Quality of life improves after strabismus surgery in patients with Graves' orbitopathy

Abstract

Objective: To evaluate the influence of strabismus surgery on quality of life (QoL) in Graves' orbitopathy (GO) patients. Design: Prospective study of case series. Methods: Consecutive GO-patients who were scheduled for their first strabismus surgery were included in the study. The patients completed the GO-QoL questionnaire within 3 months before the surgery and 2-4 months after the surgery. A complete orthoptic examination, including the field of binocular single vision (BSV), was performed. Clinically relevant response (CRR) in the QoL was also evaluated. Results: In this study, 28 patients were included. The GO-QoL score for visual functioning was 46.3G24.2 before surgery and 65.7G30.5 after surgery (PZ0.009). The GO-QoL score for appearance changed from 60.6G25.9 to 69.5G24.2 (PZ0.005). After surgery, the field of BSV increased from 24.3G34.8 to 68.5G36.0 points (PZ0.000). A weak correlation was found between the field of BSV and the visual functioning score after surgery (rZ0.417; PZ0.034). CRR was found in 20 (71%) patients. Those with a CRR showed a larger field of BSV (PZ0.002) and better GO-QoL scores (PZ0.008). Conclusions: GO-QoL score increases significantly for both visual functioning and appearance after the first strabismus surgery in GO-patients, showing the highest improvement for the visual functioning questions. Both the GO-QoL and field of BSV outcomes correlate well with the CRR.

Objective and subjective outcomes of strabismus surgery in Graves' orbitopathy: a prospective multicentre study

“…The difference can be explained by the contribution of the second procedure. Several reasons for the high discrepancy between the QoL scores are explained in our previous study (Jellema et al 2014). Moreover, both changes are much higher than the aforementioned six points of minimal clinically important difference found in the study of Terwee et al (2001).…”

“…The field of BSV and the quality of life (QoL) are among recently published criteria defining successful treatment (Jellema et al 2015), in which the patient reported outcome is complementary to the clinically measured outcome (Sprangers 2010). The GO-QoL is used in a pilot study evaluating the impact of a first strabismus surgery (Jellema et al 2014). The GO-QoL is used in a pilot study evaluating the impact of a first strabismus surgery (Jellema et al 2014).…”

THERAPY OF ENDOCRINE DISEASE: Endocrine dilemma: management of Graves’ orbitopathy

“…No differences were found in the QoL in patients previously submitted to orbital decompression compared with those who only underwent squint surgery (144). Medical treatment yields more conflicting results.…”

Update on thyroid-associated Ophthalmopathy with a special emphasis on the ocular surface

“…GO-QoL may be useful in assessing surgical outcomes [93]. At least one study demonstrated improved GO-QoL score following strabismus surgery in TAO [94]. …”