Self-reported endocrine late effects in adults treated for brain tumours, Hodgkin and non-Hodgkin lymphoma: a registry based study in Northern Germany

Gebauer, Judith; Fick, Eva Maria; Waldmann, Annika; Langer, Thor﻿s﻿ten; Kreitschmann-Andermahr, Ilonka; Lehnert, Hendrik; Katalinic, Alexander; Brabant, Georg

doi:10.1530/eje-15-0174

Cited by 15 publications

(11 citation statements)

References 57 publications

(75 reference statements)

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“…One previous questionnaire study investigated risk of endocrine disorders in 117 HL survivors and compared the results with the estimated frequency in the German population. Here, diabetes was reported more frequently by male HL patients . More diabetes in HL survivors were also reported after para‐aortic radiation with ≥36 Gray, explained by higher dose to the pancreatic tail …”

Section: Discussionmentioning

confidence: 56%

Increased healthcare use up to 10 years among relapse‐free Hodgkin lymphoma survivors in the era of intensified chemotherapy and limited radiotherapy

et al. 2017

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With today's excellent cure rates for Hodgkin lymphoma (HL), the number of long-term survivors is increasing. This study aims to provide a global assessment of late adverse effects for working-age HL survivors treated with contemporary protocols (combination chemotherapy and limited radiotherapy). From Swedish nationwide registers we identified 1017 HL survivors diagnosed in 2000-2009, aged 18-60 years (median 32) and surviving at least one year post-diagnosis, and 4031 age-, sex-, and calendar-year-matched population comparators. Incidence rate ratios (IRR) and 95% confidence intervals (95%CI) for outpatient visits and inpatient bed-days after the first year up to 14 years post-diagnosis (through 2013) were estimated across treatment subgroups, considering relapse-free time and using negative binomial regression. Scheduled outpatient visits for HL were excluded. The rate of outpatient visits was nearly double (IRR = 1.8, 95%CI: 1.6-2.0) that among comparators and higher rates persisted up to 10 years post-diagnosis. The rate of inpatient bed-days among relapse-free survivors was more than three-fold (IRR = 3.6, 95%CI: 2.7-4.7) that of comparators and the increase persisted up to four years post-diagnosis. Patients requiring 6-8 chemotherapy courses had higher rates of outpatient visits (IRR = 1.4, 95%CI: 1.1-1.7) and bed-days (IRR = 4.7, 95%CI: 2.9-7.8) than patients treated with 2-4 courses + radiotherapy. Previously seldom reported reasons for the excess healthcare use included chest pain, keratitis, asthma, diabetes mellitus, and depression. Contemporary treatment, chemotherapy in particular, was associated with excess healthcare use among HL survivors during the first decade postdiagnosis. The reasons for healthcare visits reflected a wide range of disorders, indicating the need of broad individualized care in addition to specific screening programs.

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Section: Discussionmentioning

confidence: 56%

Increased healthcare use up to 10 years among relapse‐free Hodgkin lymphoma survivors in the era of intensified chemotherapy and limited radiotherapy

et al. 2017

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“…Questionnaires included instruments covering subjective sleep quality and HRQOL. More details regarding the study and questionnaires have been described elsewhere [ 22 ].…”

Section: Methodsmentioning

confidence: 99%

“…diagnosis, stage of cancer, therapy-associated endocrine late effects), physical complaints (e.g. pain, nausea), psychological and environmental factors as well as medications and their side effects may also be discussed [ 8 , 17 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Sleep quality and health-related quality of life among long-term survivors of (non-) Hodgkin lymphoma in Germany

Hammersen¹,

Lewin²,

Gebauer

et al. 2017

PLoS ONE

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This study investigated sleep quality and health-related quality of life (HRQOL) among long-term survivors of Hodgkin (HL) and non-Hodgkin lymphoma (NHL). The aim was to explore the impact of personal and health-related factors on sleep quality as well as associations between sleep quality and HRQOL. For the postal survey, participants with a minimum age of 18 years initially treated between 1998 and 2008 were recruited via the population-based cancer registry in Schleswig-Holstein, Northern Germany. Questionnaires included amongst others the Pittsburg Sleep Quality Index (PSQI) and the 36-Item Short Form Health Survey (SF-36v1). Descriptive and comparative statistics were performed. Additionally, a regression analysis was conducted to identify predictors of sleep quality. In total, we recruited 515 participants (398 NHL, 117 HL) with a mean age of 63.1 years. Approximately half of the survivors were classified as good sleepers. HRQOL scores differed between good and poor sleepers with lower scores in poor sleepers. In a prediction model, self-reported depression, exhaustion, higher age, inability to work, endocrinological disorders and female gender classified as predictors of sleep quality. This study highlights the impact of sleep quality on HRQOL in long-term survivors of NHL and HL. Thus, sleep quality should be routinely assessed during follow-up of cancer survivors with special attention to patients with potential risk factors.

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“…Due to advancements in therapy, the overall 5-year survival rate for those diagnosed with lymphoma is greater than 85% [ 3 , 4 ]. However, survivors experience severe and often life-long health consequences as a result of their treatment, including an elevated risk of second primary cancers and other serious chronic conditions [ 5 , 6 , 7 , 8 , 9 ]. Because of these often devastating late effects, the identification of risk factors for the prevention of childhood lymphoma is critical [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Residential Radon Exposure and Incidence of Childhood Lymphoma in Texas, 1995–2011

Peckham

Scheurer

Danysh

et al. 2015

IJERPH

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There is warranted interest in assessing the association between residential radon exposure and the risk of childhood cancer. We sought to evaluate the association between residential radon exposure and the incidence of childhood lymphoma in Texas. The Texas Cancer Registry (n = 2147) provided case information for the period 1995–2011. Denominator data were obtained from the United States Census. Regional arithmetic mean radon concentrations were obtained from the Texas Indoor Radon Survey and linked to residence at diagnosis. Exposure was assessed categorically: ≤25th percentile (reference), >25th to ≤50th percentile, >50th to ≤75th percentile, and >75th percentile. Negative binomial regression generated adjusted incidence rate ratios (aIRR) and 95% confidence intervals (CI). We evaluated lymphoma overall and by subtype: Hodgkin (HL; n = 1248), Non-Hodgkin excluding Burkitt (non-BL NHL; n = 658), Burkitt (BL; n = 241), and Diffuse Large B-cell (DLBCL; n = 315). There was no evidence that residential radon exposure was positively associated with lymphoma overall, HL, or BL. Areas with radon concentrations >75th percentile had a marginal increase in DLBCL incidence (aIRR = 1.73, 95% CI: 1.03–2.91). In one of the largest studies of residential radon exposure and the incidence of childhood lymphoma, we found little evidence to suggest a positive or negative association; an observation consistent with previous studies.

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Self-reported endocrine late effects in adults treated for brain tumours, Hodgkin and non-Hodgkin lymphoma: a registry based study in Northern Germany

Cited by 15 publications

References 57 publications

Increased healthcare use up to 10 years among relapse‐free Hodgkin lymphoma survivors in the era of intensified chemotherapy and limited radiotherapy

Increased healthcare use up to 10 years among relapse‐free Hodgkin lymphoma survivors in the era of intensified chemotherapy and limited radiotherapy

Sleep quality and health-related quality of life among long-term survivors of (non-) Hodgkin lymphoma in Germany

Residential Radon Exposure and Incidence of Childhood Lymphoma in Texas, 1995–2011

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