Quality of life predicts rehabilitation prognosis in Parkinson's disease patients

Meng, Detao; Jin, Zhaohui; Chen, Keke; Yu, Xin; Wang, Yixuan; Du, Wei; Wei, Jingran; Xi, Jianing; Fang, Boyan

doi:10.1002/brb3.2579

Cited by 2 publications

(1 citation statement)

References 52 publications

(90 reference statements)

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“…PASS11 software was used to calculate the sample size. According to the previous literature [ 65 , 66 ], which includes the results of PDQ-39 in individuals with Parkinson’s disease, and in combination with this experiment, we designed a ratio of 1:1 between the tACS + MIRT group and Sham-tACS + MIRT group. The statistical power was set at 0.9, with a significance level (α) of 0.05.…”

Section: Interventionsmentioning

confidence: 99%

Transcranial alternating current stimulation improves quality of life in Parkinson’s disease: study protocol for a randomized, double-blind, controlled trial

Zhang,

Hou,

Jin

et al. 2024

Trials

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Background The neural cells in the brains of patients with Parkinson’s disease (PWP) display aberrant synchronized oscillatory activity within the beta frequency range. Additionally, enhanced gamma oscillations may serve as a compensatory mechanism for motor inhibition mediated by beta activity and also reinstate plasticity in the primary motor cortex affected by Parkinson’s disease. Transcranial alternating current stimulation (tACS) can synchronize endogenous oscillations with exogenous rhythms, thereby modulating cortical activity. The objective of this study is to investigate whether the addition of tACS to multidisciplinary intensive rehabilitation treatment (MIRT) can improve symptoms of PWP so as to enhance the quality of life in individuals with Parkinson’s disease based on the central-peripheral-central theory. Methods The present study was a randomized, double-blind trial that enrolled 60 individuals with Parkinson’s disease aged between 45 and 70 years, who had Hoehn-Yahr scale scores ranging from 1 to 3. Participants were randomly assigned in a 1:1 ratio to either the tACS + MIRT group or the sham-tACS + MIRT group. The trial consisted of a two-week double-blind treatment period followed by a 24-week follow-up period, resulting in a total duration of twenty-six weeks. The primary outcome measured the change in PDQ-39 scores from baseline (T0) to 4 weeks (T2), 12 weeks (T3), and 24 weeks (T4) after completion of the intervention. The secondary outcome assessed changes in MDS-UPDRS III scores at T0, the end of intervention (T1), T2, T3, and T4. Additional clinical assessments and mechanistic studies were conducted as tertiary outcomes. Discussion The objective of this study is to demonstrate that tACS can enhance overall functionality and improve quality of life in PWP, based on the framework of MIRT. Additionally, it seeks to establish a potential correlation between these therapeutic effects and neuroplasticity alterations in relevant brain regions. The efficacy of tACS will be assessed during the follow-up period in order to optimize neuroplasticity and enhance its potential impact on rehabilitation efficiency for PWP. Trial registration Chinese Clinical Trial Registry ChiCTR2300071969. Registered on 30 May 2023.

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Section: Interventionsmentioning

confidence: 99%

Transcranial alternating current stimulation improves quality of life in Parkinson’s disease: study protocol for a randomized, double-blind, controlled trial

Zhang,

Hou,

Jin

et al. 2024

Trials

Self Cite

View full text Add to dashboard Cite

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Quality of life predicts rehabilitation prognosis in Parkinson's disease patients

et al. 2022

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Background: Rehabilitation has been reported to improve the quality of life (QoL) of patients with Parkinson's disease (PD). Nevertheless, not all patients are satisfied with rehabilitation outcomes and could achieve a significant improvement in QoL.Objective: To detect possible predictors of QoL improvement in patients with PD after rehabilitation.Methods: A total of 86 PD patients were included and followed up for 3 months with a 39-item Parkinson's Disease Questionnaire summary index (PDQ-39 SI) as the primary endpoint. All patients received 2 weeks of multidisciplinary intensive rehabilitation treatment (MIRT). Changes in patients' QoL were assessed using the PDQ-39 at baseline and at the 3-month follow-up. The reliable change index (RCI) was adapted to determine the individual QoL outcome. The predictors of QoL outcome were detected using logistic regression analysis.Results: After a 3-month follow-up, PDQ-39 SI decreased significantly from 22.95 ± 9.75 to 18.73 ± 10.32 (P < 0.001). Scores for QoL improved (RCI>10.9) after rehabilitation for 18.6% of the patients, and 74.4% of patients reported an unchanged QoL (−10.9≤RCI≤10.9), while 7.0% of patients reported a worsening of QoL (RCI<−10.9).

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Quality of life predicts rehabilitation prognosis in Parkinson's disease patients

Cited by 2 publications

References 52 publications

Transcranial alternating current stimulation improves quality of life in Parkinson’s disease: study protocol for a randomized, double-blind, controlled trial

Transcranial alternating current stimulation improves quality of life in Parkinson’s disease: study protocol for a randomized, double-blind, controlled trial

Quality of life predicts rehabilitation prognosis in Parkinson's disease patients

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