Quantification of all 209 PCB congeners in blood—Can indicators be used to calculate the total PCB blood load?

Kraft, Martin; Rauchfuss, Knut; Sievering, Silvia; Wöckner, Mandy; Neugebauer, Frank; Fromme, Hermann

doi:10.1016/j.ijheh.2016.09.006

Cited by 30 publications

(24 citation statements)

References 22 publications

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“…Indeed, the people at the highest risk of adverse PCB related effects are those from high fish-consuming populations (Barone et al 2014). PCB 153 constitutes the bulk of PCB congeners found in humans—making it a vital PCB to study (Kraft et al 2017). Once in the body, PCBs accumulate in various organs leading to inflammation (Sipka et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Intestinal exposure to PCB 153 induces inflammation via the ATM/NEMO pathway

Phillips

Dheer

Santaolalla

et al. 2018

Toxicology and Applied Pharmacology

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Section: Introductionmentioning

confidence: 99%

Intestinal exposure to PCB 153 induces inflammation via the ATM/NEMO pathway

Phillips

Dheer

Santaolalla

et al. 2018

Toxicology and Applied Pharmacology

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“…The majority of the PCB load in the studied individuals was attributable to the highly chlorinated congeners (PCB 153, PCB 180, and PCB 138). Almost half of the PCB blood burden was caused by these three marker congeners (see also Kraft et al). Therefore, exposure to PCB 28 via indoor air contributes to a relatively small proportion of the total PCB load in the blood samples of our study group, but it also represents the mono‐, di‐, and trichlorinated PCBs to a large extent.…”

Section: Resultsmentioning

confidence: 99%

“…Indoor air and blood sampling occurred between November 2013 and February 2014. The sampling and analysis of all 209 PCB congeners in human blood samples (n = 35) are described in Kraft et al . PCB contamination in the indoor air was measured in 35 office rooms that were frequented by the participants.…”

Section: Methodsmentioning

confidence: 99%

“…To determine the extent that mono‐, di‐, and trichlorinated biphenyls occur in indoor air and the blood of exposed individuals, we analyzed all PCBs belonging to this spectrum (PCB 1 to PCB 39) in the indoor air of 35 office rooms with known PCB contamination, as well as in the blood of individuals working in these offices for a minimum of two years. Further information regarding the distribution of all 209 congeners in human blood can be obtained from Kraft et al …”

Section: Introductionmentioning

confidence: 99%

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Mono-, di-, and trichlorinated biphenyls (PCB 1-PCB 39) in the indoor air of office rooms and their relevance on human blood burden

Kraft

Sievering

Grün³

et al. 2018

Indoor Air

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Exposure to polychlorinated biphenyls (PCBs) from indoor air can lead to a significant increase in lower chlorinated congeners in human blood. Lower chlorinated congeners with short biological half-lives can exhibit an indirect genotoxic potential via their highly reactive metabolites. However, little is known about their occurrence in indoor air and, therefore, about the effects of possible exposure to these congeners. We analyzed all mono-, di-, and trichlorinated biphenyls in the indoor air of 35 contaminated offices, as well as in the blood of the 35 individuals worked in these offices for a minimum of 2 years. The median concentration of total PCB in the indoor air was 479 ng/m . The most prevalent PCBs in the indoor air samples were the trichlorinated congeners PCB 31, PCB 18, and PCB 28, with median levels of 39, 31, and 26 ng/m , respectively. PCB 8 was the most prevalent dichlorinated congener (median: 9.1 ng/m ). Monochlorinated biphenyls were not detected in relevant concentrations. In the blood samples, the most abundant congener was PCB 28; nearly 90% of all mono-, di-, and trichlorinated congeners were attributed to this congener (median: 12 ng/g blood lipid).

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“…The three major PCB congeners, CB-138, CB-153 and CB-180, account for approximately 50% of the total PCB concentration [17,28] and a simplified ΣPCB concentration was, therefore, calculated as the sum of congeners CB-138, CB-153 and CB-180, multiplied by 2.…”

Section: Methodsmentioning

confidence: 99%

Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury

Timmermann¹,

Choi

Petersen

et al. 2017

International Journal of Circumpolar Health

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This study was undertaken to assess the potential impact of maternal exposures to polychlorinated biphenyl (PCB), dichlorodiphenyl dichloroethylene (DDE) and methylmercury on the secondary sex ratios (the ratio of male to female live births) over a span of 23 years. The study includes prospective data from three Faroese birth cohorts, with a total of 2,152 healthy mother–child dyads recruited between 1986 and 2009. The Faroe Islands is a subarctic fishing community, where pilot whale meat and blubber are part of the traditional marine diet. Exposures were measured in maternal hair, serum or umbilical cord blood. Confounder adjusted logistic regression models were used to assess the associations between maternal exposures and the secondary sex ratio. A doubling in ΣPCB, p,p’-DDE and mercury concentrations were associated with increased odds by 8% (95% CI = 0–16%), 7% (95% CI = 0–14%) and 9% (95% CI = 2–17%), respectively, of giving birth to a boy. In conclusion, maternal exposure to ΣPCB, DDE and methylmercury was associated with a slightly increased secondary sex ratio. The impact of paternal exposures could not be taken into account and deserves attention.

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Quantification of all 209 PCB congeners in blood—Can indicators be used to calculate the total PCB blood load?

Cited by 30 publications

References 22 publications

Intestinal exposure to PCB 153 induces inflammation via the ATM/NEMO pathway

Intestinal exposure to PCB 153 induces inflammation via the ATM/NEMO pathway

Mono-, di-, and trichlorinated biphenyls (PCB 1-PCB 39) in the indoor air of office rooms and their relevance on human blood burden

Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury

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