Quality of Sulfadoxine-Pyrimethamine Given as Antimalarial Prophylaxis in Pregnant Women in Selected Health Facilities in Central Region of Ghana

Yeboah, Danny Flint; Afoakwah, Richmond; Nwaefuna, Ekene K.; Orish, Verner N.; Boampong, Johnson Nyarko

doi:10.1155/2016/9231946

Cited by 11 publications

(14 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another possible reason is the availability of poor quality sulfadoxine–pyrimethamine; some SP drugs on the Ghanaian market have been found to be of low quality. A recent study found 2 out of 3 SP drugs given at hospitals in the Central region of Ghana to pregnant women failed the drug dissolution test, even though they contained the active ingredient [ 43 ]. This means that the amount of the drug that was able to dissolve within a particular period and be available for absorption in the body was very low; the drugs were therefore not effective [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Plasmodium falciparum and non-P. falciparum infections in a highland district in Ghana, and the influence of HIV and sickle cell disease

Owusu

Brown

Grobusch

et al. 2017

Malar J

View full text Add to dashboard Cite

BackgroundIn the past two decades, there has been a reported decline in malaria in Ghana and the rest of the world; yet it remains the number one cause of mortality and morbidity. Human immuno-deficiency virus (HIV) and sickle cell disease (SCD) share a common geographical space with malaria in sub-Saharan Africa and an interaction between these three conditions has been suggested. This study determined the Plasmodium falciparum and non-P. falciparum status of symptomatic and non-symptomatic residents of Mpraeso in the highlands of Kwahu-South district of Ghana based on evidence of current national decline. The influence of HIV and SCD on malaria was also determined.MethodsParticipants were 354 symptomatic patients visiting the Kwahu Government Hospital and 360 asymptomatic residents of the district capital. This cross-sectional study was conducted during the minor rainy season (October–December 2014). Rapid diagnostic tests (RDT), blood film microscopy and real-time polymerase chain reaction assessment of blood were done. Participants who tested positive with RDT were treated with artemisinin-based combination therapy; and assessment of venous blood was repeated 7 days after treatment. HIV screening and haemoglobin genotyping was done. Univariate and multivariate regression analysis was used to determine the influence of SCD and HIV.Results Plasmodium falciparum was prevalent at 124/142 (87.3%). Plasmodium malariae was the only non-falciparum species detected at 18/142 (12.7%). HIV and SCD did not significantly increase odds of malaria infection. However, the use of ITN and recent anti-malarial intake significantly decreased the odds of being malaria infected by 0.45-fold and 0.46-fold respectively.Conclusion Plasmodium falciparum and P. malariae infection are the prevailing species in the study area; albeit varying from the national average. HIV and SCD were not associated with the risk of having malaria.Electronic supplementary materialThe online version of this article (doi:10.1186/s12936-017-1823-y) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 99%

Prevalence of Plasmodium falciparum and non-P. falciparum infections in a highland district in Ghana, and the influence of HIV and sickle cell disease

Owusu

Brown

Grobusch

et al. 2017

Malar J

View full text Add to dashboard Cite

show abstract

“…In Ghana, Yeboah et al found a malaria prevalence of 11.2% in women who received IPT with SP and have thus questioned the efficacy of the treatment. 31 Single marital status was associated with malaria infection in these patients. Singles areusually young and more prone to malaria infection compared with older women since they are still in the process of acquiring immunity against malaria.…”

Section: Discussionmentioning

confidence: 86%

Assessment of labor and delivery in pregnant women on sulfadoxine-pyrimethamine regimen in Yaoundé gynaeco-obstetric and paediatric hospital: a comparative study of 313 cases

Foumane

Essiben

Dohbit

et al. 2017

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

Background: Malaria is still a major public health problem in sub-Saharan Africa. The aim was to determine the prevalence of malaria infection at the onset of labor and the resulting complications.Methods: We carried out a five-month cross-sectional study at the Yaoundé Gyneco-Obstetric and Pediatric Hospital. We used results from the rapid diagnostic test (RDT) to compare two groups of pregnant women admitted into the labor room. Women who tested positive were assigned to the exposed group versus negative to the non-exposed group. Independent factors associated with malaria infection were investigated by the logistic regression method.Results: Up to 79.6% (249/313) of women had received the sulfadoxin-pyrimethamine regimen with 32.9% (82/249) receiving at least 3 doses. Malaria infection was detected in 32.2% (101/313) of women. Only 14.9% (15/101) of the exposed group had received 3 doses of SP versus 31.6% (67/212) of the non-exposed group. After univariate analysis, malaria infection at the onset of labor was associated to premature rupture of membranes (OR=1.39; CI=1.01-1.94), fever during labor (OR=73.37; CI=64.80-681.95), non-reassuring fetal status (OR=2.08; CI=1.36-3.20), low birth weight (OR=1.65; CI=1.23-4.13), prematurity (OR=2.79; CI=2.12-367), a poor Apgar score at the 1st minute and postpartum fever (OR=3.19; CI=2.56-4.00). Linear logistic regression indicated that the occurrence of fever during labor (aOR=63.09), and low Apgar score at the first minute (aOR=6.27) remained significant and malaria infection was significantly associated to the single marital status (aOR=2.56) and a history of malaria during the current pregnancy (aOR=2.56).Conclusions: Systematic RDTs is thus recommended at the last antenatal consultation to avoid identified complications.

show abstract

“…As a result, the first line of drug for the treatment of P. falciparum malaria cases was changed from sulfadoxinepyrimethamine to artemether lumefantrine after the mentioned year as above [36]. For instance, one study conducted in Ghana showed that sulfadoxine-pyrimethamine was substandard in treating malaria cases [74]. In areas where SP implementation, growing resistance to sulfadoxine-pyrimethamine is an emerging challenge [75].…”

Section: Treatment Strategies Of Malariamentioning

confidence: 99%

“…In areas where SP implementation, growing resistance to sulfadoxine-pyrimethamine is an emerging challenge [75]. In contrast, using sulfadoxine-pyrimethamine (SP) as an intermittent preventive therapy against the disease during pregnancy is becoming a policy in most sub-Sahara African regions before years [74].…”

Section: Treatment Strategies Of Malariamentioning

confidence: 99%

Malaria: What are the Needs for Diagnosis, Treatment and Control?

Molla¹,

Ayele²

2016

Biol Med (Aligarh)

View full text Add to dashboard Cite

According to the World Health Organization, malaria has been noted for many years in the world causing a life threatening effects. Despite progress in fighting malaria worldwide, the disease kills 236,000-635,000 peoples annually. The objective of this review is to indicate the current situations of malaria on epidemiology, clinical presentations, diagnosis, treatment approach and control strategies, with enumerating the identified challenges. Literatures and available information written on the malaria epidemiology, clinical manifestation, diagnosis, treatment and control strategies were reviewed from different electronic archives of institutional websites and databases such as Scopus, HINARI, Pub Med, Scopus, Medline and Google scholar sources. Children less than five years of age living in Sub-Saharan Africa are mainly the affected groups. Although rapid diagnostic and molecular tests for malaria are increasing in prevalence and importance, the standard method for malaria diagnosis in much of the world remains microscopy. As recommended by the World Health Organization, the management of suspected malaria cases relies on early diagnosis and effective treatment based on artemisinin-combined therapy. Likewise, including Ethiopia, most Sub-Saharan African countries with Plasmodium falciparum malaria has adopted artemisinin-combined therapies as a first-line treatment; with Arthemeter Lumefantrine now the first line treatment for uncomplicated falciparum malaria in Ethiopia. In areas where chloroquine is still effective, P. vivax malaria should be treated with this drug. Where resistance to chloroquine has been documented, P. vivax malaria should be treated with an appropriate artemisinin-combined therapy. Most reviews and findings revealed that the control and elimination of malaria require expanded coverage of and access to effective malaria control interventions such as insecticide-treated nets, indoor residual spraying, intermittent preventive treatment, diagnostic testing and appropriate treatment. In malaria endemic areas, parasite resistance to most commonly used anti-malarial drugs, poor community participation, the absence of new technologies for effective control and eradication, difficulties on the diagnostic tools, insecticide resistance in the vector and changing of biting behavior of the vectors are involving problems to eradicate malaria. More operational researches and adapted evaluation methods are needed to better address challenges for malaria control and elimination. In addition, the global malaria community needs to work together, to ensure the early steps towards malaria eradication.

show abstract

Quality of Sulfadoxine-Pyrimethamine Given as Antimalarial Prophylaxis in Pregnant Women in Selected Health Facilities in Central Region of Ghana

Cited by 11 publications

References 20 publications

Prevalence of Plasmodium falciparum and non-P. falciparum infections in a highland district in Ghana, and the influence of HIV and sickle cell disease

Prevalence of Plasmodium falciparum and non-P. falciparum infections in a highland district in Ghana, and the influence of HIV and sickle cell disease

Assessment of labor and delivery in pregnant women on sulfadoxine-pyrimethamine regimen in Yaoundé gynaeco-obstetric and paediatric hospital: a comparative study of 313 cases

Malaria: What are the Needs for Diagnosis, Treatment and Control?

Contact Info

Product

Resources

About