Quantification and spatial distribution of salicylic acid in film tablets using FT-Raman mapping with multivariate curve resolution

Eksi-Kocak, Haslet; Ilbasmiş-Tamer, Sibel; Yilmaz, Sebnem; Eryılmaz, Merve; Boyaci, İsmail Hakkı; Tamer, Uğur

doi:10.1016/j.ajps.2017.07.010

Cited by 20 publications

(10 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Imaging and mapping of APIs using vibrational spectroscopy methods have gained wide interest in the field of pharmaceutical formulation and process analytical technology. Vibrational spectroscopic techniques, infrared and Raman spectroscopy, allow the continuous monitoring of APIs during processing, which helps to evaluate the effect of formulation variables on the final product performance. , Recently, vibrational spectroscopy techniques have been employed in tablet dissolution studies in order to obtain a better understanding of the process of drug release from pharmaceutical formulations and to monitor drug distribution within it. , Since the Raman intensity of water is very weak compared to IR, Raman spectroscopy was chosen to monitor MS distribution between the dry core region and the hydrated gel layer during the time of swelling/dissolution. Raman spectra of pure MS, LCS, and XG were obtained to determine the characteristic Raman shifts to be used during mapping to distinguish MS from the polymeric mixture (Figure ).…”

Section: Resultsmentioning

confidence: 99%

“…67,68 Recently, vibrational spectroscopy techniques have been employed in tablet dissolution studies in order to obtain a better understanding of the process of drug release from pharmaceutical formulations and to monitor drug distribution within it. 69,70 Since the Raman intensity of water is very weak compared to IR, 71 Raman spectroscopy was chosen to monitor MS distribution between the dry core region and the hydrated gel layer during the time of swelling/dissolution. Raman spectra of pure MS, LCS and XG were obtained to determine the characteristic Raman shifts to be used during mapping to distinguish MS from the polymeric mixture ( Figure 9).…”

Section: Evaluation Of Drug Distribution During Dissolution Using Rammentioning

confidence: 99%

See 1 more Smart Citation

Elucidation of the Controlled-Release Behavior of Metoprolol Succinate from Directly Compressed Xanthan Gum/Chitosan Polymers: Computational and Experimental Studies

Dadou

El‐Barghouthi

Antonijević

et al. 2019

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

The development and evaluation of a controlled-release (CR) pharmaceutical solid dosage form comprising xanthan gum (XG), low molecular weight chitosan (LCS) and metoprolol succinate (MS) is reported. The research is, partly, based upon the utilization of computational tools; in this case molecular dynamics simulations (MDs) and response surface method (RSM), in order to underpin the design/prediction and to minimize the experimental work required to achieve the desired pharmaceutical outcomes. The capability of the system to control the release of MS was studied as a function of LCS (% w/w) and total polymer (LCS and XG) to drug ratio (P:D) at different tablet tensile strengths. MDs trajectories, obtained by using different ratios of XG:LCS as well as XG and high molecular weight CS (HCS), showed that the driving force for the interaction between XG and LCS is electrostatic in nature, the most favourable complex is formed when LCS is used at 15 % (w/w) and, importantly, that the interaction between XG and LCS is more favourable than that between XG and HCS. RSM outputs revealed that the release of the drug from the LCS/XG matrix is highly dependent on both the % LCS and the P:D ratio and that the required CR effect can be achieved when using weight fractions of LCS ≤ 20% and P:D ratios ≥ 2.6:1. Results obtained from in-vitro drug release and swelling studies on the prepared tablets showed that using LCS at the weight fractions suggested by MDs and RSM data plays a major role in overcoming the high sensitivity of the controlled drug release effect of XG on ionic strength and pH changes of the dissolution media. In addition, it was found that polymer relaxation is the major contributor to the release of MS from LCS-XG tablets. Using Raman spectroscopy, MS was shown to be localized more in the core of the tablets at the initial stages of dissolution due to film formation between LCS and XG on the tablet surface which prevents excess water penetration into the matrix. In the later stages of the dissolution process, the film starts to dissolve/erode allowing full tablet hydration and a uniform drug distribution in the swollen tablet.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Evaluation Of Drug Distribution During Dissolution Using Rammentioning

confidence: 99%

Elucidation of the Controlled-Release Behavior of Metoprolol Succinate from Directly Compressed Xanthan Gum/Chitosan Polymers: Computational and Experimental Studies

Dadou

El‐Barghouthi

Antonijević

et al. 2019

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

show abstract

“…For example, the particle size [ 8 , 9 ] and crystal form [ 10 , 11 ] strongly impact the dissolution [ 12 , 13 ] and, consequently, the oral bioavailability of APIs [ 14 ]. The spatial distribution of APIs in the excipient matrix is of good reference value for process development [ 15 , 16 ]. In this instance, reverse engineering of an RLD may facilitate the development of generic drugs by providing essential critical product attributes.…”

Section: Introductionmentioning

confidence: 99%

Raman Mapping-Based Reverse Engineering Facilitates Development of Sustained-Release Nifedipine Tablet

Sun

Chen²,

Lü

et al. 2022

Pharmaceutics

View full text Add to dashboard Cite

The development of generic preparations that are bioequivalent to a reference listed drug (RLD) is faced with challenges because some critical attributes of RLDs are commonly unknown to developers. In order to determine these attributes, Raman mapping-based reverse engineering in this study to analyze a model sustained-release tablet of nifedipine. The Raman mapping results indicate that the size and size distribution of nifedipine are critical to its release pattern and bioavailability. The tablets with a particle size of nifedipine comparable to that of a commercial product, Adalat®-L, showed similar in vitro release profiles to the RLD. Moreover, a pharmacokinetic study in human volunteers proved the bioequivalence of the two preparations. In conclusion, Raman mapping-based reverse engineering has the potential to facilitate the development of generic preparations.

show abstract

“…Indeed, MCR-ALS was successfully tested on voltametric signals to quantify organic acids in fruit juices and on UV-Vis spectra to discriminate polyphenols in a hibiscus extract [38][39][40][41]. It was also employed for quantification and spatial distribution of salicylic acid in filmcoated tablets using Raman spectrophotometry, or to get insight into conformational changes and protein folding [42,43]. MCR-ALS was also used for β-carotene with transient absorption spectroscopy to monitor its excited state as a function of time and also to automatize isoprenoids analysis by HPLC [44,45].…”

Section: Introductionmentioning

confidence: 99%

Feasibility of Individual Carotenoid Quantification in Mixtures Using UV-Vis Spectrophotometry with Multivariate Curve Resolution Alternating Least Squares (MCR-ALS)

Achir¹,

Servent

Soto

et al. 2022

Journal of Spectroscopy

View full text Add to dashboard Cite

A fast and low-cost analytical method to determine the concentrations of carotenoids (β-carotene, lutein, and lycopene) from mixed standard solutions or from fruit extracts (kiwi fruits, tomato paste, pink grapefruit juice, kiwi-pineapple smoothie, and apricot nectar) was tested. The methodology was based on UV-Vis spectrophotometry and Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS). Results showed that relative concentrations of β-carotene, lutein, and lycopene in solvent were successfully determined by this technique with an error inferior to 6%. In real extracts, the procedure succeeded well in identifying the major carotenoid type of the fruit samples but also a more complex profile of a fruit mixture. The results also showed that accuracy of carotenoids determination by UV-Vis spectrophotometry-MCR-ALS in fruit extracts was conditioned by their spectral characteristics (III/II ratios and λmax), their relative proportion, and the extract purity.

show abstract

Quantification and spatial distribution of salicylic acid in film tablets using FT-Raman mapping with multivariate curve resolution

Cited by 20 publications

References 33 publications

Elucidation of the Controlled-Release Behavior of Metoprolol Succinate from Directly Compressed Xanthan Gum/Chitosan Polymers: Computational and Experimental Studies

Elucidation of the Controlled-Release Behavior of Metoprolol Succinate from Directly Compressed Xanthan Gum/Chitosan Polymers: Computational and Experimental Studies

Raman Mapping-Based Reverse Engineering Facilitates Development of Sustained-Release Nifedipine Tablet

Feasibility of Individual Carotenoid Quantification in Mixtures Using UV-Vis Spectrophotometry with Multivariate Curve Resolution Alternating Least Squares (MCR-ALS)

Contact Info

Product

Resources

About