Quality of life and rehabilitation in social and professional life after autologous stem cell transplantation

Being in work or the equivalent is an important goal after allo-SCT and is used as an indicator of recovery. The aim was to elucidate occupational status and factors associated with work among SCT survivors. Adults in working age with a haematological disease (n = 177) were followed up within a median of 8 (range 28) years post allo-SCT. Predictors of not being in work at all or working part-time because of sick leave, disability pension or early old-age pension were analyzed using logistic regression analyses. At diagnosis, 82% of the participants were working full-time and 2% were on sick leave or old-age pension. At follow-up, 52% were working full-time, 27% were working part-time and 17% were on sick leave, disability pension or old-age pension. Not working at all was associated with multi-morbidity (P = 0.01) and poorer health (P = 0.00). Working part-time was associated with a higher age at diagnosis (P = 0.00), being a woman (P = 0.03), being born abroad (P = 0.03) and multi-morbidity (P = 0.00). In conclusion, the majority of survivors were in paid work at follow-up; however, a substantial number were not working or worked part-time.

“…Reduced physical work capacity due to SCT Yes (some-much) 76 (43) 59 (41) In part-time work combined with sick leave or disability pension.…”

Section: P-valuementioning

confidence: 99%

Section: P-valuementioning

confidence: 99%

Occupational status among adult survivors following allo-SCT

Winterling

Johansson

Wennman-Larsen

et al. 2014

“…37 So far, the EORTC QLQ-C30 questionnaire has only been used in a few studies with HSCT patients, and in almost all of these cases the subjects were not inpatients. [38][39][40] As this questionnaire is internationally standardized and has shown a high reliability and validity in many studies with cancer patients it was also used for this study. 40 Statistics All 64 randomized patients represented the 'intent-to-treat' population.…”

Section: Quality Of Lifementioning

confidence: 99%

“…[38][39][40] As this questionnaire is internationally standardized and has shown a high reliability and validity in many studies with cancer patients it was also used for this study. 40 Statistics All 64 randomized patients represented the 'intent-to-treat' population. At the time of discharge, data for analysing the physical parameters endurance, strength and lung fuction were available for 24 surviving patients of the TG, and 25 surviving patients of the CG.…”

Section: Quality Of Lifementioning

confidence: 99%

A controlled randomized study examining the effects of exercise therapy on patients undergoing haematopoietic stem cell transplantation

Baumann

Kraut

Schüle

et al. 2009

155

188

A haematopoietic SCT (HSCT) can cause severe side effects, which may have a profound impact on a patient's life both physically and psychologically. Some studies have shown that physical activity has positive effects for inpatients after an HSCT. Therefore, the question arises whether a controlled exercise programme right from the beginning of the conditioning phase could help contribute to a patient's physical and psychological recovery. To evaluate the different effects of specific, moderate physical activities on the physical and psychological condition of HSCT patients we performed a controlled randomized study with 64 inpatients undergoing an allogeneic or autologous HSCT. The patients were randomly assigned to two groups. Although the training group took part in a specific programme of exercise therapy twice a day throughout the entire hospitalization phase, patients in the control group were offered the hospital's standard mobilization programme. The results of this study showed significant differences in favour of the training group regarding strength, endurance, lung function and quality of life. However, further studies are needed to confirm these results.

“…1 The treatment is accompanied by complications and side effects that adversely affect nutritional status, 2,3 body composition, 3,4 quality of life (QoL) and functioning capacity (that is, work) 5 for prolonged periods of time.…”

Section: Introductionmentioning

confidence: 99%

Telephone-delivered nutrition and exercise counselling after auto-SCT: a pilot, randomised controlled trial

Hung

Bauer

Horsely

et al. 2014

Adverse changes in nutrition-related outcomes including quality of life (QoL) occur after PBSC transplantation. This randomised controlled trial aims to evaluate the impact of nutrition and exercise counselling provided at hospital discharge on nutritional status, body composition and QoL post transplantation. Usual care (UC) (n = 19) received no intervention after discharge; extended care (EC) (n = 18) received fortnightly telephone counselling from a dietitian and exercise physiologist up to 100 days post transplantation. Nutritional status (patient-generated subjective global assessment, and diet history), QoL (EORTC QLQ-C30 version 3) and body composition (air displacement plethysmography) were assessed at pre-admission, discharge and 100 days post transplantation. Intervention groups were compared using two-sample t-tests of changes in the outcomes; results were adjusted using analysis of covariance. EC exhibited clinically important but not statistically significant increases in protein intake (14.7 g; confidence interval (CI) 95% − 6.5, 35.9, P = 0.165), cognitive functioning (7.2; CI 95% − 7.9, 22.2, P = 0.337) and social functioning (16.5; CI 95% − 7.3, 40.3, P = 0.165) compared with UC. Relative to pre-admission, EC experienced less weight loss than UC (−3.3 kg; CI 95% − 6.7, 0.2, P = 0.062). Physical activity was not significantly different between the groups. Ongoing nutrition and exercise counselling may prevent further weight loss and improve dietary intake and certain QoL components in autologous PBSC transplantation patients following hospitalisation.