Quality of life and depression in haemodialysis patients

Abstract

Chronic kidney disease is associated with a high prevalence of depression, which increases inversely with the glomerular filtration rate. This paper aims to evaluate the factors associated with a low quality of life and depression in patients on haemodialysis. Two hundred patients undergoing haemodialysis answered the Medical Outcomes Study 36 - Item Short - Form Health Survey (SF-36) and Beck Depression Inventory (BDI). Clinical and laboratory variables were analysed and correlated with these two tools. The prevalence of depression was 29%. Anaemia and hypoalbuminemia were independent risk factors for depression. All SF-36 domains showed worse results in patients with depression, and the pain domain presented the highest correlation. Our findings provide evidence that patients on haemodialysis have a low quality of life and a high prevalence of depression. A greater number of comorbidities, an excessive number of medications, diabetes mellitus, anaemia and hypoalbuminemia were associated with a reduced quality of life.

Kronik Böbrek Yetmezliği Hastalarının Glomerüler Filtrasyon Değerinin Bağımsız Değişkenler İle Yordama Gücü

“…Yapılan çalışmalar, diyaliz hastalarında depresyonun hastaneye yatışta artış ve mortalite ile ilişkili olduğunu göstermektedir. 3,7,8 KBY hastalarında uyku sorunları prevalansının; %50-80 oranında olduğu bildirilmektedir. 2,9,10 Diyaliz tedavisi ile ilişkili ağrı, yorgunluk, üremik sendrom ve anksiyete uyku problemi yaşamalarının başlıca sorumlusu olarak gösterilmektedir.…”

Behavioral Changes During Development of Chronic Kidney Disease in Rats

“…Therefore, the translational value and relevance of surgically induced CKD might be disputable in medicine. Furthermore, it should be considered that several behavioral and mental disorders in CKD patients may arise from primary disease (55)(56)(57)(58) or from comorbidities (11), as well as from psychosocial aspects of chronic illness (8,19,59).…”

“…It has been shown that CKD leads to cardiovascular disease (4), stroke (5) and decreased locomotor activity (6). Individual's quality of life can be further decreased by sexual dysfunction (7), neurological and mental disorders including anxiety and depression (7)(8)(9)(10)(11), as well as cognitive impairment (12)(13)(14)(15)(16)(17) or epileptic seizures (18), all of which lead to increased socio-economic burden of affected people (19). Although, the exact pathophysiological mechanisms underlying the neurological complications of CKD remain unclear, there are several factors that might play a role, e.g., uremic encephalopathy (20), oxidative stress (21)(22)(23) and inflammation (21,22).…”

Calidad de vida en adultos jóvenes trasplantados renales con y sin depresión

“…Teles, et al incluyeron a pacientes con edad media de 46.6 ± 15.4 años y en tratamiento de hemodiálisis, observando una prevalencia de depresión del 29% y menores puntuaciones en todos los dominios SF-36 en los pacientes con depresión. Además, identificaron factores asociados con el deterioro de la calidad de vida como el número de comorbilidades, la presencia de diabetes, anemia e hipoalbuminemia 21 .…”