Quality of life and psychological status in patients with primary Sjögren's syndrome and sicca symptoms without autoimmune features

Abstract

Objective. To compare pain, fatigue, and sicca symptoms; quality of life; and psychological status between patients with primary Sjö gren's syndrome (SS) and those with sicca symptoms but no autoimmune features (sicca asthenia polyalgia syndrome [SAPS]), and to determine whether a psychological pattern can be detected in patients with SAPS, which could suggest psychological distress as the cause. Methods. This cross-sectional, prospective study included 111 patients with primary SS according to the AmericanEuropean Consensus Group criteria and 65 SAPS patients with no focus on lip biopsy and no anti-SSA/SSB antibodies. Pain, fatigue, and sicca symptoms were assessed using visual analog scales; quality of life was assessed using the Short

Sicca symptoms and their impact on quality of life among very long-term survivors after hematopoietic SCT

“…Reduced QoL measured with the SF-36 was found in a cohort of patients suffering from Sjö gren's syndrome, a disease with comparable symptoms with cGVHD. 44 In conclusion, within the limitations of the number of subjects studied, sicca symptoms and/or reduced saliva and lacrimal fluid flow were common long-term complications after HSCT. They were not necessarily a consequence of GVHD.…”

Discrimination between Sjögren's and Non-Sjögren's Sicca Syndrome by Sialoscintigraphy and Antibodies against α-Fodrin and Ro/La Autoantigens

“…Non-Sjögren's syndrome occurs when the lacrimal or salivary glands are damaged but, unlike SS, NSS is not caused by an autoimmune disorder. 15 The most serious aspect of SS is the increased risk for developing malignant neoplasms. 16,17 Establishing the criteria for SS and NSS discrimination is, therefore, extremely important.…”

Stress Factors and Mental Disorders in Sjogren's Disease: Modern Trends in Research

“…[56] отмечено, что в случаях БШ с распространенным болевым синдромом, который служит основным проявлением фибромиалгии, значительно выше частота депрессии. Следует отметить, что усталость и боль, имеющие тесную связь с депрессивными и тревожными расстройствами, в большей мере дезадаптируют больных, чем такой характерный для БШ признак, как сухость сли-зистых оболочек [57].…”

“…В качестве характерных особенностей больных выделяют демонстративность (30%), шизоид-ность, параноидность (38-71%) и психастению (70%), склонность к дисфорическим реакциям [5,8,19,58,59]. Другие авторы среди личностных особенностей указывают на повышенные показатели психотизма, нейротизма и та-ких ананкастных черт, как перфекционизм, озабоченность деталями и правилами [57]. Кроме провоцирующих и предрасполагающих фак-торов, необходимо отметить возможное влияние терапии БШ на развитие психических расстройств.…”