Quality of life in patients with pemphigus receiving adjuvant therapy

Abstract

We found no significant differences in QOL impairment between the treatment subgroups; however, we observed a strong association between psychiatric morbidity and poorer QOL within each of the treatment groups. This should be of concern for dermatologists, as psychiatric morbidity is associated with poor treatment adherence and dissatisfaction with care.

Health-related quality of life and its determinants in pemphigus: a systematic review and meta-analysis

“…The meta‐analysis indicated similar mean scores in the symptoms (35·8, 95% CI 32·7–38·9) and emotions (36·5, 95% CI 33·8–39·2) domains of Skindex‐29, whereas they were slightly lower for social functioning (32·8, 95% CI 29·9–35·6) (Fig. c) …”

“…Four types of dermatology‐ or oral‐disease‐specific tools were applied: DLQI, Skindex‐29, Skindex‐17 and Chronic Oral Mucosal Diseases Questionnaire. The most frequently used measures were SF‐36 (eight of 16), DLQI (five of 16) and Skindex‐29 (four of 16) …”

Adjuvant rituximab therapy in pemphigus: a single-center experience of 18 cases

“…These data from the German Registry of Autoimmune Diseases was updated recently in 36 PV patients showing a 94% partial or complete initial responsiveness to rituximab (15). While Faurschou and Gniadecki (22) used a second course of rituximab treatment 6 months after the first course, inducing some cases of complete remission, this would suggest that multiple courses of rituximab can be efficacious in partial (as well as non-) responders without serious morbidity and with an acceptable reported quality of life (23).…”

Autoimmune blistering diseases in females: a review

“…Like many other skin diseases, the QOL of females with AIBD was found to be affected more than the QOL of males in several studies to date (Paradisi et al, 2009, Paradisi et al, 2012, Sampogna et al, 2006). The significant impacts of AIBDs on QOL are due to factors such as time spent on treatment, financial burden, social misconceptions, physical discomfit and limitations, and poor mental health (Chee and Murrell, 2011, Sebaratnam et al, 2012).…”