Quality of survival assessment in European childhood brain tumour trials, for children below the age of 5 years

Limond, Jennifer; Thomas, Sophie; Bull, Kim; Calaminus, Gabriele; Lemiere, Jurgen; Traunwieser, Thomas; Santen, Hanneke M van; Weiler, Larry; Spoudeas, Helen; Chevignard, Mathilde

doi:10.1016/j.ejpn.2019.10.002

Cited by 18 publications

(15 citation statements)

References 41 publications

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“…Survivors of paediatric brain tumours have been shown to suffer from more cognitive fatigue compared to survivors of leukaemia (Irestorm, Tonning Olsson, Johansson, & Ora, 2020;Meeske et al, 2004;Mulrooney et al, 2008). While most follow-up protocols after cancer treatment do not yet include measurements of fatigue, there is an increased demand for including it in followup protocols for survivors of both paediatric and adult cancer (Berger, Mitchell, Jacobsen, & Pirl, 2015;Irestorm et al, 2020;Limond et al, 2020;Tomlinson et al, 2013). Cancer-related fatigue has consistently been found to be one of the most prevalent and distressing symptoms in childhood cancer survivors (Kanellopoulos, Hamre, Dahl, Fossa, & Ruud, 2013;Meeske, Patel, Palmer, Nelson, & Parow, 2007;Spathis et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Cognitive Fatigue and Processing Speed in Children Treated for Brain Tumours

Irestorm

Öra

Linge

et al. 2021

J Int Neuropsychol Soc

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Objective: The relationship between fatigue and cognition has not been fully elucidated in children and adolescent survivors of brain tumours. The aim of the present study was to investigate the potential relationship between fatigue and cognitive impairments in these survivors, as this group is at risk for both types of deficits. Methods: Survivors of paediatric brain tumours (n = 45) underwent a neuropsychological testing on average 4 years after diagnosis. Mean age at follow-up was 13.41 years. Cognition was assessed with neuropsychological tests, and fatigue with the Pediatric Quality of Life (PedsQL™) Multidimensional Fatigue Scale. Regression analysis, adjusted for cranial radiotherapy and age at diagnosis, was used to investigate the associations between cognitive variables and fatigue subscales. Cognitive variables associated with fatigue were subsequently exploratively assessed. Results: Significant associations were found for cognitive fatigue and measures of cognitive processing speed; Coding: p = .003, r = .583, 95% CI [9.61; 22.83] and Symbol Search: p = .001, r = .585, 95% CI [10.54; 24.87]. Slower processing speed was associated with poorer results for cognitive fatigue. Survivors with the largest decrease in processing speed from baseline to follow-up also experienced the most cognitive fatigue. Survivors expressed more cognitive fatigue compared to other types of fatigue. Conclusions: The association between cognitive fatigue and cognitive processing speed in children and adolescents treated for brain tumours is in concordance with the results previously reported in adults. Some survivors experience fatigue without impairment in processing speed, indicating the need for comprehensive assessments. Moreover, the study supports that fatigue is a multidimensional concept which should be measured accordingly.

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Section: Introductionmentioning

confidence: 99%

Cognitive Fatigue and Processing Speed in Children Treated for Brain Tumours

Irestorm

Öra

Linge

et al. 2021

J Int Neuropsychol Soc

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“…A detailed analysis of direct and indirect measures of cognitive functioning is beyond the scope of this review (for a detailed battery of neuropsychological tests for children below 5 years and 5 years and over, see, respectively, [ 87 ] and [ 88 ]).…”

Section: Strategy Of Monitoring and Potential Interventionmentioning

confidence: 99%

“…At all ages, there are issues with the optimal timing of baseline assessment, which can potentially be performed at diagnosis, before surgery, before radiotherapy, or even after treatments [ 87 ].…”

Section: Strategy Of Monitoring and Potential Interventionmentioning

confidence: 99%

Neuropsychological Outcomes of Children Treated for Brain Tumors

Pancaldi

Pugliese²,

Migliozzi³

et al. 2023

Children

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Central nervous system (CNS) neoplasms are the most common solid tumors diagnosed in children. CNS tumors represent the leading cause of cancer death and cancer-related morbidity for children less than 20 years of age, although there has been a moderate increase in survival rates over the past several decades. The average survival at 5 years now nearly reaches 75%, and for some, non-malignant histology approximates 97% at 20 years from diagnosis. Neurological, cognitive, and neuropsychological deficits are the most disabling long-term effects of brain tumors in children. Childhood is a time of extreme brain sensitivity and the time of life in which most brain development occurs. Thus, the long-term toxicities that children treated for CNS tumors experience can affect multiple developmental domains and day-to-day functioning, ultimately leading to a poor quality of survival (QoS). We reviewed literature focusing on the risk factors for cognitive and neuropsychological impairment in pediatric patients treated for brain tumors with the aim of better understanding who is at major risk and what the best strategies for monitoring these patients are.

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“…Эта батарея тестов была сформирована группой ученых Европейского общества детской нейроонкологии, которые в течение 8 лет анализировали национальный опыт 11 европейских стран по оценке последствий лечения опухолей ЦНС, а также использовался опыт работы исследователей Северной Америки [4,5]. Предлагаемая конструкция для оценки последствий опухолей головного мозга была определена в процессе группового соглашения, а также на основе обсуждения современной литературы и клинического опыта.…”

Section: Abstract: Cognitive Functions Measurement Tests Rationingunclassified

“…В результате обработки данных программой SPSS v.23, были получены распре-деления результатов для каждой возрастной категории (табл. [3][4][5][6].…”

Section: результаты исследования и их обсуждениеunclassified

Preliminary Results of Normalization of a Complex of Methods for Cognitive Sphere Assessment in Children

Glebova¹,

Kasatkin²,

Likhomanova³

et al. 2018

IJAFR (МЖПФИ)

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Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачёва, Москва, e-mail: apple89@mail.ru; 2 Научно-клинический многопрофильный центр медицинской помощи матерям и детям им. З.И. Круглой, ОрелПроблема адаптации и стандартизации психологических методик стоит в нашей стране достаточно остро, особенно это касается их использования для специфических групп детей, таких как дети, перенесшие онкологические заболевания. Согласно статистике до 40 % детей после лечения онкологических заболеваний имеют стойкие когнитивные нарушения, а в группе детей, перенесших опухоли головного мозга (ОГМ), этот процент значительно выше. Мониторирование этого процесса позволит как можно раньше отслеживать возможные нарушения в когнитивной сфере не только для оценки токсических эффектов лечения, но и для оказания своевременной помощи нейрокогнитивной реабилитации. По наиболее проблемной группе, детей с ОГМ, был достигнут консенсус по использованию стандартного набора тестовых методик для оценки таких психических функций, как скорость обработки, мелкая моторика, внимание, память, зрительно-пространственное восприятие, исполнительные функции, мышление. В нашей стране нет нормативных показателей по этим методикам, поэтому целью данной работы было нормирование этой батареи на российской выборке. В настоящей работе представлены результаты по 1-му этапу. В исследование приняли участие школьники начальных классов г. Орла. Были получены результаты по 12 тестам для 4-х возрастных категорий (7, 8, 9 и 10 лет). Эти данные можно рассматривать как предварительные, так как для получения отечественных норм необходимо увеличить объем выборки и сделать её более репрезентативной. Однако проведенное исследование показало перспективность использования этой батареи как в клинике, так и для здоровых детей. Ключевые слова: когнитивные функции, измерение, тесты, нормирование, возрастная психология, детская онкология ; 2 Scientific and clinical multidisciplinary center for medical care for mothers and children Z.I. Kruglaya, Orel Рис. 12. Выполнение батареи когнитивных тестов младшими школьниками

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Quality of survival assessment in European childhood brain tumour trials, for children below the age of 5 years

Cited by 18 publications

References 41 publications

Cognitive Fatigue and Processing Speed in Children Treated for Brain Tumours

Cognitive Fatigue and Processing Speed in Children Treated for Brain Tumours

Neuropsychological Outcomes of Children Treated for Brain Tumors

Preliminary Results of Normalization of a Complex of Methods for Cognitive Sphere Assessment in Children

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