Quality of Transfusion Products in Blood Banking

Franchini, Massimo; Capuzzo, Enrico; Turdo, Rosalia; Glingani, Claudia

doi:10.1055/s-0034-1365840

Cited by 12 publications

(12 citation statements)

References 14 publications

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“…[ 2 3 ] In the modern blood banking, quality controls of blood products ensure the timely availability of a blood component of high-quality yield with maximum efficacy and minimal risk to potential recipients. [ 4 ] Processes and manuals are need to be highly focused on generating quality blood components that are more efficacious and safe. The primary component in the quality control system is blood donation, which is collected from prospective donors of various ages with different demographics, health profiles, and risk behaviors.…”

Section: Introductionmentioning

confidence: 99%

Internal quality control of blood products: An experience from a tertiary care hospital blood bank from Southern Pakistan

et al. 2018

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INTRODUCTION:Internal quality control (IQC) is the backbone of quality assurance program. In blood banking, the quality control of blood products ensures the timely availability of a blood component of high quality with maximum efficacy and minimal risk to potential recipients. The main objective of this study is to analyze the IQC of blood products as an indicator of our blood bank performance.METHODS:An observational cross-sectional study was conducted at the blood bank of Liaquat National Hospital and Medical College, from January 2014 to December 2015. A total of 100 units of each blood components were arbitrarily chosen during the study. Packed red cell units were evaluated for hematocrit (HCT); random platelet concentrates were evaluated for pH, yield, and culture; fresh frozen plasma (FFP) and cryoprecipitate (CP) were evaluated for unit volume, factor VIII, and fibrinogen concentrations.RESULTS:A total of 400 units were tested for IQC. The mean HCT of packed red cells was 69.5 ± 7.24, and in 98% units, it met the standard (<80% of HCT). The mean platelet yield was 8.8 ± 3.40 × 109/L and pH was ≥6.2 in 98% bags; cultures were negative in 97% of units tested. Mean factor VIII and fibrinogen levels were found to be 84.24 ± 15.01 and 247.17 ± 49.69 for FFP, respectively. For CP, mean factor VIII and fibrinogen level were found to be 178.75 ± 86.30 and 420.7 ± 75.32, respectively.CONCLUSION:The IQC of blood products at our blood bank is in overall compliance and met recommended international standards. Implementation of standard operating procedures, accomplishment of standard guidelines, proper documentation with regular audit, and staff competencies can improve the quality performance of the transfusion services.

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Section: Introductionmentioning

confidence: 99%

Internal quality control of blood products: An experience from a tertiary care hospital blood bank from Southern Pakistan

et al. 2018

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“…Improved quality testing over the period has resulted in safer transfusion practices and decrease adverse outcomes. 6 The aim of quality control measures is to ensure supply of safe and efficient blood transfusion to the patient and to prevent transfusion transmitted diseases.…”

Section: Discussionmentioning

confidence: 99%

“…Processes and manuals are needed to be highly focused on generating quality blood components that are more efficacious and safe. 6 In recent years, there have been significant developments, aimed at improving the quality of the blood components. There have been advancement and progression in international standards for blood components and principles of high‑quality manufacturing practices have been redefined to provide the framework for quality in BTSs.…”

Section: Introductionmentioning

confidence: 99%

Internal quality control in blood and component bank in a tertiary healthcare center in Northern India

Arora¹,

Malik²,

Parashar³

et al. 2021

JDPO

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Quality control describes steps taken by blood and component bank to ensure that tests are performed correctly. Primary goal of quality control is transfusion of safe quality of blood. It is to ensure availability of efficient supply of blood and blood components. Internal quality control is the backbone of quality assurance program. To analyze the internal quality control of blood components in modern blood banking as an indicator of our blood bank performance. An observational cross sectional study conducted at the Blood and Component Bank, JN Medical College and Hospital from 2018 to 2020. Each blood component was arbitrarily chosen during the study on monthly basis. Selection criteria was 1.0% of total collection or minimum 4 bags per month. Packed red cells were evaluated for hemoglobin, hematocrit, RBC count; platelet concentrates for pH, yield and culture; fresh frozen plasma and cryoprecipitate were evaluated for unit volume, factor VIII and fibrinogen concentration. The mean HCT of packed red cells was 65.75+7.42%, volume was 238+26.25ml, Hb was 20.5+0.15g/dL and RBC count of 5.89x10+0.30x10. The mean platelet yield was 5.7x10, pH was ≥6.8+0.175 and volume was 82.5+13.75ml; cultures were negative and swirling was present in all the platelet units tested. Mean factor VIII and fibrinogen levels were found to be 95.25 +7.37and 307.5+41.37gm/l for FFP respectively. Mean volume, PT and APTT were 215+32.5ml, 14.15+0.325 sec and 29.50+1.5 sec respectively. The quality control of blood components ensures the timely availability of a blood component of high quality with maximum efficacy and minimal risk to potential recipients.

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“…One of the main goals of transfusion medicine is to provide a safe and effective supply of blood products for the treatment or prevention of disease. Blood components, including red blood cells, fresh frozen plasma, and platelet concentrates are destined to go to patients affected by malignant and nonmalignant diseases, trauma, and sepsis, and for use in complex cardiac, orthopaedic and transplantation surgeries [ 1 ]. The collection, testing, processing, storage, and distribution of blood components to patients involves complex procedures supported by specific guidelines in order to ensure transfusion safety and efficacy [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Overview of Cellular Immunotherapies within Transfusion Medicine for the Treatment of Malignant Diseases

Tešić

Poženel

Švajger

2021

IJMS

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Over the years, transfusion medicine has developed into a broad, multidisciplinary field that covers different clinical patient services such as apheresis technology and the development of stem cell transplantation. Recently, the discipline has found a niche in development and production of advanced therapy medicinal products (ATMPs) for immunotherapy and regenerative medicine purposes. In clinical trials, cell-based immunotherapies have shown encouraging results in the treatment of multiple cancers and autoimmune diseases. However, there are many parameters such as safety, a high level of specificity, and long-lasting efficacy that still need to be optimized to maximize the potential of cell-based immunotherapies. Thus, only a few have gained FDA approval, while the majority of them are studied in the context of investigator-initiated trials (IITs), where modern, academically oriented transfusion centers can play an important role. In this review, we summarize existing and contemporary cellular immunotherapies, which are already a part of modern transfusion medicine or are likely to become so in the future.

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Quality of Transfusion Products in Blood Banking

Cited by 12 publications

References 14 publications

Internal quality control of blood products: An experience from a tertiary care hospital blood bank from Southern Pakistan

Internal quality control of blood products: An experience from a tertiary care hospital blood bank from Southern Pakistan

Internal quality control in blood and component bank in a tertiary healthcare center in Northern India

Overview of Cellular Immunotherapies within Transfusion Medicine for the Treatment of Malignant Diseases

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