Quantification of [11C]GB67 binding to cardiac α1-adrenoceptors with positron emission tomography: validation in pigs

Park-Holohan, So Jin; Asselin, Marie Claude; Turton, David R.; Williams, Sharron L.; Hume, Susan P.; Camici, Paolo G.; Rimoldi, Ornella

doi:10.1007/s00259-008-0805-2

Cited by 11 publications

(1 citation statement)

References 21 publications

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“…Additionally, due to the non-invasive technique of these imaging tools, their model and imaging approach can provide a means to evaluate the progression of HF and to quantify the temporal changes in flow and metabolism. In addition to the information provided on perfusion and metabolic outcomes, additional imaging could be applied to interrogate regional activation of critical receptors or enzymes within the myocardium, [24][25][26][27][28] neurohormonal changes, [29][30][31][32][33] along with regional changes in myocardial hypoxia, 34 apoptosis, 35,36 necrosis, 37 and fibrosis. 38 Unfortunately, the current study reported a high attrition (overall survival rate of 26%) with a major cause of death attributable to lethal arrhythmias during the perioperative period.…”

Section: See Related Article Pp 655-665mentioning

confidence: 99%

Creation of clinically relevant model of chronic heart failure: Application of multi-modality imaging to define physiology

Thorn

Sinusas

2015

Journal of Nuclear Cardiology

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Section: See Related Article Pp 655-665mentioning

confidence: 99%

Creation of clinically relevant model of chronic heart failure: Application of multi-modality imaging to define physiology

Thorn

Sinusas

2015

Journal of Nuclear Cardiology

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PET Imaging of Autonomic Innervation and Receptors

Thackeray

Bengel

2019

Cardiac CT, PET &Amp; MR

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Molecular Imaging of the Heart

Boutagy

Fehér

Alkhalil

et al. 2019

Comprehensive Physiology

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Multimodality cardiovascular imaging is routinely used to assess cardiac function, structure, and physiological parameters to facilitate the diagnosis, characterization, and phenotyping of numerous cardiovascular diseases (CVD), as well as allows for risk stratification and guidance in medical therapy decision‐making. Although useful, these imaging strategies are unable to assess the underlying cellular and molecular processes that modulate pathophysiological changes. Over the last decade, there have been great advancements in imaging instrumentation and technology that have been paralleled by breakthroughs in probe development and image analysis. These advancements have been merged with discoveries in cellular/molecular cardiovascular biology to burgeon the field of cardiovascular molecular imaging. Cardiovascular molecular imaging aims to noninvasively detect and characterize underlying disease processes to facilitate early diagnosis, improve prognostication, and guide targeted therapy across the continuum of CVD. The most‐widely used approaches for preclinical and clinical molecular imaging include radiotracers that allow for high‐sensitivity in vivo detection and quantification of molecular processes with single photon emission computed tomography and positron emission tomography. This review will describe multimodality molecular imaging instrumentation along with established and novel molecular imaging targets and probes. We will highlight how molecular imaging has provided valuable insights in determining the underlying fundamental biology of a wide variety of CVDs, including: myocardial infarction, cardiac arrhythmias, and nonischemic and ischemic heart failure with reduced and preserved ejection fraction. In addition, the potential of molecular imaging to assist in the characterization and risk stratification of systemic diseases, such as amyloidosis and sarcoidosis will be discussed. © 2019 American Physiological Society. Compr Physiol 9:477‐533, 2019.

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Quantification of [11C]GB67 binding to cardiac α1-adrenoceptors with positron emission tomography: validation in pigs

Abstract: The present study offers a methodology for using [(11)C]GB67 as a radioligand to quantify human myocardial alpha(1)-ARs in clinical PET studies.

Cited by 11 publications

References 21 publications

Creation of clinically relevant model of chronic heart failure: Application of multi-modality imaging to define physiology

Creation of clinically relevant model of chronic heart failure: Application of multi-modality imaging to define physiology

PET Imaging of Autonomic Innervation and Receptors

Molecular Imaging of the Heart

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