Quality of Life in Iranian Chemical Warfare Veteran's

Ebadi, Abbas; Moradian, Tayeb; Mollahadi, Mohsen; Saeed, Yaser; Refahi, A A

doi:10.5812/ircmj.5323

Cited by 9 publications

(1 citation statement)

References 17 publications

(21 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Scores for each subtitle range from 0 to 100, which 100 representing the best Health-Related QOL (HRQOL) and 0 representing the worst. The scores of the questionnaire were analyzed in three low (0 - 33), moderate (34 - 66) and high levels (66 - 100) ( 16 , 17 ).…”

Section: Methodsmentioning

confidence: 99%

Quality of Life and Related Factors Among People With Spinal Cord Injuries in Tehran, Iran

et al. 2015

View full text Add to dashboard Cite

Background:Spinal Cord Injury (SCI) is one of the biggest health problems. Disabilities resulting from injuries such as spinal disability requires special attention because of their potential reduced to cause adverse effects in different systems of the body. Today, improving the Quality of Life (QOL) in patients with SCIs is an important goal of treatment.Objectives:The purpose of this study was to determine the QOL and related factors among people with SCIs.Patients and Methods:In this cross-sectional descriptive study, 106 patients with SCI were selected through sampling based on census. Data were collected using a demographic questionnaire and a Short-Form 36 (SF-36) health survey questionnaire for measuring the QOL among patients. Data were analyzed using SPSS 14 software and descriptive and inferential statistics. P < 0.05 was considered statistically significant.Results:The mean QOL in these patients was 37.1 ± 1.7 years (21 - 65 years) and mean disease duration was 7.3±6 years. The most common injury was paraplegia. Most of the patients have moderate QOL (54.7 %). The results showed a significant relationship between QOL and marital status and employment status (P < 0.05). Also, results showed a significant relationship between QOL and education levels (P = 0.002), age (P = 0.001), and duration of illness (P = 0.001).The highest and lowest scores were 64 ± 7.1 and 36 ± 5.3 for understanding General Health (GH) and role physical, respectively.Conclusions:The results show that patients with SCI have a moderate health-related QOL Determining the QOL is needed to focus on the strengths and weaknesses of patients with spinal cord injuries. Planning principles is recommended in order to reform the disability.

show abstract

Section: Methodsmentioning

confidence: 99%

Quality of Life and Related Factors Among People With Spinal Cord Injuries in Tehran, Iran

et al. 2015

View full text Add to dashboard Cite

show abstract

An evidence-based review of the genotoxic and reproductive effects of sulfur mustard

et al. 2016

View full text Add to dashboard Cite

Sulfur mustard (SM) is a chemical warfare agent which is cytotoxic in nature, and at the molecular level, SM acts as DNA alkylating agent leading to genotoxic and reproductive effects. Mostly, the exposed areas of the body are the main targets for SM; however, it also adversely affects various tissues of the body and ultimately exhibits long-term complications including genotoxic and reproductive effects, even in the next generations. The effect of SM on reproductive system is the reason behind male infertility. The chronic genotoxic and reproductive complications of SM have been observed in the next generation, such as reproductive hormones disturbances, testicular atrophy, deficiency of sperm cells, retarded growth of sperm and male infertility. SM exerts toxic effects through various mechanisms causing reproductive dysfunction. The key mechanisms include DNA alkylation, production of reactive oxygen species (ROS) and nicotinamide adenine dinucleotide (NAD) depletion. However, the exact molecular mechanism of such long-term effects of SM is still unclear. In general, DNA damage, cell death and defects in the cell membrane are frequently observed in SM-exposed individuals. SM can activate various cellular and molecular mechanisms related to oxidative stress (OS) and inflammatory responses throughout the reproductive system, which can cause decreased spermatogenesis and impaired sperm quality via damage to tissue function and structure. Moreover, the toxic effects of SM on the reproductive system as well as the occurrence of male infertility among exposed war troopers in the late exposure phase is still uncertain. The chronic effects of SM exposure in parents can cause congenital defects in their children. In this review, we aimed to investigate chronic genotoxic and reproductive effects of SM and their molecular mechanisms in the next generations.

show abstract

Th17/Treg immunoregulation and implications in treatment of sulfur mustard gas-induced lung diseases

Iman

Rezaei

Jamalkandi

et al. 2017

Expert Review of Clinical Immunology

View full text Add to dashboard Cite

Sulfur mustard (SM) is an extremely toxic gas used in chemical warfare to cause massive lung injury and death. Victims exposed to SM gas acutely present with inhalational lung injury, but among those who survive, some develop obstructive airway diseases referred to as SM-lung syndrome. Pathophysiologically, SM-lung shares many characteristics with smoking-induced chronic obstructive pulmonary disease (COPD), including airway remodeling, goblet cell metaplasia, and obstructive ventilation defect. Some of the hallmarks of COPD pathogenesis, which include dysregulated lung inflammation, neutrophilia, recruitment of interleukin 17A (IL -17A) expressing CD4T cells (Th17), and the paucity of lung regulatory T cells (Tregs), have also been described in SM-lung. Areas covered: A literature search was performed using the MEDLINE, EMBASE, and Web of Science databases inclusive of all literature prior to and including May 2017. Expert commentary: Here we review some of the recent findings that suggest a role for Th17 cell-mediated inflammatory changes associated with pulmonary complications in SM-lung and suggest new therapeutic approaches that could potentially alter disease progression with immune modulating biologics that can restore the lung Th17/Treg balance.

show abstract

Quality of Life in Iranian Chemical Warfare Veteran's

Cited by 9 publications

References 17 publications

Quality of Life and Related Factors Among People With Spinal Cord Injuries in Tehran, Iran

Quality of Life and Related Factors Among People With Spinal Cord Injuries in Tehran, Iran

An evidence-based review of the genotoxic and reproductive effects of sulfur mustard

Th17/Treg immunoregulation and implications in treatment of sulfur mustard gas-induced lung diseases

Contact Info

Product

Resources

About