Quantification of cyclic DNA polymerization with lanthanide coordination nanomaterials for liquid biopsy

Zhou, Wenting; Wang, Lei; Liu, Can; Teng, Qiuyi; Wang, Zhaoyin; Dai, Zhihui

doi:10.1039/c9sc06408g

Cited by 27 publications

(21 citation statements)

References 41 publications

(39 reference statements)

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“…The phenomenon should be ascribed to coordination of STPP to Zr ions in clusters of PCN-224, blocking subsequent binding with the phosphate backbone of DNA. Besides, monophosphate (Pi), pyrophosphate (PPi) and hexametaphosphate (SHMP) were used to modulate the interaction, suggesting that the site-occupying effect can be induced by various phosphates, especially polyphosphates with terminal phosphates. , Because the site-occupying effect works on metal ions rather than structures or ligands of MOFs, interactions of F-ssDNA with other Zr-MOFs, including Uio-66, PCN-222, and PCN-223 can be tuned by STPP as well (Figure B). Although MOFs synthesized with other metal ions may also attract F-ssDNA depending on nonspecific adsorption, , the interactions between these MOFs and F-ssDNA are unaffected by STPP, signifying that formation of Zr–O–P bonds is the prerequisite to reveal the site-occupying effect.…”

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confidence: 99%

Construction of Molecular Sensing and Logic Systems Based on Site-Occupying Effect-Modulated MOF–DNA Interaction

Wei

et al. 2020

J. Am. Chem. Soc.

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102

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Interactions between metal−organic frameworks (MOFs) and nucleic acids are of great importance in molecular assembly. However, current MOF−nucleic acid interactions lack diversity and are normally realized in an uncontrollable manner. Herein, the interaction of zirconium-based MOFs (Zr-MOFs) with nucleic acids is enabled by the formation of Zr−O−P bonds and further manipulated by a phosphate-induced site-occupying effect. Covering Zr ions in clusters of MOFs with phosphates impedes the formation of Zr−O−P bonds with nucleic acids, rendering the MOF−nucleic acid interaction tunable and stimulus-responsive. Notably, the experimental results demonstrate that various phosphates, Zr-MOFs, and nucleic acids can all be adopted in the tunable interaction. On the basis of these findings, fluorescent DNA and typical Zr-MOFs are proposed as functional probe−quencher pairs to establish molecular sensing and logic systems. Accordingly, alkaline phosphatase and inorganic pyrophosphatase can be quantified simultaneously, and the overall relation of different phosphates and phosphatases is facilely displayed. The work provides a general strategy for modulating MOF−nucleic acid interactions, which is conducive to the development of molecular intelligent systems.

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confidence: 99%

Construction of Molecular Sensing and Logic Systems Based on Site-Occupying Effect-Modulated MOF–DNA Interaction

Wei

et al. 2020

J. Am. Chem. Soc.

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102

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“…The key step in in vitro diagnosis assays is to capture or detect these biomarkers, which is essential for the subsequent analysis of tumor diagnosis, metastasis, and prognosis (P. Ding, Wang, Wu, Zhou, et al, 2020; P. Ding, Wang, Wu, Zhu, et al, 2020; H. Liu, Sun, et al, 2020). Common detection methods include quartz crystal microbalance (QCM) (B. Li et al, 2020), electrochemiluminescence (ECL) (Babamiri, Hallaj, & Salimi, 2018; Shi, Li, & Hu, 2019), electrochemical impedance spectroscopy (EIS) (Cevik, 2019), flow cytometry (Doan et al, 2018), fluorescence (W. Zhou, Wang, et al, 2020), and others. A previous review has comprehensively covered the application of nanotechnology in CTCs detection (Myung, Park, Wang, & Hong, 2018).…”

Section: Applications Of Dendritic Nano‐scale Systems In Cancer Diagnmentioning

confidence: 99%

“…Liu, Sun, et al, 2020). Common detection methods include quartz crystal microbalance (QCM) (B. , electrochemiluminescence (ECL) (Babamiri, Hallaj, & Salimi, 2018;Shi, Li, & Hu, 2019), electrochemical impedance spectroscopy (EIS) (Cevik, 2019), flow cytometry (Doan et al, 2018), fluorescence (W. Zhou, Wang, et al, 2020), and others. A previous review has comprehensively covered the application of nanotechnology in CTCs detection (Myung, Park, Wang, & Hong, 2018).…”

Section: In Vitro Diagnosis Of Cancermentioning

confidence: 99%

Recent advances in development of dendritic polymer‐based nanomedicines for cancer diagnosis

Sun

Zhu

et al. 2020

WIREs Nanomed Nanobiotechnol

172

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Dendritic polymers have highly branched three‐dimensional architectures, the fourth type apart from linear, cross‐linked, and branched one. They possess not only a large number of terminal functional units and interior cavities, but also a low viscosity with weak or no entanglement. These features endow them with great potential in various biomedicine applications, including drug delivery, gene therapy, tissue engineering, immunoassay and bioimaging. Most review articles related to bio‐related applications of dendritic polymers focus on their drug or gene delivery, while very few of them are devoted to their function as cancer diagnosis agents, which are essential for cancer treatment. In this review, we will provide comprehensive insights into various dendritic polymer‐based cancer diagnosis agents. Their classification and preparation are presented for readers to have a precise understanding of dendritic polymers. On account of physical/chemical properties of dendritic polymers and biological properties of cancer, we will suggest a few design strategies for constructing dendritic polymer‐based diagnosis agents, such as active or passive targeting strategies, imaging reporters‐incorporating strategies, and/or internal stimuli‐responsive degradable/enhanced imaging strategies. Their recent applications in in vitro diagnosis of cancer cells or exosomes and in vivo diagnosis of primary and metastasis tumor sites with the aid of single/multiple imaging modalities will be discussed in great detail. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Diagnostic Tools > in vivo Nanodiagnostics and Imaging Diagnostic Tools > in vitro Nanoparticle‐Based Sensing

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“…Nucleotides play an essential role in the self-assembly of biocoordinated polymers and the synthesis of chiral nanomaterials. 38 Among the many nucleotides, adenosine 5′triphosphate (ATP) is one of the substances that cannot be ignored. ATP is the primary source of energy for the critical activities of cells in the body and is generally regarded as the "energy currency" of most organisms, regulating the vital activities of cells, enhancing cellular metabolism, and playing an essential role in biological activities.…”

Section: Introductionmentioning

confidence: 99%

Au–Cu Bimetallic Nanostructures for Photothermal Antibacterial and Wound Healing Promotion

Song

Liu

Zhang

et al. 2022

ACS Appl. Nano Mater.

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The spread of drug-resistant bacterial infections can lead to serious infectious diseases and pose a significant threat to public health security. Metallic-nano-antibacterial materials are gradually becoming a hot spot for antimicrobial biomaterials research with the advantages of long service life and fast effective bactericidal speed. Considering the construction of a safe and efficient photothermal therapy (PTT) antibacterial platform as a promising strategy for the treatment of bacterial infections, a near-infrared (NIR) bimetallic antibacterial nanoparticle, adenosine 5′-triphosphate (ATP)@Au-Cu nanoparticle (NP), with excellent photothermal conversion efficiency (59.3%) was prepared in this paper; ATP@Au-CuNPs with their multiarm shaped structure and NIR photothermal effect could significantly inhibit the growth of bacteria at the low concentrations. In addition, the cytotoxicity and hemolysis rate of the ATP-coated nanoparticles were reduced considerably, and they also exhibited antibacterial and wound healing-promoting effects in mice wound infection models. On this basis, this paper focuses on the preparation and properties of ATP@Au-CuNPs and explores their biological application in antibacterial therapy.

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Quantification of cyclic DNA polymerization with lanthanide coordination nanomaterials for liquid biopsy

Abstract: DNA polymerization is quantified by fluorescent pyrophosphate–cerium lanthanide coordination polymer networks, and is used to detect circulating tumor DNA sensitively.

Cited by 27 publications

References 41 publications

Construction of Molecular Sensing and Logic Systems Based on Site-Occupying Effect-Modulated MOF–DNA Interaction

Construction of Molecular Sensing and Logic Systems Based on Site-Occupying Effect-Modulated MOF–DNA Interaction

Recent advances in development of dendritic polymer‐based nanomedicines for cancer diagnosis

Au–Cu Bimetallic Nanostructures for Photothermal Antibacterial and Wound Healing Promotion

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