Quality of life, compliance, sleep and nasopharyngeal side effects during CPAP therapy with and without controlled heated humidification

Rühle, K. H.; Franke, KJ; Domanski, U; Nilius, Georg

doi:10.1007/s11325-010-0363-2

Cited by 46 publications

(46 citation statements)

References 15 publications

(17 reference statements)

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“…16 We also demonstrated, along with the improvement in adherence, an improvement in quality of life. In contrast, previous studies [7][8][9] did not achieve the same result. Ryan et al 7 conducted a study comparing the 4-week use of dry CPAP, CPAP with heated humidification, and CPAP with additional topical nasal steroid application in 125 subjects with the established diagnosis of OSA (AHI Ն10 events/h).…”

Section: Discussioncontrasting

confidence: 91%

“…AHI ϭ apnea-hypopnea index RDI ϭ respiratory disturbance index NREM1 ϭ non-rapid eye movement 1 NREM2 ϭ non-rapid eye movement 2 NREM3 ϭ non-rapid eye movement 3 REM ϭ rapid eye movement unchanged. 7 Another study by Ruhle et al, 8 which was a 4-week crossover study comparing the use of conventional CPAP with CPAP with heated humidification on 44 subjects with OSA, also only demonstrated the positive effect on dryness of the mouth. However, adherence and quality of life were not altered.…”

Section: Discussionmentioning

confidence: 99%

“…However, adherence and quality of life were not altered. 8 Routine use of heated humidification with CPAP was once again shown to have no effect on adherence according to the study conducted by Worsnop et al 9 This study was a randomized, parallel group design comparing 3 months of use of conventional CPAP and CPAP with heated humidification. The study demonstrated improvement in the symptoms of blocked nose, sneezing, dry nose, stuffy nose, dry mouth, and runny nose.…”

Section: Discussionmentioning

confidence: 99%

“…6 More recent studies did not show the positive effects of heated humidification on adherence when heated humidification was used routinely; however, nasal symptoms were significantly improved. [7][8][9] The discrepancy of the results warrants further studies.…”

Section: Introductionmentioning

confidence: 85%

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Effect of Heated Humidification on CPAP Therapy Adherence in Subjects With Obstructive Sleep Apnea With Nasopharyngeal Symptoms

et al. 2016

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BACKGROUND: The addition of heated humidification to CPAP has been shown to improve nasal adverse effects in subjects with obstructive sleep apnea (OSA). However, current data regarding improvement in CPAP adherence is conflicting. Furthermore, there are no data from a tropical climate area with a high humidity level. METHODS: In this prospective randomized crossover study conducted in Thailand, subjects with moderate to severe OSA with nasopharyngeal symptoms post-split-night study were enrolled in the study. Subjects were randomly assigned to receive CPAP with or without heated humidification for 4 weeks and then crossed over. Information on CPAP adherence, quality of life assessed by the Functional Outcomes of Sleep Questionnaire, nasopharyngeal symptoms assessed by a modified XERO questionnaire, and bedroom ambient humidity and temperature data were obtained. RESULTS: Data were collected on 20 subjects with OSA during the period of January to December 2014. Although the addition of heated humidification appeared to improve average hours of use for all days when compared with conventional CPAP, the difference was not statistically significant (CPAP with heated humidification ‫؍‬ 4.6 ؎ 1.7 h/night; conventional CPAP ‫؍‬ 4.0 ؎ 1.7 h/night, P ‫؍‬ .1). However, the addition of heated humidification improved CPAP adherence on the days of use (5.5 ؎ 1.5 h/night) compared with conventional CPAP (5.2 ؎ 1.4 h/night), P ‫؍‬ .033. Quality of life was also improved according to the Functional Outcomes of Sleep Questionnaire score (median 17.6 [interquartile range 3.5]) in the heated humidification group compared with conventional CPAP group (median 17.6 [interquartile range 4.5]), P ‫؍‬ .046. Significant reduction in the dry throat/sore throat symptom was noted only when CPAP with heated humidification was used. CONCLUSIONS: Even in a tropical climate area, CPAP adherence and quality of life appeared to improve when heated humidification was employed in subjects with moderate to severe OSA with nasopharyngeal symptoms post-split-night polysomnography. The improvement may be related to a reduction in the dry throat/sore throat symptom.

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Section: Discussioncontrasting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 85%

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Effect of Heated Humidification on CPAP Therapy Adherence in Subjects With Obstructive Sleep Apnea With Nasopharyngeal Symptoms

et al. 2016

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“…4 The palatal seal, by which the uvula closes the nasopharynx, is not always complete during CPAP, leading to leaks. 5 Mouth leaks during CPAP therapy seem to be particularly …”

mentioning

confidence: 99%

Effect of Heated Humidification on Adherence to Continuous Positive Airway Pressure Therapy in Subjects With Obstructive Sleep Apnea and Nasopharyngeal Symptoms

Karamanli¹

2016

Respir Care

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Numerous studies have demonstrated the efficacy of CPAP therapy for reducing symptoms (eg, daytime sleepiness), improving quality of life (QOL), reducing the risk of driving and occupational accidents, and preventing sequelae of obstructive sleep apnea (OSA), such as cardiovascular morbidity and mortality. [1][2][3] Many patients have trouble complying with CPAP therapy even though it is effective. 4 As many as 46 -73% of patients undergoing nasal CPAP therapy report considerable local persistent side effects, such as congestion, burning, sneezing, or dryness, 5,6 which can impair adherence to the therapy. 7 As a result, patients perceive that the therapy will cause problems and consequently refuse it. Therefore, interventions to treat these side effects could improve adherence and provide better QOL.Heated humidification was developed for patients undergoing CPAP who experience chronic nasal congestion. 4 The palatal seal, by which the uvula closes the nasopharynx, is not always complete during CPAP, leading to leaks. 5 Mouth leaks during CPAP therapy seem to be particularly

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Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

Kennedy

Lasserson

Woźniak

et al. 2019

Cochrane Database of Systematic Reviews

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Quality of life, compliance, sleep and nasopharyngeal side effects during CPAP therapy with and without controlled heated humidification

Abstract: By the using of the technology of cHH QOL and compliance did not improve. The side effects of CPAP therapy without humidification with respect to nasopharyngeal dryness, however, was reduced immediately as well as during the first weeks of treatment.

Cited by 46 publications

References 15 publications

Effect of Heated Humidification on CPAP Therapy Adherence in Subjects With Obstructive Sleep Apnea With Nasopharyngeal Symptoms

Effect of Heated Humidification on CPAP Therapy Adherence in Subjects With Obstructive Sleep Apnea With Nasopharyngeal Symptoms

Effect of Heated Humidification on Adherence to Continuous Positive Airway Pressure Therapy in Subjects With Obstructive Sleep Apnea and Nasopharyngeal Symptoms

Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea

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