Quality of Life of Patients with Oral Cavity Cancer

Dzebo, Senada; Mahmutović, Jasmina; Erkočević, Hasiba

doi:10.5455/msm.2017.29.30-34

Cited by 20 publications

(19 citation statements)

References 14 publications

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“…Several studies have described the post-treatment evaluation of HR-QOL for OSCC patients and assessed factors associated with improvements in prognosis. These studies reinforce the hypothesis that patients who survived surgery may effectively improve and even recover their HR-QOL levels, at least to pre-operative ratings [11,14,19,23-24]. The improvement of certain QOL domain scores with increasing follow up duration, as seen in our study, points to the fact that cancer patients in the initial years of follow up experience psychological stress and post-treatment effects of different treatments they receive.…”

Section: Discussionsupporting

confidence: 88%

“…The UW-QOL questionnaire has already been validated by studies comparing the results of its application with those obtained from other well-established questionnaires in the same field of study. Besides effectively assessing QOL, the UW-QOL was well accepted by respondents and appraised as a reliable, practical, and low-cost instrument for surveying the functional status of patients with head and neck cancer [ 11 ]. However, the feasibility of its use in different languages still demands further research.…”

Section: Discussionmentioning

confidence: 99%

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Assessment of Factors Affecting Quality of Life in Oral Squamous Cell Carcinoma Patients Using University of Washington Quality of Life Questionnaire

Abbas

Tariq

Raheem

et al. 2019

Cureus

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IntroductionPost-treatment Quality of Life (QOL) is considered an important outcome in cancer patients. A number of questionnaire tools have been designed for its assessment. University of Washington Quality of Life (UW QOL) questionnaire version four is a reliable tool for assessment of post-treatment QOL in oral squamous cell carcinoma (OSCC) patients. Our aim was to identify the post-treatment problems faced by OSCC patients and to assess the impact of clinical factors affecting post-treatment QOL by using UW QOL (version four) questionnaire.MethodsThe study was conducted on 59 patients with OSCC who were treated with curative intent at Patel Hospital, Karachi from August 2015 to September 2015. Patients were asked to fill the UW QOL questionnaire (version four) on their follow-up visit.ResultsOverall mean composite QOL score was 66.59 ± 16.98. Chewing and saliva (dryness of mouth) had the lowest scores (38.98 ± 37.2 and 56.78 ± 41.4, respectively) among all domains while pain and anxiety had the highest scores (80.93 ± 20.4 and 79.66 ± 29.8, respectively). Patients having tumors of the tongue, late stage (III and IV) tumors, and restricted mouth opening had significantly lower mean composite QOL scores. Patients with tongue tumors revealed significantly lower scores for pain, swallowing, mood, and anxiety. Patients with late-stage tumors showed significantly lower scores for chewing, swallowing, taste, saliva, appearance, anxiety, and recreation. Patients with restricted mouth opening had significantly lower scores for pain, speech, appearance, recreation, and anxiety domains.ConclusionDifferent clinical features have different impacts on QOL in terms of problems faced by the patients. Features having a significant effect should be identified, and measures focused on most relevant problems should be employed in order to improve the post-treatment QOL.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Assessment of Factors Affecting Quality of Life in Oral Squamous Cell Carcinoma Patients Using University of Washington Quality of Life Questionnaire

Abbas

Tariq

Raheem

et al. 2019

Cureus

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“…Nearly 90% of these tumors are diagnosed as squamous cell carcinoma. In most of the cases, the malignant lesions are detected in an advanced stage (stages III and IV) (17-19) in the oral cavity, the larynx and the pharynx (18,20). These findings were also observed in the sample investigated in the present study.…”

Section: Discussionmentioning

confidence: 99%

“…Measuring the quality of life of patients in relation to their health condition became more important over time (18). This procedure may be used as an indicator of the effectiveness of the treatment and the specific areas in which the patient needs more attention (30).…”

Section: Discussionmentioning

confidence: 99%

Oral health related quality of life and determinant factors in patients with head and neck cancer

Melo¹,

Sousa²,

Bernardino³

et al. 2019

Med Oral

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Background The present study aimed to measure the impact of oral health on the quality of life of patients with head and neck cancer. Material and Methods A cross-sectional study was conducted with 130 patients diagnosed with head and neck cancer at two medical centers. Participants answered a sociodemographic questionnaire and the Oral Health Impact Profile - 14 (OHIP-14). Clinical aspects, cancer staging, and treatment approach were also investigated. Mann-Whitney and Kruskal-Wallis non-parametric tests were used for statistical analysis, followed by Poisson regression analysis (with robust error variance), to associate the OHIP-14 scores with independent variables. Results The OHIP-14 presented good internal consistency (Cronbach’s Alpha = 0.861). The mean score obtained was 19.52 (±11.79). Physical pain (3.70±2.44), physical disability (3.26±2.62) and functional limitation (3.24±2.45) were ranked as the main factors affecting the quality of life. Patients non-Caucasians (PR = 1.30; IC 95% = 1.07-1.58; p = 0.009), widowers (PR = 1.36; IC 95% = 1.13-1.64; p = 0.001), diagnosed with squamous cell carcinoma (PR = 1.28; IC 95% = 1.05-1.58; p = 0.017) and with temporomandibular pain (PR = 1.31; IC 95% = 1.08-1.60; p = 0.007) were more likely to exhibit lower rates of quality of life. Conclusions The results showed a high impact of the oral health in the quality of life of patients with head and neck cancer was observed. Sociodemographic and clinical characteristics can exert influence on the quality of life of patients with head and neck cancer. Key words: Quality of life, malignant neoplasms, head and neck neoplasms, oral health, epidemiology.

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“…Currently, the most effective treatment of TSCC is surgical resection. However, excessive surgical excision often affects oral function and postoperative quality of life in patients with TSCC ( 3 ). Following adjuvant treatment radiotherapy, chemotherapy or immunotherapy, the survival rate of patients with TSCC has markedly improved, but it remains unsatisfactory.…”

Section: Introductionmentioning

confidence: 99%

Isobavachalcone inhibits the proliferation and invasion of tongue squamous cell carcinoma cells

Shi¹,

Wu²,

Huo³

et al. 2017

Oncology Letters

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Isobavachalcone (2′,4′,4-trihydroxy-3′-[3′-methylbut-3′-ethyl] chalcone or IBC) exhibits anticancer activities in a number of types of cancer cell. However, its role in tongue squamous cell carcinoma (TSCC) cells remains unclear. The aim of the present study was to investigate the biological effect of IBC in TSCC Tca8113 cells. The function of IBC on Tca8113 cell apoptosis and apoptosis-associated signaling pathways was determined using an MTT assay, morphological staining, annexin V-propidium iodide (PI) staining and Western blot analysis. The effects of IBC on Tca8113 cell migration, invasion and relative protein expression were confirmed using wound healing analysis, Transwell invasion analysis and Western blot analysis, respectively. The results of the MTT assay and annexin V-PI staining indicated that IBC is able to significantly inhibit proliferation and induce apoptosis of Tca8113 cells in vitro. IBC treatment resulted in typical apoptotic morphology of nuclear fragmentation and apoptotic bodies in Tca8113 cells. Western blot analysis further demonstrated that IBC caused downregulation of the expression of B-cell lymphoma 2 (Bcl-2) protein, upregulation of the expression of Bcl-2-associated X protein (Bax), activation of caspases, and dephosphorylation of protein kinase B (Akt) and extracellular-signal-regulated kinase (ERK) proteins in a concentration- and time-dependent manner. The results of the present study suggest that IBC induces apoptosis in Tca8113 cells and that the induction may be associated with the activation of Bcl-2, Bax and caspase-3, and the inactivation of Akt and ERK. Furthermore, IBC inhibited migration and invasion of Tca8113 cells in vitro by downregulating matrix metalloproteinase (MMP)-2 and MMP-9 protein expression. The results of the present study indicate that IBC may be a potential anticancer drug for the treatment of TSCC.

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Quality of Life of Patients with Oral Cavity Cancer

Cited by 20 publications

References 14 publications

Assessment of Factors Affecting Quality of Life in Oral Squamous Cell Carcinoma Patients Using University of Washington Quality of Life Questionnaire

Assessment of Factors Affecting Quality of Life in Oral Squamous Cell Carcinoma Patients Using University of Washington Quality of Life Questionnaire

Oral health related quality of life and determinant factors in patients with head and neck cancer

Isobavachalcone inhibits the proliferation and invasion of tongue squamous cell carcinoma cells

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