PET Imaging of Autonomic Innervation and Receptors

Thackeray, James T.; Bengel, Frank M.

doi:10.1002/9781118754467.ch6

Cited by 1 publication

(2 citation statements)

References 133 publications

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“…[ 11 C]mHED is rapidly transported into sympathetic neurons by the norepinephrine transporters by uptake-1 and stored in vesicles. It is not susceptible to monoamine oxidase (MAO) breakdown [ 14 , 15 , 16 ]. Hydroxyephedrine is synthesized by N-methylation of metaraminol which is a synthetic false neurotransmitter of norepinephrine.…”

Section: Positron Emission Tomography (Pet) Radiotracersmentioning

confidence: 99%

“…It can be synthesised from norepinephrine by direct N-methylation reporting high radiochemical purity and yield and high specific activity. Due to its more natural behaviour than [ 11 C]mHED and its susceptibility to MAO metabolism, lower overall washout rates and decreased loss of tracer due to passive diffusion have been reported [16]. 1) is a synthetic catecholamine analogue, and in contrast to mHED is susceptible to MAO metabolism.…”

Section: C-labeled Radiotracersmentioning

confidence: 99%

See 1 more Smart Citation

Cardiac Autonomic Nervous System and Ventricular Arrhythmias: The Role of Radionuclide Molecular Imaging

Fesas¹,

Giannoula

Vrachimis

et al. 2021

Diagnostics

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Widely established compared to myocardial perfusion imaging, cardiac autonomous nervous system (CANS) assessment by radiopharmaceutical means is of potential use especially to arrhythmogenic diseases not correlated with anatomic or functional alterations revealed by classical imaging techniques. Molecular imaging of both pre- and postsynaptic functions of the autonomous nervous system is currently feasible, since single photon emission tomography (SPECT) and positron emission tomography (PET) have the ability to reveal the insights of molecular pathophysiology depicting both sympathetic and parasympathetic imbalance in discrete heart pathologies. This review provides not only a brief presentation of radiopharmaceuticals used for non-invasive CANS imaging in the case of ventricular arrhythmias, but also a current update on ventricular tachycardias, cardiomyopathies, Brugada and Long QT syndrome literature.

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Section: Positron Emission Tomography (Pet) Radiotracersmentioning

confidence: 99%

Section: C-labeled Radiotracersmentioning

confidence: 99%