-analysis-assisted corneomelametry. Results: A 20% azelaic acid formulation and another one containing 5% ascorbyl glucosamine, 1% kojic acid and α-hydroxyacid esters appeared inefficacious on solar lentigines. A stabilized soy extract showed a better although modest lightening effect when assessed by corneomelametry. The subclinical or faint mottled skin revealed by ultraviolet light examination better responded (p < 0.05) to treatments. Conclusion: Focal epidermal hyperpigmentation is better controlled by topical whitening agents when the increase in melanin content reflects a modest functional hyperactivity of melanocytes.

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