Quality of life and the negative impact of comorbidities in long-term colorectal cancer survivors: a population-based comparison

Pate, Amy; Lowery, Jan T.; Kilbourn, Kristin; Blatchford, Patrick J.; McNulty, Monica; Risendal, Betsy

doi:10.1007/s11764-020-00876-w

Cited by 15 publications

(19 citation statements)

References 27 publications

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“…More than just the single variables of symptom burden, distress, and HRQOL, the interactions found between these variables are important. First, the results revealed a strong correlation between LRTI symptoms and HRQOL, confirming previous research on symptom burden as a risk factor for impaired HRQOL [ 6 , 11 , 24 – 26 ]. It is worrisome that these patients often are underdiagnosed and undertreated, although the symptom burden severely impairs HRQOL [ 2 , 7 ].…”

Section: Discussionsupporting

confidence: 86%

“…Compared to norms, the participants reported a large impairment in overall HRQOL and in all the functional subdimensions, except for emotional function, as well as a high symptom burden for fatigue, insomnia, and pain. Corresponding studies on the long-term HRQOL of survivors with pelvic malignancies report slightly better overall HRQOL [ 9 , 25 ], mainly explained by complete disease remission and the decline of symptoms over time [ 11 , 24 ]. Here, an obvious explanation may be that our participants represent a selected sample with established LRTIs where the symptoms had not declined over time.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, HRQOL may give a holistic picture of the cancer survivors' perceived health and overall well-being. Previous studies indicate that pelvic LRTIs across cancer types may severely impair the survivors' HRQOL, where higher treatment toxicity and comorbidity after radiation as well as combinations of chemotherapy and radiotherapy seem to be important risk factors [24][25][26]. Nevertheless, there is a lack of studies focusing on the influence of pelvic LRTI symptoms on HRQOL.…”

Section: Introductionmentioning

confidence: 99%

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Symptom burden, psychological distress, and health-related quality of life in cancer survivors with pelvic late radiation tissue injuries

Velure

Müller

Hauken

2021

Support Care Cancer

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Purpose Curative radiotherapy for cancer may lead to severe late radiation tissue injuries (LRTIs). However, limited knowledge exists about pelvic cancer survivors’ LRTI symptoms, distress, and health-related quality of life (HRQOL). We sought to assess the symptom burden, distress, and HRQOL in survivors with established pelvic LRTIs compared to norm populations and to investigate the relation between these factors. Methods Cancer survivors referred for treatment of established pelvic LRTIs were recruited nationwide. LTRIs were assessed with the Expanded Prostate Cancer Index Composite (EPIC), psychological distress was assessed with the General Health Questionnaire (GHQ-12), and HRQOL was assessed with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORCT-QLQ-C30). Results A total of 107 participants (mean age 64, 53% men) were included. Compared to norms, participants reported more urinary (mean 68.7 vs. 89.5; p = 0.00; d = 1.4) and bowel symptoms (mean 62.5 vs. 92.4; p = 0.00; d = 2.7), increased psychological distress (mean 13.4 vs. 10.3; p = 0.00; d = 0.6), and overall poorer HRQOL (mean 54.9 vs. 71.2; p = 0.00; d = 0.7). Higher symptom burden and higher levels of psychological distress were associated with lower HRQOL (r2 = 46%), but psychological distress did not moderate the influence of symptoms on HRQOL. Conclusion Cancer survivors with established pelvic LRTIs are highly burdened compared to norms. The association of the LRTI-related symptom burden with HRQOL is independent of the level of psychological distress. Both coping and treatment interventions are crucial to promoting long-term health and HRQOL. Trial registration NCT03570229.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Symptom burden, psychological distress, and health-related quality of life in cancer survivors with pelvic late radiation tissue injuries

Velure

Müller

Hauken

2021

Support Care Cancer

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“…High prevalence of comorbidities had a significant adverse effect on general QoL regardless of the patients' condition. High comorbidity scores were associated with low QoL both among the participants and the controls [12].…”

Section: Qol Questionnairementioning

confidence: 89%

Indicators of the quality of life of patients with colorectal cancer: A literary review

Zhabagin¹,

Zhabagina

Rakhmankulova

2021

Onkol. radiol. Kaz.

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Relevance: GLOBOCAN estimates 1.9 million new cases of colorectal cancer (CRC) and 935,000 deaths from CRC in 2020. CRC accounts for every tenth cancer case or dying from cancer. According to the Oncological Service of the Republic of Kazakhstan (RK), in 2019, CRC ranked 5th in incidence and mortality among all cancers. With a survival time of more than five years, one of the main criteria that determine the condition of patients and the effectiveness of treatment is their quality of life (QOL). Understanding QOL parameters is essential to assess the full impact of the disease on an individual, family, and community. The purpose of the study was to analyze the quality-of-life indicators in patients with colorectal cancer and validate a Kazakh variant of the EORTC QLQ-CR-2 questionnaire in RK. Results: The QOL of patients with CRC globally is relatively low in its physical, mental, social, and clinical aspects. The most important factors affecting the QOL are sexual dysfunction, body dissatisfaction in ostomy patients, chronic recurrent diarrhea, symptoms of distress, and high fatigue. The patient’s lifestyle, age, gender, stage of the disease, and psycho-emotional status all affect the QOL of patients with CRC. It should also be noted that CRC survivors who have been physically active report a better QOL than those who were not physically active. Conclusion: The fact that no study has been conducted in the RK for the QOL of patients with CRC necessitates a survey to understand the QOL parameters in patients with CRC using the Kazakh version of the EORTC QLQ-CR-2 questionnaire. We plan to conduct such a study in the near future within the framework of grant funding for young scientists IRN AP09058432 KN MES RK and publish the results.

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“…Қосу критерийлері: үлкен популяцияларда жүргізілген рандомизацияланған және когорттық зерттеулер туралы есептер; мета-анализдер мен жүйелік шолулар; мақалалар ағылшын және орыс тілдерінде. Шығару критерийлері: 2011 жылдан бұрын жарияланған мақалалар; дәлелсіз материалдар, тезистер, рефераттар және газеттегі ма- [12].…”

Section: берілген зерттеудің мақсатыunclassified

Indicators of the quality of life of patients with colorectal cancer: A literary review

Zhabagin¹,

Zhabagina

Rakhmankulova

2021

Onkol. radiol. Kaz.

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Relevance: GLOBOCAN estimates 1.9 million new cases of colorectal cancer (CRC) and 935,000 deaths from CRC in 2020. CRC accounts for every tenth cancer case or death from cancer. According to the Oncological Service of the Republic of Kazakhstan (RK), in 2019, CRC ranked 5th in incidence and mortality among all cancers. With a survival time of more than five years, one of the main criteria that determine the condition of patients and the effectiveness of treatment is their quality of life (QOL). Understanding QOL parameters is essential to assess the full impact of the disease on an individual, family, and community. The purpose of the study was to analyze the quality-of-life indicators in patients with colorectal cancer and validate a Kazakh variant of the EORTC QLQ-CR-2 questionnaire in RK. Results: The QOL of patients with CRC globally is relatively low in its physical, mental, social, and clinical aspects. The most important factors affecting the QOL are sexual dysfunction, body dissatisfaction in ostomy patients, chronic recurrent diarrhea, symptoms of distress, and high fatigue. The patient’s lifestyle, age, gender, stage of the disease, and psycho-emotional status all affect the QOL of patients with CRC. It should also be noted that CRC survivors who have been physically active report a better QOL than those who were not physically active. Conclusion: The fact that no study has been conducted in the RK for the QOL of patients with CRC necessitates a study to understand the QOL parameters in patients with CRC using the Kazakh version of the EORTC QLQ-CR-2 questionnaire. We plan to conduct such a study in the near future within the framework of grant funding for young scientists IRN AP09058432 KN MES RK and publish the results

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Quality of life and the negative impact of comorbidities in long-term colorectal cancer survivors: a population-based comparison

Cited by 15 publications

References 27 publications

Symptom burden, psychological distress, and health-related quality of life in cancer survivors with pelvic late radiation tissue injuries

Symptom burden, psychological distress, and health-related quality of life in cancer survivors with pelvic late radiation tissue injuries

Indicators of the quality of life of patients with colorectal cancer: A literary review

Indicators of the quality of life of patients with colorectal cancer: A literary review

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