QuantiFERON-TB Testing for Latent Tuberculosis Infection in Low-Prevalence Countries: Making the Most of an Imperfect Process

Schneider, W.; Brown, Arthur E.; Eisenstein, Cynthia

doi:10.1086/662022

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…Patients with influenza who require hospitalisation tend not to present with classic influenza-like illness (ILI), therefore relying on ILI presentations to identify patients suffering serious influenza infections or influenza-related complications is inadequate [10]. A substantial proportion of patients admitted to intensive care with pneumonia or respiratory infection are found to be positive for influenza, if an appropriate test is performed in a timely manner [11].…”

Section: Introductionmentioning

confidence: 99%

The impact of influenza A(H1N1)pdm09 compared with seasonal influenza on intensive care admissions in New South Wales, Australia, 2007 to 2010: a time series analysis

et al. 2012

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BackgroundIn Australia, the 2009 epidemic of influenza A(H1N1)pdm09 resulted in increased admissions to intensive care. The annual contribution of influenza to use of intensive care is difficult to estimate, as many people with influenza present without a classic influenza syndrome and laboratory testing may not be performed. We used a population-based approach to estimate and compare the impact of recent epidemics of seasonal and pandemic influenza.MethodsFor 2007 to 2010, time series describing health outcomes in various population groups were prepared from a database of all intensive care unit (ICU) admissions in the state of New South Wales, Australia. The Serfling approach, a time series method, was used to estimate seasonal patterns in health outcomes in the absence of influenza epidemics. The contribution of influenza was estimated by subtracting expected seasonal use from observed use during each epidemic period.ResultsThe estimated excess rate of influenza-associated respiratory ICU admissions per 100,000 inhabitants was more than three times higher in 2007 (2.6/100,000, 95% CI 2.0 to 3.1) than the pandemic year, 2009 (0.76/100,000, 95% CI 0.04 to 1.48). In 2009, the highest excess respiratory ICU admission rate was in 17 to 64 year olds (2.9/100,000, 95% CI 2.2 to 3.6), while in 2007, the highest excess rate was in those aged 65 years or older (9.5/100,000, 95% CI 6.2 to 12.8). In 2009, the excess rate was 17/100,000 (95% CI 14 to 20) in Aboriginal people and 14/100,000 (95% CI 13 to 16) in pregnant women.ConclusionWhile influenza was diagnosed more frequently and peak use of intensive care was higher during the epidemic of pandemic influenza in 2009, overall excess admissions to intensive care for respiratory illness was much greater during the influenza season in 2007. Thus, the impact of seasonal influenza on intensive care use may have previously been under-recognised. In 2009, high ICU use among young to middle aged adults was offset by relatively low use among older adults, and Aboriginal people and pregnant women were substantially over-represented in ICUs. Greater emphasis on prevention of serious illness in Aboriginal people and pregnant women should be a priority in pandemic planning.

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Section: Introductionmentioning

confidence: 99%

The impact of influenza A(H1N1)pdm09 compared with seasonal influenza on intensive care admissions in New South Wales, Australia, 2007 to 2010: a time series analysis

et al. 2012

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“…Thus, while both TST and IGRAs are impacted by nonspecific variations, conversions and reversions during serial testing, IGRAs appear to have a very high frequency of conversions and reversions, and the consequences of such changes are unclear, posing challenges for implementation in routine occupational health programs. Indeed, a series of recent studies have described the challenges faced by US hospitals that switched to IGRA for HCW screening after the 2005 CDC guideline (15,17,(25)(26)(27)(28).…”

mentioning

confidence: 99%

Interferon-Gamma Release Assays for Screening of Health Care Workers in Low Tuberculosis Incidence Settings: Dynamic Patterns and Interpretational Challenges

Pai

Elwood

2012

Canadian Respiratory Journal

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QuantiFERON-TB Testing for Latent Tuberculosis Infection in Low-Prevalence Countries: Making the Most of an Imperfect Process

Cited by 2 publications

References 5 publications

The impact of influenza A(H1N1)pdm09 compared with seasonal influenza on intensive care admissions in New South Wales, Australia, 2007 to 2010: a time series analysis

The impact of influenza A(H1N1)pdm09 compared with seasonal influenza on intensive care admissions in New South Wales, Australia, 2007 to 2010: a time series analysis

Interferon-Gamma Release Assays for Screening of Health Care Workers in Low Tuberculosis Incidence Settings: Dynamic Patterns and Interpretational Challenges

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