Quality of Life, Depression, Anxiety and Coping Strategies after Heart Transplantation

Trevizan, Fulvio Bergamo; Miyazaki, Maria Cristina de Oliveira Santos; Silva, Yasmin Lima Witzel; Roque, Christiane Maia Waetman

doi:10.21470/1678-9741-2017-0029

Cited by 24 publications

(45 citation statements)

References 15 publications

(33 reference statements)

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“…Depression is a disorder that induces severe social and economic problems in the modern society. Its pathogenesis has been well documented in the previous studies [1] and has been confirmed to be associated with repeated exposure to harmful stress, which may include a variety of social and un-social stimuli, such as poor parental care [2], drug addiction [3], and heart surgery [4]. The presently available antidepressants in clinic, such as the selective monoamine oxidase inhibitors and the serotonin reuptake inhibitors, ameliorate depressive symptoms mainly through rectifying the monoamine dysfunction in the brain [5][6][7].…”

Section: Introductionmentioning

confidence: 94%

Lipopolysaccharide-Induced Depression-Like Behaviors Is Ameliorated by Sodium Butyrate via Inhibiting Neuroinflammation and Oxido-Nitrosative Stress

Qiu

Liu

et al. 2020

Pharmacology

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Depression is a common disease that afflicts one in 6 people. Numerous hypotheses have been raised in the past decades, but the exact mechanism for depression onset remains obscure. Recently, the neuroinflammatory response and oxidative stress are being attracted more and more attention due to their roles in depression pathogenesis. The inhibition of neuroinflammatory response and oxidative stress is now considered a potential strategy for depression prevention and/or therapy. Sodium butyrate (SB) is a sodium form of the endogenous butyrate. It can inhibit proinflammatory responses and oxidative stress in different models of disease. In the present study, we investigated the effect of SB on lipopolysaccharide (LPS)-induced depression-like behaviors, neuroinflammatory response, and oxido-nitrosative stress in the hippocampus and prefrontal cortex in C57BL6/J mice. Our results showed that 10 days of SB pretreatment at the dose of 300 but not 100 mg/kg markedly ameliorated LPS (0.83 mg/kg)-induced depression-like behaviors in the tail suspension test, forced swimming test, and sucrose preference test. Further analysis showed that 10 days of SB pretreatment not only prevented LPS-induced increases in proinflammatory cytokines, such as interleukin (IL)-1β, IL-6, and tumor necrosis factor-α, in the hippocampus and prefrontal cortex but also prevented LPS-induced enhancement of oxido-nitrosative stress. Taken together, these results demonstrate that SB is such an agent that could be used to prevent depression onset and/or progression, and inhibition of neuroinflammatory response and oxido-nitrosative stress may be a potential mechanism for its antidepressant actions.

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Section: Introductionmentioning

confidence: 94%

Lipopolysaccharide-Induced Depression-Like Behaviors Is Ameliorated by Sodium Butyrate via Inhibiting Neuroinflammation and Oxido-Nitrosative Stress

Qiu

Liu

et al. 2020

Pharmacology

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“…Пациенты после пересадки сердца используют разные виды защитных механизмов, и более активное применение защитных механизмов приводит к психологической подготовленности к трансплантации [4,5]. Уровни качества жизни (КЖ) в сфере физического благополучия у больных после ТС улучшаются, результаты лучше у физически активных пациентов [6].…”

Section: Discussionunclassified

Personality factors in heart transplant recipients

Simonenko

Федотов

Shirobokova

et al. 2020

RJTAO

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Objective: to assess the personal psychological profile of heart transplant recipients as the first stage in the development of post-transplant personalized rehabilitation programs. Materials and methods. From January 2010 to July 2019, 129 HTs were performed (mean age 46.6 ± 14.1 years; 74% (n = 95) were men, 26% (n = 34) were women). All patients in the heart transplant waiting list were examined by a clinical psychologist and a psychotherapist to exclude contraindications to transplant surgery. To assess personal traits, we used the standard multifactorial questionnaire by Cattell R., 16 PF (version A), which included 187 questions. Heart transplantation and absence of post-transplant severe cognitive impairments were the selection criteria for this study. Patients were surveyed before they were discharged from the hospital – 30–60 days following HT: during the period of complete recovery after surgery. In the present study, a retrospective assessment of the results was performed in 107 patients (n = 76 – men; n = 31 – women). Results. Analysis of the personality portrait revealed that over half of recipients were reserved, distant (factor A – schizothymia) and restrained (factor F – restraint; F2 – introvert; F4 – conforming) with lower mental capacity (factor B), and were shy, timid (factor H), with low super ego (factor G: irresponsible, tolerates disorder, flexible, open to change). Our results showed that 47% of patients (n = 18 out of 38 patients, n = 22 are pensioners) with a weak degree of factor C (reactive, affected by feelings) are workers to 42% (n = 29 out of 69, n = 28 – retirees) with a strong degree of the same factor. One year after HT, the number of physically active patients was higher among those with low anxiety compared with high anxiety (41% (18 of 44) and 32% (20 of 63), respectively, p = 0.41). Conclusion. Personality factors are non-modifiable characteristics of patients. They affect human behavior, return to work and to social life, as well as physical and psychological recovery from HT. Knowing the personal traits of recipients would allow to develop a personalized approach to their rehabilitation and a technique for timely examination after HT.

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“…While data from several groups, including our own, have suggested that elevated depressive symptoms occurring in the first year post‐transplant are associated with greater risk of long‐term rejection and mortality, this is the first study to demonstrate it is independent of objectively assessed PA. QoL is increasingly recognized as an important marker of “transplant success”, with some transplant recipients prioritizing QoL as comparably important to clinical outcomes . Surprisingly, psychological QoL indices do not necessarily improve after transplant and may actually worsen over time and may differ by transplant group . Although few studies have examined PA correlates of QoL following transplant, prospective studies among heart transplant recipients suggest that changes in functional capacity do not associate with QoL changes …”

Section: Discussionmentioning

confidence: 99%

Depressive symptoms, physical activity, and clinical events: The ADAPT prospective pilot study

Smith

Frankel

Bacon

et al. 2019

Clinical Transplantation

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Background: Physical inactivity and depressive symptoms following cardiothoracic transplantation are recognized as potentially modifiable psychosocial factors to improve clinical outcomes. However, few studies have prospectively assessed these in ambulatory, outpatient transplant recipients. Methods:We conducted a prospective, single-center study examining actigraphy-assessed physical activity (PA) levels over a 1-week period in heart or lung transplant recipients recruited at 6 months (range 4-9) post-transplant. Depressive symptoms (Centers for Epidemiologic Study of Depression [CESD]), quality of life (QoL), and clinical events (transplant-related hospitalization and death) were collected. Clustered Cox proportional hazards models were used to examine the associations between PA, psychological measures, and clinical events. Results: Among 105 potentially eligible participants, 66 (63%) met inclusion criteria and were enrolled between July, 2016 and May, 2017, including 42 lung and 24 heart transplant recipients. The mean age of the population was 53 years, 41% were women and 18% were black. Participants tended to be sedentary, with the majority of activity spent within the "sedentary" level (61%) and an average daily step count of 7188 (SD = 2595). In addition, participants tended to exhibit subclinical depressive symptoms, (mean CESD = 9.4 [SD = 8]) with only a subset exhibiting levels suggestive of clinical depression (22%). Over a median follow-up of 1.4 years (1.14, 1.62), 21 participants (32%) experienced at least one transplant-related hospitalization, including two deaths. In adjusted survival models, greater intensity of PA (HR = 0.45 [0.24, 0.84] per 0.2 METs, P = .012) was associated with a lower risk of clinical events, whereas greater depressive symptoms (HR = 2.11 [1.58, 2.82] per 9 CESD points, P < .001) at 6 months were associated a higher likelihood of subsequent transplantrelated hospitalization and/or death. Conclusions: Physical inactivity and depressive symptoms at 6 months post-transplant were predictive of subsequent adverse clinical events among ambulatory cardiothoracic transplant recipients. Future studies should examine whether improving these potentially modifiable post-transplant risk factors improves clinical outcomes.

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Quality of Life, Depression, Anxiety and Coping Strategies after Heart Transplantation

Cited by 24 publications

References 15 publications

Lipopolysaccharide-Induced Depression-Like Behaviors Is Ameliorated by Sodium Butyrate via Inhibiting Neuroinflammation and Oxido-Nitrosative Stress

Lipopolysaccharide-Induced Depression-Like Behaviors Is Ameliorated by Sodium Butyrate via Inhibiting Neuroinflammation and Oxido-Nitrosative Stress

Personality factors in heart transplant recipients

Depressive symptoms, physical activity, and clinical events: The ADAPT prospective pilot study

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