Quality of life profile in Italian long-term cancer survivors

Muzzatti, Barbara; Flaiban, Cristiana; Surbone, Antonella; Annunziata, Maria Antonietta

doi:10.1007/s11136-014-0831-4

Cited by 18 publications

(20 citation statements)

References 29 publications

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“…Participants with better education and still working participants have both showed better Physical functioning, less Role limitations (due to physical or emotional problems), less Bodily pain, and better General health with respect to their counterparts. These data are not surprising; they expand and complement what was found in previous studies [1,15,21,22]. For example, in a study involving 24,810 US adults with self-reported physician diagnosis of cancer and 382,837 US adults with no cancer history, Clarke et al [22]showed how the non-working active cancer subsample, compared to those who claimed not to be, more often reported good or excellent health (although in a smaller percentage than the controls without any experience of cancer).…”

Section: Discussionsupporting

confidence: 91%

“…In line with that which has already been described in the literature [1,15,16], there are gender differences. In the present study, women showed worse Physical functioning, more Bodily pain, Vitality, and worse Mental health.…”

Section: Discussionsupporting

confidence: 86%

“…However, it should be mentioned as other studies (for example [18]) showed that education was not associated with QoL. Finally, as already described elsewhere [1,12,15,17,18,23,24], those who reported having other health problems showed a worse quality of life in all domains considered (except in Mental health, in the present study).…”

Section: Discussionsupporting

confidence: 78%

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Long-term quality of life profile in oncology: a comparison between cancer survivors and the general population

Annunziata

Muzzatti

Flaiban

et al. 2017

Support Care Cancer

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Purpose Understanding the quality of life (QoL) of cancer survivors is relevant to both clinical practice and health care policy. The current study compared the QoL profile in this specific population with that of a normative sample for the general population, as well as with those of both healthy and oncological patients normative sub-samples. In addition, associations between the obtained QoL profile and the main socio-demographic and clinical characteristics of the sample were examined. Methods Three hundred and ninety-two adult long-term cancer survivors (i.e., people 5 + years from their cancer diagnosis who were free from it and its treatments) were enrolled during follow-up visits and compiled the Short Form 36 Health Survey. Results In comparison with the normative data for the adult general population, the present sample showed lower scores in Physical functioning, Role-physical limitation, and Roleemotional limitations (all differences were both statistically and clinically significant); the difference in Vitality was only statistically significant. In all eight SF-36 scales, scores of the present sample were clinically and statistically lower than those of the normative healthy subsample, whereas they were statistically and clinically higher than those of normative subsample which had experienced cancer, except for Rolephysical limitation. The QoL profile was associated with gender (p = 0.002), age (p = 0.001), education (p < 0.001), occupational status (p < 0.001), and the presence of other health issues (p < 0.001). Conclusion These data support the utility of rehabilitative programs which integrate both healthcare and social interventions. In addition, they encourage the monitoring of the health status of this specific population, within a broad frame which simultaneously takes into consideration health and QoL.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 86%

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Long-term quality of life profile in oncology: a comparison between cancer survivors and the general population

Annunziata

Muzzatti

Flaiban

et al. 2017

Support Care Cancer

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“…These observations confirm the results of several previously published international studies and support the need for regular psychological/psychiatric evaluation of cancer patients and cancer survivors (13,52,53,54).…”

Section: Figuresupporting

confidence: 90%

Self-reported endocrine late effects in adults treated for brain tumours, Hodgkin and non-Hodgkin lymphoma: a registry based study in Northern Germany

Gebauer

Fick

Waldmann

et al. 2015

European Journal of Endocrinology

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Objective: Due to the increasing success and survival rates in the primary treatment of malignancies derived from the CNS as well as the hematopoietic system, endocrine late effects of cancer and its therapy are of growing importance. Despite evaluation of these late effects in patients treated for cancer in childhood, the impact on adults remains largely unclear. Methods: 1035 adult patients primarily diagnosed with a CNS malignancy, a Hodgkin (HL) or non-Hodgkin lymphoma (NHL) between 1998 and 2008 were recruited via the regional epidemiological cancer registry covering w2.8 million inhabitants in the federal state of Schleswig-Holstein, Northern Germany. The prevalence of endocrine disorders and current psychosocial impairment was assessed employing several questionnaires (SF-36v1, WHO-5). Results: Fully completed questionnaires of 558 patients were available for subsequent analysis showing markedly reduced overall performance and psychological status when compared to German reference data. Thyroid disorders were reported in 16.3% of patients with 10.4% suffering from hypo-and 5.9% from hyperthyroidism. Overall, 17.6% stated to be affected by diabetes mellitus with an increased rate of 21.1% among NHL patients and 11.5% of participants were affected by osteoporosis. Conclusion: Compared to German population based studies on the prevalence of diabetes mellitus, osteoporosis and thyroid disorders the frequency of all these endocrine problems was significantly increased in CNS, HL, and NHL cancer survivors. These data confirm that not only children and adolescents but also adult cancer patients are at risk for therapy associated endocrine late effects.

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“…Research on long-term sequelae of cancer survivors indicates that survivors can reach QoL levels comparable to those of the general population but that specific detriments mainly in the psychosocial domain persist [14][15][16][17][18][19]. Our large population-based study corroborates that overall QoL in long-term cancer survivors on average is comparable to population norms but that deficits in social, role, emotional, cognitive, and physical functioning as well as in specific symptoms and financial difficulties are more prevalent in LTSs.…”

Section: Discussionsupporting

confidence: 76%

Quality of life in long-term and very long-term cancer survivors versus population controls in Germany

et al. 2017

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Background: With the increasing number and diversity of cancer survivors, studies of survivors' physical, emotional, and social health are of growing importance. While there is a growing body of literature on the quality of life (QoL) of cancer patients during the early years past diagnosis, less is known regarding QoL in long-term survivors (LTS) (5 þ years past diagnosis) and particularly in very long-term survivors (VLTS) (10 þ years past diagnosis). The objective of our study is to: (1) compare QoL of long-term cancer survivors and population norms; and (2) assess whether any deficits in QoL of survivors observed 5-10 years past diagnosis persist beyond the 10th year past diagnosis. Methods: In total 6952 long-term cancer survivors (5-16 years past diagnosis of breast, colorectal, or prostate cancer) from Germany recruited in the context of the population-based CAESAR þ study were compared with 1878 population-based controls without a history of cancer. QoL was assessed with the EORTC QLQ-C30. Differences in QoL between survivors and controls were assessed via multiple regression while controlling for age, gender, education, and case mix for survivors 5-9 years and 10 þ years past diagnosis separately. Results: Overall QoL in long-term cancer survivors was comparable to population norms but specific deficits in social, role, emotional, cognitive, and physical functioning and symptoms such as insomnia, fatigue, dyspnea, constipation, diarrhea, and financial difficulties were more prevalent in LTSs. Detriments in QoL persisted during the observation period and affected particularly cancer survivors at younger ages (<50 years). Non-significant aggravations in QoL with longer time since diagnosis were observed in very young and very old cancer survivors. Conclusions: Detriments in health-related quality of life persist over more than a decade and affect predominantly younger patients. Improvements both in early and long-term follow-up care of cancer survivors seem warranted.

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Quality of life profile in Italian long-term cancer survivors

Abstract: Our data support the usefulness of multi-disciplinary follow-ups for long-term cancer survivors and the need to pay particular attention to the psycho-emotional long-term and late-presenting sequels of cancer and its treatment.

Cited by 18 publications

References 29 publications

Long-term quality of life profile in oncology: a comparison between cancer survivors and the general population

Long-term quality of life profile in oncology: a comparison between cancer survivors and the general population

Self-reported endocrine late effects in adults treated for brain tumours, Hodgkin and non-Hodgkin lymphoma: a registry based study in Northern Germany

Quality of life in long-term and very long-term cancer survivors versus population controls in Germany

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