Quality of sleep and associated factors among people living with HIV/AIDS on follow up at Ethiopian Zewditu Memorial Hospital,2018

Mengistu, Nebiyu; Azale, Telake; Yimer, Solomon; Fikreyesus, Mahilet; Melaku, Elsa; Shumye, Seid

doi:10.21203/rs.3.rs-26745/v3

Cited by 2 publications

(2 citation statements)

References 29 publications

(50 reference statements)

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“…The study was part of a large cohort study aimed at reporting the prevalence data. ZMH is the rst hospital inaugurated as well as initiated ART service in Ethiopia, July 2003 [28,29].…”

Section: Study Design Period and Settingmentioning

confidence: 99%

Biomarkers and prevalence of cardiometabolic syndrome among people living with HIV/AIDS, Addis Ababa, Ethiopia: a hospital-based, observational study.

Woldu¹,

Minzi²,

Shibeshi³

et al. 2021

Preprint

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Background Although marked improvements in life expectancy have been observed with the rapid expansion of Antiretroviral Therapy (ART), Cardiometabolic Syndrome (CMetS) is becoming a serious challenge for People Living with HIV/AIDS (PLWHA). The present study aimed in determining biomarkers and prevalence of CMetS in PLWHA. Methods A hospital-based, observational study was carried out between January 2019 & February 2020 among HIV infected adults (n = 288). Binary logistic regression was used to estimate odds ratio (OR) and corresponding 95% confidence interval (CI) for the association between the outcomes against the predictor variables. Results The current study revealed that the prevalence of CMetS was 28.5% (82/288) using the National Cholesterol Education Program (NCEP)-2005 definition; and it was 43.5% (126/288) using the International Diabetes Federation (IDF)-2005. Male gender was less likely to be associated with CMetS (OR = .086, C.I. 0.025–0.292, p < 0.001) using the NCEP-2005 definition. Individuals with longer duration on ART have an increased odds of CMetS using both the NCEP-2005 (OR = 1.024, C.I. 1.005–1.043, p = 0.014) and the IDF-2005 (OR = 1.251, C.I. 1.061–1.472, p = 0.007) definitions. The age at which ART initiated yet have an impact on the outcomes of CMetS (NCEP-2005: OR = 1.27, C.I. 1.031–1.564, p = 0.025), indicating that individuals who started ART treatment at older age are more likely to have CMetS than their younger counterparts. The study further verified that, individuals with increased waist-grid (central adiposity) were more likely to have CMetS using both the NCEP-2005 (OR = 1.21, C.I. 1.029–1.418, p = 0.021) and the IDF-2005 (OR = 1.730 C.I. 1.454–2.058, p < 0.001) definitions. PLWHA with increased in DBP (OR = 1.164, C.I.1.080–1.254, p < 0.001), Triglyceride (OR = 1.027, C.I. 0.015–0.039, p < 0.001), and low density lipoproteins (OR = 1.075, C.I. 0.020–0.134, p = 0.007) were more likely to have CMetS using the NCEP-2005 definition. PLWHA without comorbidity were less likely to have CMetS (NCEP-2005: OR = 0.086, C.I. 0.025–0.292, p < 0.001). Conclusions The prevalence of CMetS in the study area was high. Risk factors associated with CMetS were waist circumference, gender, duration on ART; ART initiated age, waist-grid, and comorbidity. Biomarkers that were more likely contributed to the prevalence of CMetS include triglyceride, low density lipoproteins, and systolic blood pressure.

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“…The study was part of a large cohort study aimed at reporting the prevalence data. ZMH is the rst hospital inaugurated as well as initiated ART service in Ethiopia, July 2003 [28,29].…”

Section: Study Design Period and Settingmentioning

confidence: 99%

Biomarkers and prevalence of cardiometabolic syndrome among people living with HIV/AIDS, Addis Ababa, Ethiopia: a hospital-based, observational study.

Woldu¹,

Minzi²,

Shibeshi³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…ZMH was the rst hospital to commence and initiate the subsidized-fee-based scheme ART service in Ethiopia, in July 2003. Currently, there are about 7,674 active adults and around 2,558 children in its follow-up nest [20].…”

Section: Study Design Period and Settingmentioning

confidence: 99%

Estimation of the 10-Year Atherosclerotic Cardiovascular Disease and The Framingham Risk Score Among Adults Living with HIV/AIDS in Addis Ababa, Ethiopia: A Hospital-Based, Observational Study.

Woldu¹,

Minzi²,

Shibeshi³

et al. 2021

Preprint

View full text Add to dashboard Cite

Background With a much improved ART of the present day, most morbidities and mortalities in people living with HIV/AIDS (PLWHA) are associated with factors such as non-infectious diseases (NIDs) in the form of coronary heart disease (CHD). This study aimed at determining the prevalence and predictors of coronary heart disease (CHD) using the 10-year atherosclerotic cardiovascular disease (ASCVD) and Framingham risk score (FRS) tools among PLWHA. Methods A hospital-based, observational study was carried out from January 2019 to February 2020 in HIV infected adults. Prevalence of FRS (age 20 to 79) was determined using the National, Heart, Lung and Blood Institute (NHLBI) and prevalence of ASCVD (age 40 to 79) was determined using the peer-reviewed online (ClinCalc.com) tool. Results Using the 10-years ASCVD risk estimation 27.3% of the study participants had an elevated risk > 7.5 % CHD. Similarly using the 10-year FRS, 1.4 % had high-risk score of developing CHD. Using multiple linear regression analysis age (β = .061, p < .001), gender (β = .816, p < .001), systolic blood pressure (β = .21, p < .001), total cholestrol (β = .002, p = .001), high density lipoprotein (β = − .02, p < .001), and Tobacco use (β = .559, p < .001) had significant contribution to the risk of CHD using the ASCVD tool, while using binary logistic regression for the FRS tool, gender (OR = 26.105, 95% C.I. [6.110, 111,543], p < 0.001), age (OR = 1.293, 95% C.I. [1.181, 1.415], P < 0.001), and low HDL-C (OR = 0.887, 95% C.I. [.786, .979], P = 0.19) had significant contribution. Conclusions The prevalence of high-risk CHD among PLWHA using the FRS and ASCVD tools were 1.4 & 27.3 percent respectively. In both the tools advanced age, male gender, and low level HDL were significant contributor for the risk of CHD in PLWHA.

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Quality of sleep and associated factors among people living with HIV/AIDS on follow up at Ethiopian Zewditu Memorial Hospital,2018

Cited by 2 publications

References 29 publications

Biomarkers and prevalence of cardiometabolic syndrome among people living with HIV/AIDS, Addis Ababa, Ethiopia: a hospital-based, observational study.

Biomarkers and prevalence of cardiometabolic syndrome among people living with HIV/AIDS, Addis Ababa, Ethiopia: a hospital-based, observational study.

Estimation of the 10-Year Atherosclerotic Cardiovascular Disease and The Framingham Risk Score Among Adults Living with HIV/AIDS in Addis Ababa, Ethiopia: A Hospital-Based, Observational Study.

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