Quality of life for children with fecal incontinence after surgically corrected anorectal malformation

Bai, Yunlong; Yuan, Zhengwei; Wang, Weilin; Zhao, Yaru; Wang, Huizhen; Wang, Wei

doi:10.1016/s0022-3468(00)90215-x

Cited by 134 publications

(99 citation statements)

References 6 publications

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“…The incidence is relatively high and can require extensive surgery to provide a tolerable quality of life. Even with surgical intervention the outlook for those with more serious defects is poor and for those who respond well to surgery there is often a long-term follow up required, in addition to psychological damage (Bai et al, 2000, Hartman et al, 2004. Our studies provide new insights into the molecular bases of ARMs, and suggest a robust model system for future analysis of the genetic and teratogenic contributors to ARMs.…”

Section: The Zebrafish As a Model For Armsmentioning

confidence: 86%

Hedgehog signalling is required for cloacal development in the zebrafish embryo

Parkin¹,

Allen²,

Ingham³

2009

Int. J. Dev. Biol.

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The Hedgehog (Hh) family of signalling molecules is essential for a wide range of developmental processes. Mammalian studies have implicated the Hedgehog pathway in the aetiology of anorectal malformations (ARMs), relatively common congenital anomalies caused by failures in the development of the cloaca. In this study we demonstrate that Hh signalling is absolutely required for the formation of the zebrafish cloaca and that the severity of the posterior gut abnormalities induced by a reduction in Hh activity is dependent on the levels of Hh signal transduction. The complete loss of all Hh activity results in the most severe defects and the critical period for Hh activity is between 34 and 74 hours post fertilisation. Using a range of mutant genotypes that cause notochord and floorplate abnormalities, we show that the source of the Hh signals required for posterior gut formation is the endoderm and not the notochord, as previously postulated in mammalian models of ARMs. We show that Adriamycin, a drug known to cause ARMs in rat, but not chick embryos, has no effect on the development of the zebrafish gastrointestinal tract. These studies establish the zebrafish as a model for ARMs, and for the elucidation of other pathways involved in hindgut developmental processes.

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Section: The Zebrafish As a Model For Armsmentioning

confidence: 86%

Hedgehog signalling is required for cloacal development in the zebrafish embryo

Parkin¹,

Allen²,

Ingham³

2009

Int. J. Dev. Biol.

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“…Psychosoziale Beeinträchtigungen entstehen im Bereich eines schambesetzten Körper-und Selbstkonzepts, das zu einer global reduzierten gesundheitsbezogenenen Lebensqualität generalisieren kann (vgl. Diseth et al, 1998;Hassink, 1994;Ludman, 1994;Bai, 2000). Viele Patienten benöti-gen eine langzeitige, auf Kontinuität angelegte und interdisziplinäre Behandlung im Zusammenwirken mit Unterstützung aus der Selbsthilfe und dem privaten familiären und sozialen Umfeld (Jenetzky u. Schwarzer, 2008).…”

Section: Interferenz Von Krankheitsbild Und Entwicklungsaufgabenunclassified

“…In einer chinesischen Studie wurden auf der Basis der Child Behavior Checklist (CBCL) für die Gesamtgruppe anorektal fehlgebildeter Kinder eine Prävalenz von 18,3 % komorbider Verhaltensstörungen identifiziert (Bai et al, 2000). Die Häufig-keiten divergierten extrem für die Subgruppe der Kinder mit Stuhlinkontinez (66,7 %) versus ohne Stuhlinkontinenz (8,6 %).…”

Section: Psychische Adaptation Lebensqualität Und Komorbide Psychiscunclassified

Adaptation und Lebensqualität bei anorektaler Malformation: Empirische Befunde, theoretisches Modell, psychodiagnostische Erfassung und verhaltensmedizinische Intervention

Noeker

2010

Praxis der Kinderpsychologie und Kinderpsychiatrie

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NutzungsbedingungenAnorectal malformations are inborn developmental defects that are associated with multiple functional Impairments (especially incontinence) and psychosocial burden with a major impact on body schema and self-esteem. Child psychology and psychiatry research begin to identify disorder-dependent and -independent risk and protective factors that predict the outcome of psychological adaptation and quality of life. The present paper analyses the interference of structural and functional disease parameters with the achievement of regular developmental tasks, presents a hypothetical conceptual framework concerning the development of psychological adaptation and quality of life in ARM, integrates findings from empirical research with the framework presented and outlines strategies of psychological support from a cognitive-behavioural perspective within a multidisciplinary treatment approach to enhance medical, functional, and psychosocial quality of life.

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“…6 For most, this means being able to actively participate in their social environment without significant limitations from bowel function, for which fecal continence is a major determinant. [7][8][9] Posterior sagittal anorectoplasty (PSARP), first introduced by De Vries and Peña and followed later by its limited modification anterior sagittal anorectoplasty (ASARP), represents the basis of the modern surgical approach to ARMs with termination of the anal canal outside the voluntary sphincter complex. 10,11 The outcome for patients with ARM is related to the severity of the anomaly.…”

Section: Introductionmentioning

confidence: 99%

Assessment of post-surgical functional outcome in children with anorectal malformation

Patel¹,

Ma²,

Sharma³

et al. 2018

Int Surg J

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Background: Anorectal malformations (ARMs) comprise a spectrum of congenital anomalies that continue to present a challenge for paediatric surgeons. Advances in modern surgical techniques and neonatal care have greatly improved survival among ARM patients over the last decades, and early mortality is now unusual in the absence of fatal associated cardiac or chromosomal defects. The aim of this study is to measure the functional outcome of ARM by most recent krickenburg classification.Methods: The present longitudinal study was conducted in Department of paediatric surgery, Dr. BRAM hospital, Raipur, Chhattisgarh during study period February 2016 to September 2017. Those patients who had completed their all stages of surgery for anorectal malformation at-least 6 months back and arriving at outpatient department of paediatric surgery were included.Results: Maximum number of patients were in age group of 3 to 5 years (77.8%) and minimum were 9 to 11 years (3.7%). A 50.6% male and 49.4% female child were included in the study. Maximum number of patients had vestibular fistula (38.27% followed by perineal fistula (24.69%), rectobulbar (18.51%) then rectovaginal (7.4%) and rectoprostatic (7.4%). Minimum patients had pouch colon (2.4%) and cloaca (1.09%). Voluntary bowel movement was present in 50% of rectoprostatic and 66.6% of rectovaginal fistula. Eighty percentage rectobulbar and 83.87% vestibular fistula had voluntary bowel movement. Cloaca and Pouch colon had no voluntary bowel movement. In recto-vaginal fistula 66.6% had soiling, of which 50% had grade 1 and 16.6% had grade 2 soiling. In recto-bulbar fistula 40% cases had soiling, out of which 20% had grade1 and 20% had grade 2. In recto-vaginal fistula cases 33 % had constipation, of which 16.5% had grade 1 and 16.6 % had grade 2. In recto-prostatic fistula 16% had constipation which was grade1.Conclusions: In this study, author showed that functional outcomes comparable to matched peers are achieved in the majority of low ARMs after minimally invasive, individualized perineal procedures and regular surgical follow-up. In high type of ARM soiling is the prominent feature while in intermediate ARM constipation is more common.

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Quality of life for children with fecal incontinence after surgically corrected anorectal malformation

Cited by 134 publications

References 6 publications

Hedgehog signalling is required for cloacal development in the zebrafish embryo

Hedgehog signalling is required for cloacal development in the zebrafish embryo

Adaptation und Lebensqualität bei anorektaler Malformation: Empirische Befunde, theoretisches Modell, psychodiagnostische Erfassung und verhaltensmedizinische Intervention

Assessment of post-surgical functional outcome in children with anorectal malformation

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