Quantification of Crystal Growth of Calcium Oxalate in Gel and its Modification by Urinary Constituents in a New Flow Model of Crystallization

Abstract

Drinking therapy and lowering of urinary oxalate excretion can be concluded to be the most promising means of preventing CaOx urolithiasis. The new crystallization model demonstrated here should be suitable to new applications in the investigation of urinary stone formation.

Synthesis of L‐valine crystals

“…The density of L-valine was determined as: 1.26(1) g/cm 3 and this agreed with that of the literature [14]. The lattice parameters determined from the collected X-ray data compare well with the earlier results [14] confirming the identity of L-valine crystals.…”

“…Bio-mineralization takes place in a gel-like medium and hence in-vitro crystallization of such biominerals in gel received much attention [2]. Also, this provides simulation of biological fluids [3]. Gel growth of some urinary stone constituents, viz., calcium oxalate monohydrate, calcium hydrogen phosphate and ammonium magnesium phosphate and the role played by extracts or juices of natural products in crystal growth were studied earlier [4].…”

Growth, spectral and thermal studies of ibuprofen crystals

“…Crystallization can be done by several methods; among them there are many advantages in gel growth. The structure of gel medium is similar to synovial cartilage and other biological fluids; hence crystallization of drugs particularly in gel medium may help to understand the growth and inhibition as such in a biological environment [1]. Ibuprofen, 2-(4-isobutylphenyl)-propionic acid, is a nonsteroidal anti-inflammatory drug that is widely used as an analgesic [2].…”

Crystal Growth of some Urinary Stone Constituents: I. In-Vitro Crystallization of L-Tyrosine and its Characterization

“…Crystallization of urinary stone constituents should be carried out in a gelatinous medium rather than in solutions or suspensions. Also, gel seems to be an ideal medium to study crystallization of urinary stones as its viscous nature provides simulation of synovial cartilage and other biological fluids (Archilles et al 1995).…”